LOCUS       Tn6855                 15689 bp    DNA     linear       29-SEP-2020
DEFINITION  Klebsiella pneumoniae.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Unclassified.
REFERENCE   1  (bases 1 to 15689)
  AUTHORS   Zhou,D.
  TITLE     Complete sequence of Tn6855
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 15689)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2020) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
FEATURES             Location/Qualifiers
     source          1..15689
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
     repeat_region   1..18
                     /gene="attL_Tn6855"
     CDS             81..1370
                     /gene="int1"
                     /codon_start=1
                     /product="Site-specific integrase"
                     /translation="MATLERIHFVPHYLVRRENAVAYSPSSSRPSIEGLPQIFWADYA
                     PWREANLWAVERATTGDASLKTVASNMNGLLNYAKFLESRDLQWFEFPARKADRCLVL
                     YRGALIKMRDAGQIGPSTASEYMRNCIMFYRWVRHRELLSPHVQLWREKPYVVKYFDR
                     VGFERTISGTTTDLSIPNRKRPGQTLEDGLLPVSETDRDAILDFAAENATPELYLMLA
                     LGFFTGMRLGSICDLKIQSLERAAPDPSAEGLLRLAVGPGAAPPVHTKFGVTGQVWIP
                     EALRDELLEYAKGWRRMEREAKASPENRDLLFLTRFGNAYGRRGTDQSSAVNVEMSEF
                     RKRGVKAELQVLRKFRFHQSRCTFGTELARLALSACADVAIVIATVSDALLHGPNSEA
                     TTFKYIRFVQALPIKQALSNSFMAAFSGIGAGARHDG"
     CDS             1363..3093
                     /gene="int2"
                     /codon_start=1
                     /product="Site-specific integrase"
                     /translation="MDSSEFDLTFPMLEYGATETPWDLRPLLFRGGAAAKVKHVGRQI
                     AQGELGSPLPERFELVTQLHEHMTDDLAGGGSRFSVQNKISALRRFFAWIDSENVNLS
                     LETAADTFIRWTDHLLQRHRVERNFSDGSLYDLTRLTATMLDRALDRQASLSKSTRIR
                     KPRGKGKVHTSKADKQNLQNTFAFGHLLADVCEALTWRGTMAPLPVCISLRTGQVLEL
                     WSGLQSPEKVAARRTRPQNQAQIEASLAARAAHDADRTLRTRFPIVNLRIESELLMFI
                     AQTGLNLQQAHTLRVEQFHYTSHIDGYQVRTYKNRREGEVLFEIFASYREWFERYLEW
                     RSEWFPNEPDGLLFPLIRSGGRILEEATQFTNVTRICRELGIPIVRPRKLRGTRINWL
                     LRESQNPQQVAELAQHTVQTLIRVYADPHPQIAMVEITRFHQQTDPSLSPPAPGRCVS
                     ATPEPVGTMPKNGPRPDCINAAGCLFCTQHRDIESEDHVWSLGSLRHLKSLELARYRP
                     SSSGKHLTTEHPALLVIDRLTAKLRFFEESSEVRRLWVEEARARISEGDYHPAWDGFI
                     RLAELRQRSA"
     CDS             3090..5129
                     /codon_start=1
                     /product="Hypothetical protein"
                     /translation="MTKNILSELGLGIDSPLAIPDAPNYRPPCWPPQRDWPVIIDAAG
                     QVVSRWGDAIWRLDPWAGKRLTLNFGDGPAKKYVAAIDPANADLLRTVIGWWLYGPNG
