LOCUS       pTC-F14                14155 bp    DNA     linear       07-DEC-2023
DEFINITION  Acidithiobacillus caldus strain plasmid TC-F14 isolate plasmid
            TC-F14.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Acidithiobacillus caldus
  ORGANISM  Acidithiobacillus caldus
            Unclassified.
REFERENCE   1  (bases 1 to 14155)
  AUTHORS   Zhou,D.
  TITLE     Compelete sequence of c715304
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14155)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2023) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
FEATURES             Location/Qualifiers
     source          1..14155
                     /organism="Acidithiobacillus caldus"
                     /mol_type="genomic DNA"
                     /strain="plasmid TC-F14"
                     /isolate="plasmid TC-F14"
                     /isolation_source="Unknow"
                     /host="Unknow"
                     /country="China"
     CDS             1..876
                     /gene="repA"
                     /codon_start=1
                     /transl_table=11
                     /product="Replication protein RepA"
                     /translation="MALDIMAAFTNEPPELDFIWPGFLAGTVGALVAPGATGKSFWAL
                     EAAMAVACREPGGDLLGLAPKYTGRVVYLAGEDPEPALIRRVHAIGQHLNQSAREAIA
                     ENLTLEPIMGKRLNIMDEAHLHRIIEASSGARLIVLDTLSRIHNLDENSNGAMAHLVA
                     TLEHIAASTGASVLYLHHVSKGSAMAGQTDQQQAARGASALIDNARWCGYVAKMAEHE
                     AARLSDRSFDRAPIGDRRGFFVRFGVSKQNYDATSLESWYQRVDGGVLMPVDLVEATS
                     NGKVKNDGKGKRDEI"
     CDS             940..1851
                     /gene="repC"
                     /codon_start=1
                     /transl_table=11
                     /product="Replication protein RepC"
                     /translation="MKKGSAMTFDLTHARHDPAHCLAPGLFRSLKRGERKKLKLDVTY
                     TYGKDRVEFSGPEPLGVDDMRVLQGLVAVAATCGSESRGIMLRPEPKSEAGHQLRLLL
                     DLEWDAKEKDAMVAKGSFRQLASELGYATDSGGAFRVIRESIERLWKVSVIVQREGKR
                     QGFRILSEYASDEDTGKLFVALNPRLAEAIIGARPHTRIEMAEVRALQTDPARLIHQR
                     LCGWIDPGKSGRVELDTLCGYIWPDQASGSTMRMRRQTARNALPELTTVGWTVNEYAK
                     GKWEISRPKALALTLTSPCPNVDEPLP"
     repeat_region   1793..1902
                     /gene="iterons"
     CDS             2270..2644
                     /codon_start=1
                     /transl_table=11
                     /product="Hypothetical protein"
                     /translation="MEAGPITQQDVAAAADQLGGPANTNAAKIREILGRGSLATIQRH
                     LQALRDAQRAPELPEAVQTIPTPPEAVSEASRGIWAAAWAMAEQRHAESLAHAPCWVI
                     TGITFAYSGNGCQSLSPNTTLL"
     CDS             2659..3228
                     /codon_start=1
                     /transl_table=11
                     /product="Invertase/recombinase-like protein"
                     /translation="-
                     *TIPATLTLQLAIEDGFTDLEAGGGLADAEALGDQLLGALLLLWGHDGFASPFAATGD
                     CSGEACQGALPDNVTLELSERPKEMEGQSPGWGGGVNGFGQGPKTAPALFQVVQDLDE
                     VGERTGQAIQSPDGEHVARAEEGHGLHQSGAFRLGPAGDILKGVFAPGMVQGIPL*VE
                     VLVSGGYPRITDLCH"
     CDS             3512..3973
                     /codon_start=1
                     /transl_table=11
                     /product="Hypothetical protein"
                     /translation="-
                     SVQIRPITAGGGTEGNG*AVPGVDGHDGQGQIHQFLLLEITADVFIERIRDAFIDAGD