                     ARGYRGLKTRFDQMRRLFVLCTQEGILASELSHFPRVADRLPEVLQASRSGEFLALLH
                     ELYERRDALGFTLLDRAGLARLAAAMPDHQKLQTPYIPPRIWHYQITRLRECLDDFLA
                     HRGQVEECFRFCLAAYRHNSASLQGQRRPQSFYPFQWPSDGSNGKWTGRQYYGPFIDT
                     AHRFGMVELFRRWLGVSDDEIRIQTLSRYLNLVSRSGLCYLLNFSLMRVEEAWNLRAD
                     CLHIERDPQFGDIHVLCGRTTKTMSDSEALWVTSPSAQVAVEAMRVVADLRAECDSPP
                     GEASVPDDPAKRYLLDYCLEPWGTKFTKINRTIRPSIPSYAHVLQWFDKLFDREQLRI
                     TPEDFELARLVTPTLTDEFAVGKIWPLAWHQLRRTGAVNMQASGLVSDASLQFQLKHV
                     ARAMSLYYGQNHSRVRLEEKAHTYYVRTMYETLGRQLQQLTSNRFVSPHGEKRKSEIV
                     RLISASDAKKAINLAKKGTVTHRPILLGICTSRTPCPYGGIDNIARCGGGDSPGETKP
                     CADVLYDPEQLDEVEVLEAVLDERLAAAEVDSPLRTSLEAQKRSVENYRHVIRQT"
     CDS             5110..5574
                     /codon_start=1
                     /product="Hypothetical protein"
                     /translation="MSSGKHESADPAKRMSAGEQYRAAFERLKSNKPERLPKGTPVSQ
                     NNVAKEAGSDPSALKKARFPLLIAEIQKYVEGHAEQRPPSVRQVSLLARRKNRGLRER
                     IEEITQQRDHLASLLSEADATILELYDRIADLERQLPASNVLPLDPRGHKKL"
     CDS             complement(5642..8332)
                     /codon_start=1
                     /product="AAA family ATPase"
                     /translation="MPLLDEIIGWAGGLRPWQQEALRRIFARAELTQDDIETILRMVR
                     EQEREDATTGGARPFTLDDVPGAGSGATVRLVGVSGLDQVNGFPSGRAFDLAPEGMTI
                     FFGHNGAGKSGYARVFKNACNARHRVEVLPDAFGAATPARLPSADFAILVDGTPETAR
                     WVQNGPAHLHLSSVSVYDAACANDYIDAEGTPAFQPYGLTHLTRLVLLQRDLQARIGT
                     ERNALALDTRQFEPLKGDTEVGRYIAKLGGDSDRAVLARLGTVGDDELRRLEFLKRTL
                     LESDPVPQALALERLATRLDQAQRRAEEVQRWVNDRAIARAKELITTEKTAHLAMQLA
                     QARLQDRDTLNAMELPVTSSPTATLLEGTGAELWQTMYRAAEAFSQQTAYPEHPFPHL
                     EPDAYCVLCQQPYSTDASERMRRFAAFVADSATADAQAATLARMNALGKVQAVDLNVL
                     DVPTRADVEERLPDLHAAITAAASVWTARHTWVSQALQTGNWSPESEPLPIEANLDSL
                     FAAKAASLRVDANTLRTSADPALRLALTQELAELEARQRLANQLGAVERFVQDSQVHA
                     TLSRCHAALNPAAVSRKLTSLAATHVTEALAASMNAELKALGYKRRVQPDLSGRTELG
                     VTKVTLRLQEITAKASKVLSEGEQRALGMAMFLAELESLPHTSTVIFDDPSTSLDHVY
                     RRAIARRLVALAETRQVLVFTHDAVFLTELAMALQRADRSASYKTIGWDESPGLVSEG
                     LTWTTMDTKARLADLESRAKALNVPVGSDPDDELERQIASGYSSLRGTVERAIREVFL
                     NNTVQPFSDVVSVEAFGAVIGHPAEEWEQLLAVYARACEATEAHDTPGERQLPLPARE
                     ELLGDIAQVLELIKNATKRRTAYENLRRERTAQRKKLFGG"
     CDS             8387..8638
                     /codon_start=1
                     /product="Hypothetical protein"
                     /translation="-
                     ASAFEVLRRVPFACLPDRHPSGLSGRDATRAEFLHAGQYQAALKSATGKRCLAVRDGE
                     SAEATTDASDVVSSPQVCAKLHSS"
     CDS             complement(8773..9330)
                     /gene="nfxB"
                     /codon_start=1
                     /product="LacI family transcriptional regulator"
                     /translation="MDLTAADEKLLKALAIAIVDHPRATFKEIAQAAGVSKARLNRFC
                     GTRDNLIEMLLNHGSVVIYRVIADADLEAAPLDALHRLIEGHLIHRELLVFLSFQWRP
                     DTFDLDAGGCRWLPYSETLDEFFLRGQKLGVFRIDIGAPALTEIFSSLIFGLVDAERR
                     GRIARAGMAALIEQFFLNGACNYQT"
     CDS             9510..10673
                     /gene="mexC"
                     /codon_start=1
                     /product="Multidrug efflux pump subunit"
                     /translation="MNKFREWITFSVISCLVAVTLVGCDKPEEQREEAPAREVDVLSV
                     KTEPFTVFAELPGRIEPVRVAEVRARVAGIVLKRTFEEGADVKAGDVLFQIDPAPFKA
                     ALSRAQGELARAEAQLFQAQAMVRRYEPLVKIDAVSQQDFDNAMAALQSAQADKRSAQ
                     ANVETARLDLGYAEVRAPIAGRIGRAQVTEGALVGQGEATLLARIQQLDPVYADFTQP
                     AADALRLRAAIAEGKVAGASDQPLSLRVDGTDIERKGTLLFTDISVDRSTGQIALRGQ
                     FDNPEGVLLPGMYVRVRTPQGLNQNAILVPQRAVQRSADGQASVMLLGEGDTVEVRQV
                     TTGAMQGSRWQISEGLQAGDKVITSSLAAIRPGAKVIPREQGAAEKAPQSQAQ"
     CDS             10689..13823
                     /gene="mexD"
                     /codon_start=1
                     /product="Aminoglycoside efflux pump"
                     /translation="MPLFFIRRPNFAWVVALFISLGGLLVIPFLPVAQYPNVAPPQIT
                     VTATYPGASAQVLTDSVTSVIEEELNGAKNLLYFESTSNANGIAEITVTFQPGTDPEL
                     AQVDVQNRLKKAEARMPQAVLTLGIQTEQATAGFLLIYSLRYKDGDKNANTTALADYA
                     VRNVNNEIRRLPGVGKLQFFDSEAAMRVWIDPQKLVGYGLSIDDVNNAIRTQNVQVPA
                     GAFGSTPGSSEQELTATLTVKGTLDNPEEFAAIVLRANQDGSRLTLGDVARIEVGSQD
                     YNFGSRQDGKPAVAAAVQLSPGANAIQTAEAVKQRLTELSANFPDNVEFSVPYDTSRF
                     VDVAIDKVIMTLIEAMVLVFLVMFLFLQNVRYTLIPSIVVPVCLLGTLTFMYLLGFSV
                     NMMTMFGMVLAIGILVDDAIVVVENVERIMAEEGLAPVPATIKAMGQVSGAIIGITLV
                     LSAVFLPLAFMAGSVGVIYQQFSLSLAVSILFSGFLALTFTPALCATLLKPIPVGHHE
                     KTGFFGWFNRKFTSLTSRYTKLNDKLVPRAGRVMFIYLGVVVLMGFLYMRLPESFVPV
                     EDQGYMIVDIQLPPGATRERTSAAGGELESFLMAREAVQTTFLVLGFSFSGMGENAAI
                     AFPLLKDWSERDSSQSPEAESAAVNQHFANLDDGAIMAVPPPPVEGLGNSGGFALRLQ
                     DRAGLGRDALLAARDEVLGKVNGNPKFLYAMMEGLAEAPQLRLVIDREQARTLGVSFE
                     AISSALSTAFGSSVINDFANAGRQQRVVVQAEQAERMTPESVLRLHVPNDSGSLVPLS
                     AFVTTSWEEGPVQVARYNGYPSIRIAGDAAPGVSTGEAMLELERIAAELPEGIGYEWT
                     GLSYQERVASGQATMLFALAITVVFLLLVALYESWAIPLTVMLIVPVGALGAVLAVTA