                     SIGPRQRRAFPLAEKWRFPPSGEGIKTLLHLAPGAGFLAVHVDAKGAAVEDGCAQLHQ
                     FQQRWFQVASMEISLQIPQAADAVGGYQAIVDAFFHH"
     CDS             4691..5551
                     /codon_start=1
                     /transl_table=11
                     /product="Hypothetical protein"
                     /translation="-
                     SCFVKGL*T*LLIS*WCQFRFFYKLCNFNLMFFYFICQYIFKHIVQHIKT*LFNPRIE
                     RYRNEF*KYLIFSKKHFYLIHTIIFYTIYVIFAVWKCSLSIFLKIQ*ACI*EQRFYFF
                     YCVFYILSEFIVYHIFKKIFLLF*PFLTVKNIIFDNPYPLEKSF*QLAVMCLDDI*NF
                     LFVLVIVYGVFFSQFCNRKRHRCDYTLYLFLLKISI*IIIFILYINIAIVSYVILVIT
                     VFKKEL*IAIL*LLKGYYYIVR*ACRAFLGVIILRQVFL*CWSNTCCLFFPEKH"
     repeat_region   6087..6112
                     /gene="IRR_ISAtc1"
     CDS             6101..7315
                     /gene="ins"
                     /codon_start=1
                     /transl_table=11
                     /product="ISAtc1 transposase"
                     /translation="-
                     CG*PQIQLAQDEVSHGDEVLVGAVATGFRLGGLEEAVEALQDAIADLALEPAEDPVPM
                     VHEGVGDPDDRRQIAGSGVFQPGFQEGSPLVAILDREDVLKGQAELVGLRRLEVLVFE
                     QFLQLFFLLHFEVAIVLEPKPAGLFEIWLGEDFPLAHVVYGLVDELHEVKTIESDLRI
                     GQVLGSPFLEGRREVHAHIGDRFRATTMGLKISGEFLKGLGILAGSSEQESPGIQIHE
                     ERDVVMSMPTAGFIDADGMDIGHIHRSTSFGHIMVNHSPQELVGLTDHASCRQYRHLP
                     HQGHDQRFKEQGETRAFPRPGNRYLMHSMLLALHTRYTGMEIGFMLEEIHVPPGMVTG
                     IMYRTLLTTDGASKATTFGKVDVQIQAFLLHRESHMIHQPRRNQS*RERKQLFRDH"
     repeat_region   7363..7388
                     /gene="IRL_ISAtc1"
     CDS             7765..8025
                     /codon_start=1
                     /transl_table=11
                     /product="Hypothetical protein"
                     /translation="-
                     EQKMFWTKASGQGKKSEMCV*SKQVL*GSGSGKFSIQIVQG*RRYAQH*G*NQESTFS
                     Y**VLQEAATIFPVPEGAPECRRRRYSH"
     CDS             8418..9080
                     /gene="mobE"
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein MobE"
                     /translation="-
                     RSHLWGGAGRGVCLQGRSPRSVAKFLRDLSAQFVH*CCFVSACSMAPISRRP*YTVFP
                     SCFSYPKLFATLAATSMGTQGPDWMPSNAGHSWTIPPMRVWMAASSALRRCSFCSTCR
                     TSFECHQISTSPAAYDPIPTTTSTSPAQTDLDQSVFPKSLRKASTSCCPALDSSSDDA
                     AEILPLAASSALLAILFAVFSMALGSLLNVP**ASKVTRMGNMASF"
     CDS             9177..9857
                     /gene="mobD"
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein MobD"
                     /translation="-
                     LISRLQCGLCGLSIAAQCGAFRDGELGIGAAQRKPVVHEFVGHQIV*LWKYHGSGNTV
                     FQSAVGKPGKFFRCPEIRVQHGIGGMVGLGRFQKIFQQLQRVPLPVDGPEHDEFPVLL
                     LCHIVQDAAILDECRSGPRCGIDHDAVFGVVLDDVTEMDISLFGIQVADMARQQVFEG
                     LVGIGIAVVTLHQNTGMTPGEQCIDESHCHGGFSDAPLATTDDQYLVERLAH"
     CDS             9854..10249
                     /gene="mobC"
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein MobC"
                     /translation="-
                     *VLRIRFDRKGSSLRDRCCVRLAGRCWRRCGGFFLSGDC*FVLLLSCNDLSDGFR*YT
                     EHVIMLQGIRNLFAGVAFLDQGFQVTLDRSDDIGFPAFAGDFSGLLGFLQIFQCSPCF
                     FRVCVYIVELFRACH"
     misc_recomb     10250..10530
                     /gene="oriT"
     CDS             10534..10845
                     /gene="mobB"
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein MobB"