                     IGLPNDVYFKVGLITVIGLAAKNAILIVEFAKDLWEDGYSLRDAAVEAARLRFRPIIM
                     TSMAFMLGVVPLAIATGAGAASQRALGTGVLGGMLSATMLGVIFVPIFFVWVLSLLRT
                     KPQQTDNHPLHKAE"
     CDS             13828..15261
                     /gene="oprJ"
                     /codon_start=1
                     /product="Outer membrane channel protein OprJ"
                     /translation="MTSHFMLRRALLPLAIAALAGCSLAPTYERPQAPVASHWQAADA
                     EGARAQALDWQTFIVDADLRRAVDTALSNNRSLRQALLDIEAARAQYRIQRADRLPSI
                     NANASGNRQRLPADLSQTGRSEVTSNYQVGLGLAEYEVDLFGRVRNLSEAALETYLAT
                     EEATRATQISLVAEVIQAYLTRDGALRRMALVEQTLDSRMASLELVSQRRAAGAATAL
                     DYQEAVGLAEQARAERESTERQLRQADNALVLLLGTPDAARLLPATPRDDLMVLQDIA
                     PGTSSELIERRPDILASEHRLKARNADIGAARAAFFPRISLTGSVGSSSAELSGLFDG
                     GSRAWSFAPTLSLPIFAGGRNRANLDLAEVRQDAAVADYEGTIQTAFREVADALAATD
                     TLRREEAARQALAGSSEAAMALAKARYEGGVDDYLRYLDAQRSTFSNQTTLIQISTER
                     QIALVDLFRSLGGGWGQTEPMAGIGAE"
     repeat_region   15672..15689
                     /gene="attR_Tn6855"
ORIGIN      
        1 taagagtaag ttgtatagtg cggacgccta agctattgag ttctatctat ggacattgtt
       61 aagcgtccca ggggcgttga atggcgacgc tagagcgcat tcatttcgtg ccccattacc
      121 tcgtgcgcag agagaacgcc gtcgcatact cccccagtag cagccggcca tccattgagg
      181 gcttgcccca aatcttttgg gcagactatg caccttggag ggaggcaaac ctgtgggcag
      241 tggagcgagc aacgactggt gacgcttctc ttaagaccgt tgccagtaac atgaatggcc
      301 ttctcaatta cgctaaattt cttgaatctc gtgatttgca gtggttcgag tttcccgctc
      361 gcaaagctga ccgctgcctg gtgctatacc gaggggcgtt gatcaagatg cgcgatgccg
      421 gccagatcgg cccatccacg gcgtctgagt acatgcgcaa ttgcatcatg ttctatcggt
      481 gggtaaggca tagggagctt ctttctccac acgtccagct gtggcgggaa aaaccctacg
      541 tcgttaaata cttcgaccgg gtggggttcg agcgaacgat cagcggaacc accaccgacc
      601 tcagcatccc gaaccgtaag cgcccaggcc aaacgcttga agatgggctg ttgccagtct
      661 cggagaccga tcgcgatgca attctggatt tcgccgcaga gaacgccacg cccgagctct
      721 acctcatgtt ggcccttgga ttttttaccg ggatgcggct cggcagcatc tgtgatctca
      781 agattcagtc tctggagcgc gccgcccccg acccttccgc tgaagggctt ctacgccttg
      841 cagttggtcc aggcgcagct ccgccagtgc acacgaaatt cggtgtgact ggccaggtct
      901 ggatacccga agcgttgcgt gatgaattgc tggaatatgc caaaggctgg cggaggatgg
      961 aacgagaggc gaaagcctcg cccgagaatc gtgatttgct gttcttgacc cgctttggta
     1021 acgcctatgg caggcgcggc accgatcagt catctgctgt gaatgttgag atgtccgagt
     1081 ttcgaaaacg gggcgtcaaa gcagaactac aggtgctccg taaattccgc ttccatcagt
     1141 cgcgctgcac cttcggtacc gaattggcac gtctggcgct atcggcttgt gccgatgtcg
     1201 ctattgtaat tgcgacggtc agcgacgcgt tgctccatgg gcctaactct gaagccacca