                     /translation="MPFTVQGLEPLDAVVNVRLTASEKARLREDADLAGLSVSELVRR
                     RYFGRPIVAHADAVLLKELRRIGGLLKHVHNESGGAYSQQTAAVLVTLKAAIEGLSHD
                     R"
     CDS             10835..13504
                     /gene="mobA"
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein MobA"
                     /translation="MIVKKVKSNRTKGKAASIRDLTNYIREPQNRNPNEKVLYANGRG
                     FISDTHAAQREEMVALAAEAVRSRNPVNHYILSWREGEQPSPEQVEEAVSIFLDELGL
                     QEHQVIYALHKDTDNLHLHIAVNRVHPETLKCVEINKGFDLESAHRAIARIEHAQGWQ
                     REQNGRYEVLENGELGREHLEPNKRRQPEQRKRDKENRTGEKSAERIAIEIGAPIIKQ
                     AQSWEQLHRELAAQGMRYEQKGSGALLWVGEVAVKASSADREASLGKLQKRLGAYEPA
                     QAPSPVAQRKPEPLQPDRPEWEDFMAGRKMHYAEKNAAKLSMDQRQEQERKALQARQQ
                     EQRKVLLGGRWNGKGEALNALRGVLAAEQAAEKAALKERHQQERQQWRQQYRPYPDFE
                     QWLRREHGAEQATRWRYREAEPQRIEGDSTEAPKPRDIRAYRAEIVGQEVRYTPKSGA
                     GGGPGGVSFVDKGRIIEIHDWRNQDTTLAALQLSAQKWGKFTVTGNDEYKALCVKLAV
                     EHGFQITNPELQEVIRQERQRMRQERAQAMKSEQIKPFERYAEAVGAERYRVTSIKMR
                     PDGSKQTFILDKRDGITRGFTPEEIAQRTPEMQRLQRRGENLYYTPLSEGKHHILIDD
                     MDREKLDRLIRDGYQPAVVLESSPGNYQAVITIPKLGTPFDKDVGNRLSDALNREYGD
                     PKLSGAIHPHRAPGYENRKPKHRREDGSYPEVRLLKAERRECGKTLALSREIDAGYQR
                     QAAEKALKTPVEQFSEPNSTQTTPVSEKTATEAYWRHYRDVRKRQRGMLDLSRVDAMI
                     AVRMRVTGFDQSAIEGAIYQCAPSIREQQESRDWTDYARRTARYAYSAAGDRQAADLG
                     KYRQQWEKLEGRERQQEQAKAREIERNGPSMSR"
     CDS             12446..13504
                     /gene="repB"
                     /codon_start=1
                     /transl_table=11
                     /product="Replication protein B"
                     /translation="MKSEQIKPFERYAEAVGAERYRVTSIKMRPDGSKQTFILDKRDG
                     ITRGFTPEEIAQRTPEMQRLQRRGENLYYTPLSEGKHHILIDDMDREKLDRLIRDGYQ
                     PAVVLESSPGNYQAVITIPKLGTPFDKDVGNRLSDALNREYGDPKLSGAIHPHRAPGY
                     ENRKPKHRREDGSYPEVRLLKAERRECGKTLALSREIDAGYQRQAAEKALKTPVEQFS
                     EPNSTQTTPVSEKTATEAYWRHYRDVRKRQRGMLDLSRVDAMIAVRMRVTGFDQSAIE
                     GAIYQCAPSIREQQESRDWTDYARRTARYAYSAAGDRQAADLGKYRQQWEKLEGRERQ
                     QEQAKAREIERNGPSMSR"
     CDS             13559..13801
                     /gene="pasA"
                     /codon_start=1
                     /transl_table=11
                     /product="Antitoxin protein PasA"
                     /translation="MLAIRLPTEVENRLEALAQATGRTKTFYAREAILEHLDDLEDLY
                     LAEQRLIDIRAGRSRTYTLEEVERDLGLAD*V**QGQ"
     CDS             13767..14039
                     /gene="pasB"
                     /codon_start=1
                     /transl_table=11
                     /product="Toxin protein PasB"
                     /translation="MAWRIEFDDKAKKDLAALDKSVAKRITAFLRERVAHLDDPRSIG
                     EALKGSKLGDFWKYRVGDWRIIASIEDEALRILVVRIGNRREVYRK"
ORIGIN      
        1 atggctttgg acattatggc ggcattcacc aacgaaccgc cagaactgga tttcatctgg
       61 ccgggattcc tggccgggac cgtgggcgca ctggttgcac ctggcgcgac cggcaagagc
      121 ttctgggcct tggaagcggc gatggccgtc gcgtgccggg agcctggcgg agacctgctg
      181 gggcttgcgc cgaagtacac cgggcgcgtt gtctatctgg ccggagaaga tccagaacca
      241 gccttaatcc ggcgcgttca tgccataggc cagcatctca accagtcggc ccgcgaagcc
      301 attgctgaga atctgaccct tgagccgatc atgggcaagc ggctgaacat catggacgag
      361 gcccacctgc atcgcatcat cgaggccagc tccggggcac ggctgatcgt gctggacacc
      421 ctgagccgta ttcacaatct ggacgagaac agcaacggtg ccatggcgca tctggtggca
      481 accctggagc atattgccgc cagtaccggc gcatcggtgc tgtacctgca tcatgtcagc
      541 aaaggcagcg ccatggccgg gcagacggat cagcagcaag cggcgcgggg ggcatcagcc
      601 ctgatcgaca atgcccgttg gtgcggctac gttgccaaaa tggcagagca tgaggccgcg
      661 cgactgagcg accgtagctt tgaccgtgcg cccattggcg accggcgcgg cttcttcgtg
      721 cgcttcggtg tgagcaaaca gaactacgac gcaacatcgc tcgaaagctg gtatcagcga
      781 gtggatggcg gggtgttgat gcccgtcgac ctggtggaag caacgagcaa tgggaaggta
      841 aaaaacgatg gcaaaggaaa gcgcgatgag atctgaccct gtgctatcgc accccctgcc
      901 gatccccttt ttgtgtggct atacccaggg aggcaagcca tgaagaaggg aagcgcgatg
      961 accttcgacc tcacccacgc aagacacgat ccggctcact gtctggctcc tggtcttttt
     1021 cgcagcctca agcgtggcga gcgaaaaaaa ctcaagttgg acgtgaccta cacttacggt
     1081 aaggatcgtg ttgagtttag cggtccagag ccgcttggtg ttgatgatat gcgtgtcctg
     1141 caaggtctcg ttgccgtcgc cgccacctgt gggtcggaaa gtcggggaat catgctgcgc
     1201 cctgagccaa aaagtgaagc gggacatcag ttgaggctgt tgcttgattt agaatgggac
     1261 gccaaggaaa aagatgccat ggtcgctaaa ggcagcttcc ggcaacttgc aagcgagctt
     1321 ggatatgcta cagacagtgg cggcgcgttt cgtgtcattc gagaaagtat cgaacgacta
     1381 tggaaggtct ccgtgatcgt tcagcgcgag gggaaacgac agggattccg catcctctcc
     1441 gaatatgcca gcgacgaaga caccgggaag ctatttgttg ccttgaaccc cagactggct
     1501 gaggcaatca tcggagcacg tccacacacc cgtatcgaga tggcagaggt gcgagcactg
     1561 cagactgacc ctgcccgtct cattcatcag cggctatgcg gttggatcga ccccggcaag
     1621 tccgggcgcg tcgagctgga cacgctttgc ggttatatct ggcccgatca ggccagcggg
     1681 tcaaccatgc gtatgcgccg acagactgct cgtaatgcgc tgcccgagct taccactgta
     1741 ggctggacgg tgaacgaata cgccaaggga aaatgggaaa tcagcagacc gaaggccctt
     1801 gccctaacgt tgacgagccc ctgccctaac gttgacgagc ccctgcccta acgttgacga
     1861 gcccctgccc taacgttgac gagcccctgc cctaacgttg acaccacaaa acacgctaag
     1921 ccagcattga cggggctttg cggaagattt gaaaaatcga tccaagatat tctccaagaa
     1981 tatccactat gcgcggcctt cagccgccgc ttgatgcgtc gtcagaagcc ttgcacttcg
     2041 gccttcggcc tgcgcgggct acgcccttgc agacacaccc cgccgcccgc ccgcccgccg
     2101 cccgcttgta cgttctccaa ggtggataac gtgacttacg ttatccacca accatgccgc
     2161 cgatagtgag cacctactgg gtagacgagc ggctgatggt gtaaataacc ttgacaaata
     2221 gatgtaaatt tactatatta catttacaat gtaattacag gagagtgcca tggaagcagg
     2281 accgatcaca caacaagacg ttgccgccgc cgctgaccag cttggcggcc ccgccaacac
     2341 caatgccgcg aaaatccggg agattctggg ccgggggagt ctcgccacca ttcaacgcca
     2401 tttgcaggcc cttagagacg ctcagagggc tccagagcta ccagaggccg tccagacgat
     2461 tccaacgcct cctgaggccg tttctgaggc ttccagaggc atttgggcgg cggcctgggc
     2521 aatggcggag caacgccacg cggaaagtct ggcgcatgcc ccctgctggg ttataacagg
     2581 tattactttt gcgtactctg gcaacggatg ccagtctcta tctcccaata caaccctgct
     2641 ttagggcgaa aatccatgct atgaaccatt cccgccacgc ttacgctgca actcgcgata
     2701 gaggacggtt ttactgatct tgaggcgggt ggcggcctcg cggacgctga ggccctgggc
     2761 gatcaactgc tgggcgcgtt gctgcttctc tggggtcatg acgggtttgc gtcccccttt
     2821 gcggccacgg gcgactgcag cggcgaggcc tgccaaggtg cgctcccgga taatgtcacg
     2881 ctcgaactgt ccgagcgccc caaagagatg gaaggtcagt ctcccggctg gggtggtggt
     2941 gtcaatggat tcggtcaggg accgaaaacc gcacccgcgt tgttccaggt cgttcaggac
     3001 ctcgatgagg tgggggagag aacgggccag gcgatccagt cgccagacgg tgagcacgtc
     3061 gccagggcgg aggaaggcca tggcctgcac caatccggtg cgttccgcct tggccccgct
     3121 ggcgacatcc tcaaaggtgt gttcgcaccc ggcatggttc agggcatccc gctgtaggtc