     1261 ccttcaaata catccgattc gtacaggcac tgccgatcaa acaagccctc tcaaatagct
     1321 tcatggcggc atttagcggg atcggcgctg gggcgcggca cgatggatag ttccgaattc
     1381 gacctcactt tcccgatgct tgagtatggg gccactgaaa cgccctggga cctccggccg
     1441 ctgctgtttc gcggaggtgc agcagcaaag gtgaagcatg tgggccgcca gatcgcgcag
     1501 ggcgaactcg gcagtccctt gccggaacgt ttcgagctgg tgacgcagct gcatgagcac
     1561 atgactgacg accttgctgg tggcggaagt cgcttctcgg tgcagaacaa gatcagtgca
     1621 ttgcgccgat tctttgcctg gatcgattca gaaaacgtga atctcagtct cgagacggcg
     1681 gccgacacgt tcattcgttg gaccgatcac ttgctccagc gtcatcgagt cgaacgcaat
     1741 ttcagcgatg ggtccctgta cgatctcacc aggctcacgg cgacgatgct ggaccgagca
     1801 ttggaccgcc aagcaagcct gagcaagagc acacgtattc gcaagccgcg cggcaaaggc
     1861 aaggtacata cgagcaaagc ggacaagcag aatctgcaaa acaccttcgc attcggacac
     1921 cttctagctg acgtatgcga ggcattgacc tggaggggga caatggcccc cctcccagtt
     1981 tgtatttcgt tacgcaccgg ccaagtgctg gaactatggt cgggattgca gagccccgag
     2041 aaagtagcgg cccgccgtac caggccgcaa aaccaagcgc aaatcgaagc atccctggcg
     2101 gcgcgtgccg cccacgatgc agatcggaca ctgcggaccc gtttccccat cgtcaattta
     2161 cggatcgaga gtgaattgct gatgttcatc gcccagaccg gtctgaacct ccagcaagca
     2221 cataccctgc gggttgagca gtttcattac accagccaca tagacggcta ccaggtacgt
     2281 acctacaaaa atcgacggga aggagaagtg ctattcgaga tctttgccag ttatcgagag
     2341 tggttcgagc gctatctcga atggcgttcc gaatggtttc ccaatgagcc ggatggtttg
     2401 ctctttccgc ttatacgtag cgggggacga atcctagaag aggcgacgca gttcacgaac
     2461 gttacgcgca tctgccgcga gcttggcata ccgatagtga gaccgcgaaa actgcgcggg
     2521 acgcgcatca actggttgct tcgggagtcc cagaatcccc aacaggttgc ggagttggcc
     2581 cagcatacgg tgcaaacgct gatacgcgta tatgccgacc cccatccgca gatcgctatg
     2641 gtggaaatta cgcgcttcca tcagcaaacc gatccgtccc tttcacctcc tgctcctggt
     2701 agatgtgtat cggccacacc tgaaccagtg ggcacgatgc cgaagaatgg tccgcgaccc
     2761 gactgcatca atgctgccgg ttgcctgttc tgtacccagc accgggatat cgaaagtgag
     2821 gatcatgtgt ggtctctcgg tagcttgcgc cacctcaaat cgcttgaact ggcacgctac
     2881 cgcccatcca gttcgggtaa gcacctgacg acagagcatc cggccctgct ggtgatcgat
     2941 cggctgacgg ccaaactgcg cttcttcgaa gaaagtagcg aggtccgcag gctttgggtc
     3001 gaagaagcca gagcgcgcat aagtgaaggt gactaccacc cggcctggga tggcttcatc
     3061 cgattggcag aactgcgaca aagatcagca tgacgaaaaa tattctttcc gaacttggcc
     3121 tcggcatcga ctcgccccta gcgattcctg atgcgccgaa ctaccgtccg ccgtgctggc
     3181 caccgcagcg tgattggccg gtcatcatag atgccgctgg ccaggtggtg agccgttggg
     3241 gcgatgccat ttggcggctc gacccatggg cgggaaaacg gctcactctc aatttcggcg
     3301 atggcccagc taagaaatat gtcgccgcga tcgatcctgc gaacgccgat ttattgcgga