     3181 gaggttctgg tctccggtgg atatccgcgc ataaccgatc tgtgccatgg gtgtcgcctg
     3241 tgtgcgtcaa gtcgtcccac aatcatagcg tccgtctatc cgttgaaaca gggggttgtg
     3301 ggacgctttt gggggtgtcc gtcagaggat cgggatcacc cttcgtctgc cagagccgga
     3361 gtttcagcca tccgtcccca tagcgccaga cccgccgata ggtttcgcgc tcccagtcat
     3421 ccatccggtt gtgggcttga cggcgcagcg cccagaccgt gagatccagg cgaaagggcg
     3481 gtcgcgggct gaggcggaag tagtatccca tctatcggtc cagatccggc cgataactgc
     3541 cggcgggggt acggaaggca atggctaggc ggttccaggc gttgatggcc acgacggcca
     3601 aggtcagatc caccagttcc ttctcctcga aataacggcg gacgttttca tagagcgcat
     3661 ccgagacgcc ttcatcgatg cgggtgatag catcggtcca cgccagcgcc gcgctttccc
     3721 gctcgctgaa aaatggcgct tcccgccaag cggcgagggc ataaagacgc tgctccatct
     3781 cgccccgggc gcgggcttcc ttgctgtgca tgtcgatgca aaaggcgcag ccgttgagga
     3841 tggatgcgcg cagcttcacc agttccagca gcgctggttc caagttgctt ccatggagat
     3901 aagtctccag atcccgcagg ctgcggatgc cgttggggga taccaagcca tagtcgacgc
     3961 gtttttccat catggactcc tgtgggaacc ttcttggagc ggaaggggat ctggggccgg
     4021 ataccagatc ccgccatcgg gacgccgccg cgcccaaggg ctcaaacgat gcctctggtc
     4081 atgccctggc gtcagcaggt gatgccacgg taaaaccctg ggcggtaagg acgtcagcaa
     4141 tgagaaagcg atgacagcgc cacgggaggg tgctcggcgc acaggaggac cgtcctgcgc
     4201 ctacgcgacc aaggtgctcc aaggcctcca atcctttctg gaaaggcgcc gtctgcgcaa
     4261 gcgaccatat cggcagatac tgccaggata gagccagaag actgatctac cggcacagcg
     4321 cgaccattct aatcacggat gttcagaggt tccaaaggaa tatcatgagc gccacatatc
     4381 acgatccacg atacgctagg caggatggct agacaggccg cctccgcaga cggtatctga
     4441 tcctgagcga gcgttgccca tagtaagctt gcggggtatc ctctaactga agaacgacgg
     4501 cttgagactg gaagcagacg ttcggttggt gcgccaagaa aggcgcatcg aatctcctgc
     4561 cagtccaagg ttagtcagca ttgggcatga tctgtaagct cgcttgctat cacacctcct
     4621 aataatcaac tatgattgac gctggcggta caatccgatg aggaatggca acgtgaacaa
     4681 gcaagaattc ctatcctgct tcgttaaggg cctctaaaca tagcttctca tatcctagtg
     4741 gtgtcaattc aggttcttct ataaactgtg taatttcaac cttatgtttt tttatttcat
     4801 ctgccaatac attttcaagc atatcgtaca gcatattaag acttagttgt ttaatcccag
     4861 aatagaacga taccgaaatg aattttgaaa atatctcatt ttcagcaaga agcactttta
     4921 tcttatccac acaatcatct tttatactat ttatgttatc tttgctgtct ggaaatgctc
     4981 ccttagcata ttccttaaaa tccaatgagc ttgtatttag gaacaacgat tttatttctt
     5041 ttattgtgtt ttctatatcc tctccgaatt tattgtatat cacattttca aaaaaatatt
     5101 ccttctcttt taaccattcc tgaccgtcaa gaacatcata tttgacaacc cttaccccct
     5161 cgaaaaatct ttctgacagc tcgctgtaat gtgtcttgat gatatctgaa attttttgtt
     5221 tgtactcgtt attgtttatg gtgtattctt tagtcagttt tgcaacagaa aacgccatag
     5281 atgtgattat actctttatt tgttcttgct caaaataagc atttgaatca ttatcttcat
     5341 cctctatatc aacatcgcca tagtcagtta tgtcatcctc gtcatcaccg tcttcaaaaa
     5401 agaactttaa atcgccatcc tttagttgtt gaagggctat tattatatcg tcagatgagc
     5461 atgtcgtgct ttccttggcg ttatcatact gcgtcaagtc tttctctagt gttggagtaa
     5521 tacgtgttgc cttttttttc cagaaaaaca tataaaaggc tcctagattt tttattgaga
     5581 gcgataccag acaaaatgca tcctttggtc cggttccggc cggggaccgg agcagaaccc
     5641 attgattcca tgagagccga gagccgcaga aggccggcaa acatctgtcc ttacggtgaa
     5701 catggtcatt tccacaccga atccccgaat tcaccgtata gaagacctga tggcacccta
     5761 ggatatgaga gctatgttag tgccttaacg aagcaggatg gattctgaac taacaaaatc
     5821 ggaccggcga ccaaggtgct gatataattg caaaaaagaa tgataattct ttggtggtgc
     5881 agtgcaaata ttactccggt gggcgttgaa ccgaaagcag tccaggaagt tatcgctgcg
     5941 cgtacatatt attgtgctga ttatgccacc gttgtatcaa acacatactt cacacctggc
     6001 gcgaaagatt tagcaaaaag aggcgatgtt ttactattgg acgaaaacaa gttgaagaat
     6061 attgactttt ttttaaaaaa cagttaggct cttcgacgtt tcatgtgggt agcctcagat
     6121 ccagcttgcc caggatgagg taagccatgg cgatgaagtt cttgtgggtg cggtagccac
     6181 gggctttcgc cttggcggac tggaggaggc tgttgaagcc ctccaggatg ccattgctga
     6241 cttggctctc gaaccagcgg aggaccccgt cccaatggtt catgagggtg taggcgaccc
     6301 tgacgatagg cggcagatcg ctggttctgg cgttttccaa ccaggctttc aagagggtag
     6361 ccccctggtg gcgattcttg atcgtgaaga tgtcctgaaa ggtcaggcgg aactggtagg
     6421 cctgcgccgt cttgaggttc tggtctttga gcaattcctg cagcttttct ttctgcttca
     6481 ttttgaggtt gcaatcgttc ttgagccaaa gccagcgggt ctttttgaga tttggctggg
     6541 tgaggacttc ccccttgcgc acgtcgtcta cggcctcgtt gacgagcttc atgaggtgaa
     6601 aacgatcgaa agtgatctcc gcattgggca ggtgctcggc agcccctttc tggaaggccg
     6661 gcgagaggtc catgctcaca tcggtgatcg cttccgcgct accaccatgg gcctgaagat
     6721 ctccggagaa tttctcaaag gtcttggcat ccttgccggg agtagcgaac aagagtcgcc
     6781 gggcattcag atccacgaag agcgtgatgt agtcatgtcc atgccgactg ctggtttcat
     6841 cgacgccgac ggcatggaca ttggccatat ccaccgcagc acgagcttcg ggcacataat
     6901 ggtcaatcac tcgccacagg agcttgtcgg tctcaccgac catgcgagct gccgtcaata
     6961 ccggcatctc ccgcaccagg gtcatgatca gcgcttcaaa gagcagggtg aaacgcgagc
     7021 cttcccgcgc ccagggaaca gatatctgat gcactccatg ctcctggcac ttcacacgag
     7081 gtacacgggc atggagatag gcttcatgct ggaagaaatc catgtgccgc caggtatggt
     7141 cacgggtatc atgtaccgga cactcctcac cacagacgga gcaagcaaag cgactacctt
     7201 tgggaaagtt gatgtgcaga tccaggcgtt tctcctccac cgtgaaagtc acatgatcca
     7261 ccaaccacgg cggaaccaat cctaacgcga gagaaaacag ctcttcaggg accatcagct
     7321 aactcctatt cagggcacga ccgctccaca gcattctacc ccctacccac tcaatctgac
     7381 gaagagccat aaggaaggat ctcgatatca taagtttcca gtgatgtgaa tcgttctttg
     7441 gtgccatcca actcccatag aatctggctg tctctaagcg cacgtaatcc atacagccag
     7501 aaatcaccgg gcatgtcgct cgggtctaac ctaaactgca tgctcccggc atggatgctg
     7561 aagacaatct gatgcctttc cccatctagt ggatatggtt tactattact tctgtgctca
     7621 tcgaaaccat ctttcttttt ggaccagtat aaggttgtgt ttgcgctcaa tgtcctatta
     7681 tttgtaatca ctgcgggagc agtgattagg ctggcctttt cctgctgtac cgcctccaat
     7741 ataaactggt agacggaccc atcttcagaa cagaagatgt tctggactaa agcttctgga
     7801 caaggtaaaa aaagcgaaat gtgcgtctga tccaagcaag tcctttaggg gtcgggtagc
     7861 ggaaagttct ccatccaaat agttcaagga tgacgccgat atgcccaaca ttagggatga
     7921 aatcaagaat ctaccttcag ctattagtag gtcttgcagg aagctgcaac aatcttcccg
     7981 gttcccgaag gtgctccaga atgtcggcgc agacgatata gtcataacgc agcttctgaa
     8041 gattgcgcgg aagatgctcc cgctccagat cccactccca taagtgacga tagaagggtc
     8101 gtgccgcttc tagttcaatg tgattggcat cgataccatc caccacgcag tgcagacttt
     8161 cactcaggta cttccccaac gtgcctacac cacaaccaac gtccaggaca aggctgccgg
     8221 gctgaatgcg tcgggcaatc tttgcaagac tatcttggcc ctgaggatct atcgggggac
     8281 gattataaac atgcggggta tgtgggactg attcatacgg gatccggatc cttgtggaga
     8341 aattgtcaga cagggcagtt gcaagatcga ggcgcaccca ctgtccgaaa gtaggccaag
     8401 cgccttctgg acaggagcag agatcgcacc tctggggcgg ggcgggccgc ggggtgtgtc
     8461 tgcaagggcg aagcccgcgc agcgtagcga agtttttgcg ggacttgtcc gcccaatttg
     8521 ttcactgatg ctgctttgtc tctgcctgct cgatggctcc gatatccagg cggccatagt
     8581 atacggtttt cccatcgtgt ttctcgtatc caaagttatt tgctacgttg gctgccacat