     3361 ccgtaatcgg ctggtggcta tacggcccca atggagcccg tggataccga ggcctgaaaa
     3421 cgcgcttcga ccagatgcgt cggctgttcg tcttgtgcac tcaagaaggc attctcgcat
     3481 ccgaactgag tcattttccg cgcgttgccg accgtctccc ggaggtgctc caggcttccc
     3541 ggtccggtga gttcttggca ttgctgcacg aactgtacga gcggcgggat gcgctggggt
     3601 tcaccttgtt ggatcgcgca gggttggcac gcctcgcagc ggccatgccc gaccaccaga
     3661 agctccagac cccctatatc ccgccccgca tttggcacta tcaaatcaca cgcttgcgcg
     3721 aatgcctgga tgactttttg gcgcatcgag gccaagtcga ggagtgcttc cgcttctgtc
     3781 tggctgccta tcggcacaac tctgccagtc tccaaggaca acgcaggcca caatcgttct
     3841 atccgtttca gtggccgtcg gatggatcaa acggaaagtg gactgggcgg cagtactacg
     3901 gcccattcat cgacaccgcg catcggtttg gcatggtgga actatttcgt cgctggctgg
     3961 gagtgagcga cgacgaaatt cgcattcaaa ctctgagtcg ctacctcaac ctcgtgagtc
     4021 gatctggact gtgctatctg ctgaacttca gcctcatgcg agtcgaagag gcttggaacc
     4081 tgcgcgccga ttgcttgcac atagaacgtg atccgcagtt tggcgacatc catgtattgt
     4141 gcggacgaac gaccaagacg atgtcggatt ctgaggcact ttgggtgacg tccccgtcag
     4201 ctcaggtggc agttgaagcc atgcgtgtgg tcgcagacct ccgcgcagaa tgcgactctc
     4261 cccccggcga ggcctcggtg ccggatgatc cggccaagcg ctatctgctt gattattgcc
     4321 ttgaaccgtg gggaacgaag ttcaccaaga tcaaccgcac gattcggcca tcgattccga
     4381 gctatgccca tgtgcttcag tggttcgaca agctgttcga ccgtgagcaa ttgcgcatta
     4441 cgccggaaga tttcgaattg gctcggttgg tgacgccgac gctgaccgac gagtttgcgg
     4501 tcggcaaaat ctggccgttg gcctggcatc aactccgacg aaccggcgca gtgaatatgc
     4561 aggcatccgg gctggtcagc gacgcttcat tgcagtttca gctaaagcac gtcgccagag
     4621 cgatgagtct ctactacggg caaaaccatt ccagggtacg gctggaagag aaggcccata
     4681 cctactacgt ccgcaccatg tacgaaactt tgggtaggca gctgcaacag ctgacgagca
     4741 accgattcgt cagcccccac ggcgagaagc gaaaatctga gattgtccgc ctaatctcag
     4801 cctctgatgc taagaaagcg atcaatctgg ctaagaaggg gacggtcact catcgaccga
     4861 ttttgctggg catctgcacg agccgtaccc cctgtcccta tgggggcatc gacaatatcg
     4921 ctcgctgcgg agggggcgac tcccccggag aaaccaaacc atgtgcggac gttctctatg
     4981 accccgagca actcgacgaa gtcgaagtgt tggaggcggt attggatgag cgcctggccg
     5041 ctgccgaggt agacagtccg ctaaggactt cgttggaagc ccagaaacgt agtgtggaga
     5101 attatcgcca tgtcatccgg caaacatgaa tccgctgacc cggctaagcg aatgagtgcc
     5161 ggcgagcagt atcgcgcagc gttcgagcgg ctgaagagca acaagcccga acgactgccg
     5221 aaggggacgc ccgtaagtca gaacaacgtt gccaaggagg ccggcagcga cccctctgca
     5281 ctgaaaaaag ctcgtttccc cctactgatc gctgagatcc aaaagtacgt ggaaggacac
     5341 gctgagcaac gtccgccatc agtgcgccaa gtcagcttat tagcccgcag aaaaaatcgt
     5401 ggacttcgag aacggatcga ggaaatcacg cagcagcgtg accacctagc cagcctactc
     5461 agtgaggccg acgccaccat tcttgagctg tacgaccgta ttgcggactt ggagcgccaa