     8641 caatgggtac gcaagggcca gactggatgc cgtcgaacgc agggcactct tggacaatac
     8701 caccgatgcg cgtttggatg gccgcttcct cggccttgag acgttgcagc ttttgttcga
     8761 cctgccggac ttcttttgag tgccaccaga tatcgacctc tccggcagcg tatgacccaa
     8821 tccccacgac tacaagcacc agcccggccc agacggatct cgaccaaagc gtttttccca
     8881 agtcactgcg gaaggcatcg acgagctgct gtccagcttt ggacagcagt tctgatgacg
     8941 cggcggagat tcttcccttg gctgcttctt cggcgttact ggcgatttta tttgccgtgt
     9001 tctccatggc cttgggcagt ttgctgaacg tcccatagta ggcatccaag gtgaccagga
     9061 tgggaaacat ggcatcgttc tgcggaatgt ccagggcatg cgcgatggcg gagaccctgt
     9121 tgatgtcttc gggtgtcggt tcccgcccgg tgatgagtcc gatggctttc ttcagatcac
     9181 tcataagccg ccttcaatgc ggtctgtgcg gcctctcgat agcggcgcag tgcggagcgt
     9241 tccgagatgg agagcttggt atcggcgctg cccagagaaa gccggttgtc cacgagtttg
     9301 tcggccacca gatcgtttag ctctggaaat atcacggttc cggaaacacg gtttttcaga
     9361 gtgctgttgg caaaccgggc aaatttttca ggtgccccga aatacgtgtt caacacggca
     9421 taggtggcat ggtagggctt ggccgtttcc agaaaatctt tcaacaactc cagcgagtcc
     9481 cgttgccggt tgatgggcca gagcatgatg agttcccggt tctgctcctg tgccacatcg
     9541 ttcaggatgc cgccatactg gatgagtgcc gaagtggccc gcgctgcggt attgaccacg
     9601 atgctgtttt tggggtggtt ctcgatgatg ttaccgagat ggatatatcc ctcttcggta
     9661 tccaggttgc agatatggca aggcagcagg tctttgaggg ccttgtaggt atcgggattg
     9721 ctgtcgtcac tctccaccag aacacaggaa tgactcccgg agagcagtgc atcgacgaga
     9781 gccattgtca cggtggattt tccgacgccc cccttgccac caccgacgac cagtatcttg
     9841 ttgagagact tgctcataag tcctccgaat ccggtttgac cgtaaaggtt ccagcctgcg
     9901 ggataggtgc tgtgttcgct tggccggacg ctgttggcgc cggtgtggtg gattttttct
     9961 ttctggtgac tgttgatttg ttctgcttct ttcctgcaac gatctcagtg atggttttcg
    10021 gtagtatacc gaacacgtca tcatgcttca gggcatccgc aatctgtttg ctggtgtagc
    10081 ctttcttgat caaggcttcc aggtcactct tgatcgctct gatgacatcg gctttcccgc
    10141 ctttgccggt gacttctccg ggctgctggg ttttctccag attttccagt gcagtccttg
    10201 cttttttcgc gtatgcgtct atatcgtaga gttgtttcga gcttgccatc ctgtcgttcc
    10261 tcctgtgccg gttttcttaa gctttgcata gattctactt cattgacttt cgtaaagaaa
    10321 gcactacaat acgtataagc tatattttga acaggatggg acttgtcata cacatgctac
    10381 gcatgttccc gccaagccac gcccaaccat tcggcgctac gcttctcacg gtccggctca
    10441 tcctgcaaag ggcaagcccc ttgaccccgg ccagcgcggc gccatggctt cttgctgacc
    10501 cagacacacc ccgccgccgc gaaaggagac acgatgccat ttaccgtgca aggactggaa
    10561 cctctggatg cggtcgtcaa tgtccggcta accgcatcgg agaaagcgcg tctacgggag
    10621 gatgcggacc tcgccggatt gagtgtttcc gagctggtgc gccgccgcta ctttggcagg
    10681 ccgattgtgg ctcatgcgga tgcggtcttg ctcaaagagc tacgccgcat cgggggattg
    10741 ctcaagcatg tacacaatga aagcggtgga gcgtacagcc agcaaactgc cgccgttctg
    10801 gtcactttga aagccgccat cgaggggctg agtcatgatc gttaaaaagg tcaagagcaa
    10861 tcgaacaaag ggcaaagcgg cgagtatacg cgatctgact aactacatcc gggagccgca
    10921 gaaccggaat ccaaatgaga aggtacttta cgcgaacgga cggggtttca tcagcgacac
    10981 tcatgccgcc cagcgggagg aaatggtagc cctggcagcg gaagcggtac gcagccgcaa
    11041 tccggtcaat cactacatcc tgagctggcg ggaaggggag cagcctagcc cggagcaggt
    11101 ggaagaagcg gtaagcatct ttctggatga acttggcttg caggaacacc aggttatcta
    11161 cgccctgcac aaggacacgg ataacctgca tctgcatatc gccgtcaatc gcgtacaccc
    11221 agaaacgctc aagtgtgtgg agatcaacaa gggctttgac cttgaatccg cgcatcgagc
    11281 tattgcccgg attgaacatg cacagggatg gcaacgggag cagaacgggc gctatgaagt
    11341 gttagagaat ggcgagctag gacgagaaca cctggaacca aacaagcgac gccaaccgga
    11401 gcagcgcaag cgggacaagg agaaccgcac cggggagaaa tccgcggaac gtatcgccat
    11461 tgagatcggt gcgccgatca tcaagcaagc gcaaagctgg gaacagttgc accgggaact
    11521 ggcagcacaa gggatgcgct acgagcagaa gggcagtggc gcattgcttt gggtcggtga
    11581 ggtagcggtc aaagccagca gtgccgaccg ggaagcgagc ctcggcaaac tgcaaaagcg
    11641 gctgggcgcc tatgaacccg cgcaagcacc ttcgcctgtg gcgcaacgga agccggaacc
    11701 gcttcaaccc gacaggccgg agtgggagga cttcatggct ggacgcaaaa tgcactacgc
    11761 agaaaagaac gcggccaagc tctccatgga ccagcggcag gaacaggaac gcaaggcatt
    11821 gcaagcgcgg cagcaggaac aacgcaaggt actcctgggc ggacgatgga atggcaaggg
    11881 agaagcgctg aacgcgctgc gcggcgtgct tgccgcagaa caggccgcgg agaaagccgc
    11941 cctgaaagaa cgtcaccagc aggaacggca acagtggcgg caacagtacc gcccgtatcc
    12001 cgacttcgag cagtggttac gacgcgagca cggggcagaa caggcgacta ggtggcgcta
    12061 ccgggaggcg gaaccgcaac gcatcgaggg cgactcgacc gaagcgccga aacctcggga
    12121 cattcgcgcc taccgggcgg agatcgtggg acaggaggtc cgttacaccc ccaagagtgg
    12181 cgcgggcggc gggccggggg gtgtgtcttt tgtggacaag ggcaggatca tcgaaatcca
    12241 cgattggcgg aaccaggaca ccactcttgc ggcgctccag ctctcggcgc agaaatgggg
    12301 caagttcacc gtgaccggga acgacgaata caaagcgctg tgcgtgaagc tggcggtgga
    12361 gcacggtttc cagatcacga acccggagct tcaggaggtc attcggcagg aacggcaacg
    12421 gatgcggcag gagagggcac aggcgatgaa atcggagcag atcaagccgt tcgagcgata
    12481 cgccgaagcg gttggcgccg agcgctaccg ggtgacaagc atcaaaatgc ggccagatgg
    12541 cagcaagcaa accttcattc tcgataagcg ggacggtatc acgcgcggct tcacgccgga
    12601 agaaatcgcc caaaggacgc ccgaaatgca gcgtttacag cgccggggcg aaaacctgta
    12661 ttacacgccg ctctccgaag ggaaacacca tatcctgatc gacgacatgg accgtgagaa
    12721 actggaccgg ctgattcgtg atggctatca gcccgccgtc gtgctggaat ccagccccgg
    12781 caactatcag gcggtcatca ccattccgaa gctggggacc cccttcgaca aggacgtggg
    12841 gaaccgcctg agcgatgcgc tcaaccgcga atacggcgac cccaagctgt ctggtgccat
    12901 ccatccgcac cgcgctcccg gctacgagaa ccgcaagccc aagcaccggc gggaagatgg
    12961 cagctatccc gaagtgcgtt tgctcaaggc cgagcggcgc gagtgcggca agacgctggc
    13021 gctttcccgc gagatcgacg ccggatatca gcggcaggcc gccgagaagg ccctgaaaac
    13081 gcccgtagag caattttcgg agccaaacag tacccagacc acccctgtct ctgaaaaaac
    13141 cgccacagag gcttattggc ggcattaccg cgatgttcgc aagcgccaac gcggaatgct
    13201 ggacctgtcc cgcgtggacg ccatgattgc cgtgcggatg cgcgttaccg gctttgacca
    13261 gtcggctatt gagggcgcca tctaccagtg tgccccatcg atccgggagc agcaggaaag
    13321 ccgggactgg accgactacg cccgccgcac ggcccgctat gcctacagcg ccgcaggtga
    13381 ccggcaggcc gccgacctgg gtaagtaccg ccagcagtgg gagaagctgg aggggcgcga
    13441 gcggcagcag gagcaggcca aggcgcggga gattgagcgc aacgggccga gtatgagtcg
    13501 ttagtattct tcacagcggc atgatatact tgtatatcat tttgagcagg agctaaacat
    13561 gcttgccatc cgattaccca ccgaagtgga aaatcgcctt gaggccttgg cgcaggccac
    13621 aggacgcacg aaaacctttt acgcccgcga agcgatcctt gagcacctgg acgacctcga
    13681 agatttgtac cttgcagagc aacgcctgat cgacattcgc gcaggccgaa gccgtaccta
    13741 cacgctagag gaagtggagc gcgatcttgg cttggcggat tgagtttgat gacaaggcca
    13801 agaaagactt ggctgcgctg gataagagcg ttgccaaacg catcacggct tttctgcgag
    13861 agcgcgtcgc ccatctagac gacccgcgca gcattggcga agccctcaaa ggctccaagc
    13921 tgggagactt ctggaagtac cgcgtagggg attggcgaat cattgccagc attgaggatg
    13981 aagccttgcg tattcttgtc gtgcgtattg gtaaccgccg agaggtatac cgaaagtaaa
    14041 caaccccggc atgaagggcc ggggtttccc gcgcaaccgg atgaaaggac ggcgcgagcc
    14101 ggagtgtcag tccccggcag cgcctaacca cgccagttct ggaaaggaga acagc
//