     5521 ctgccggcct ccaatgtgct tcctcttgat ccgcgaggcc acaaaaaact ttgaaacgga
     5581 gagctcgcaa tattcgaaag aaacacagcc atgcccgacc agcccggcat gaaacgtcgg
     5641 gctagccgcc gaagagcttc ttgcgttgcg cggtccgctc ccggcgtaga ttctcgtagg
     5701 cagttcggcg tttagtcgcg tttttgatta attccaggac ctgggcgata tcgccgagca
     5761 actcctcacg cgcgggaagc ggtagttggc gctcgcctgg ggtgtcgtgg gcctcggtag
     5821 cttcgcaggc ccgcgcatac actgccagca actgctccca ctcctctgcg gggtggccaa
     5881 tgacagcacc aaatgcttct acgctcacca catcgctgaa cggctggacg gtattgttca
     5941 aaaaaacctc gcgtatggcg cgctcgacag tgcctcggag gcttgagtat cccgatgcga
     6001 tttgccgctc aagctcatca tccgggtcgc tgccgaccgg aacgttcagt gctttcgcac
     6061 gactttcgag atcggccagg cgggccttgg tgtccatcgt cgtccacgtc agcccctcgc
     6121 tcactagtcc cggcgactcg tcccaaccga tggtcttgta gctggccgag cgatcagcgc
     6181 gctgaagcgc catcgcgagc tcggtcagga acaccgcatc atgggtgaac accagcactt
     6241 ggcgggtctc agccagcgct accaaacgcc gagctatggc ccgacgatat acgtgatcca
     6301 gcgacgtaga cggatcgtcg aaaataacgg tcgaagtatg tggcagggat tcgagctcgg
     6361 cgaggaacat agccatcccc aacgcgcgct gctcgccctc tgacagcacc ttggaggctt
     6421 tcgccgtgat ttcctgcagg cgcagcgtga ccttggtcac ccccagctct gtgcgcccgc
     6481 tcaggtcggg ttgcacccgt cgcttatagc ccagggcttt caactcagca ttcatagaag
     6541 cggccagagc ctcggtcaca tgcgtcgccg ccagggacgt cagtttgcgt gacactgccg
     6601 ctgggttgag ggcggcatgg cagcggctca atgtggcatg gacctgactg tcctgaacaa
     6661 agcgctccac cgcgccaagc tggttggcga ggcgttgtcg ggcttctagc tctgccagtt
     6721 cttgggtcag cgccaagcgt agagcgggat cggcagaggt ccgcagggta ttggcgtcga
     6781 ctcggagcga agcagctttg gcggcgaaga gactatcgag gtttgcttcg ataggaagcg
     6841 gttctgactc gggggaccag tttccagttt gcagggcttg gctaacccaa gtatgccggg
     6901 cggtccagac cgatgccgct gcggtgatgg cagcgtgtag gtcgggcagt cgctcctcca
     6961 cgtcagcccg tgttggcaca tccagaacgt ttagatcgac agcctgcacc ttccctagag
     7021 cgttcatgcg cgcaagcgtg gcggcttgcg catccgccgt ggcgctgtcg gcgacaaatg
     7081 ccgcgaaacg ccgcatgcgc tccgaggcat ccgttgaata aggttgctgg cagagtacgc
     7141 agtaagcgtc cggttccagg tgcgggaagg gatgttcagg gtatgccgtc tgctgagaga
     7201 aagcctcagc ggctcggtac atcgtttgcc agagttcagc tcctgtgcct tccagcagcg
     7261 tggcggtggg tgaggacgtt accggcaact ccatggcgtt cagtgtgtct cgatcctgaa
     7321 gacgcgcttg cgccagttgc atggcgagat gcgcggtttt ttccgttgta atcagttcct
     7381 ttgcccgtgc tatggcacga tcattcaccc agcgctggac ttcctcggct cgacgctgcg
     7441 cctggtccaa gcgtgtcgcc aaacgttcca aggccagcgc ctgcggcaca ggatcgcttt
     7501 ccagtaatgt ccgcttcaga aactccagtc gccggagttc atcgtcaccg accgtcccta
     7561 atcgagcaag cacggcgcgg tccgagtccc cacctaattt ggcgatgtag cggccgactt
     7621 cggtgtcacc cttcagcggt tcgaattgcc gggtatccag agccaaggca ttgcgttcgg
     7681 tcccaatccg tgcctgtaaa tcacgctgaa gtaggaccag gcgcgtcaga tgagtgagtc
     7741 cgtagggctg aaatgcaggg gtcccttccg cgtcgatgta gtcattggca caggccgcgt
     7801 cgtagaccga gaccgaactc aaatgcaaat gggccggccc gttctggacc caacgtgcgg
     7861 tttccggagt gccatccacc aaaatggcga aatctgctga tggcagtcta gctggggttg
     7921 ccgccccaaa agcgtcgggc aggacctcca cccgatgccg agcgttgcag gcattcttga
     7981 agacgcgggc gtagccggat ttgccggcgc cgttatgacc aaagaaaatg gtcatgccct
     8041 ccggtgcgag gtcaaaggca cgaccggacg ggaagccgtt tacctggtct agccccgaga
     8101 cacccaccaa ccgcacggtt gcgccacttc cggcgcctgg tacgtcgtcc agcgtgaatg
     8161 gccgtgctcc ccccgtggtt gcgtcttccc gttcttgctc gcgaaccatt cgcagaatgg
     8221 tctcgatgtc atcttgggtt agttcggccc gggcaaatat ccggcgcagt gcttcctgct
     8281 gccagggtct gagtccgccg gcccacccaa taatctcgtc caacaatggc atatccgtct
     8341 cctttccaga tccgccgatt aaaggccgcg cccagttgga tggcaagtgg ccagcgcctt
     8401 cgaggtgctt cgccgtgttc cgtttgcctg ccttcctgac cgccacccta gtggcttgtc
     8461 cggtcgtgac gctacacggg cagaatttct gcatgctggc cagtatcaag ccgctctaaa
     8521 gtccgctacc ggaaagcgct gtttagcggt gagagacggg gaaagtgcgg aagctactac
     8581 cgacgcaagc gatgtggtga gcagtcctca ggtatgtgcg aaattgcact cctcttgacc
     8641 accaatttgg gttggcgttg accacggatt gcgttcaact tgaccagggc gtgtcactgt
     8701 cacgaccgtc agagaacggc caaaaacgga caccgccaac ccgttggaaa aaaaactgag
     8761 cgttgctttc cgttaagttt ggtagttgca agccccgttc aggaagaatt gctcgatcaa
     8821 cgccgccata cctgcgcgtg cgatacggcc gcggcgctcg gcgtctacca ggccgaagat
     8881 caaggaggag aagatttcgg taagcgccgg ggcaccgata tcgatacgga atacgcccag
     8941 tttttgcccg cggagaaaga actcgtccag cgtttccgag taaggcagcc atcggcagcc
     9001 gcctgcatct aaatcaaacg tgtccgggcg ccactggaat gagaggaata ccaacaactc
     9061 cctgtgaatc aaatggcctt cgatcagacg atgcaatgcg tccaagggcg ccgcctcaag
     9121 atcggcatcg gcaatgaccc tataaataac caccgaacca tgattcagaa gcatctcgat
     9181 caggttgtcg cgggtgccgc aaaacctgtt gagcctcgcc ttgctgaccc ccgctgcctg
     9241 ggctatttct ttgaacgtgg ctcgcgggtg gtcaacgatg gcgatcgcca gggccttcag
     9301 caatttctca tcggcagcag ttaaatccat cggtcactct ttatctatcg cgggcagatg
     9361 cgggtatttt gcctagaaca ctcatttttc tcaaagagga tactagcttt gttcacacca
     9421 aaatcaaatg agtcaatatt gacttatttg atttttgcgt ggatcatgcg cggcttcgac
     9481 tacgtactgg cttcgtgctt gggtgagata tgaacaaatt ccgcgaatgg atcacttttt
     9541 ccgtgatctc ctgtttggtc gccgtgaccc tggttggctg cgacaagccc gaagagcaac
     9601 gggaagaggc gccagcgcgt gaagtcgatg tgctcagcgt gaagaccgag cccttcacag
     9661 tgttcgccga gctaccaggg cgcatcgagc cggtgcgtgt cgccgaggtg cgcgcgcggg
     9721 tggcggggat cgtgctcaag cgcaccttcg aggaaggggc cgacgtgaag gccggtgacg
     9781 tgctgttcca gatcgaccct gcgccgttca aggcggccct gtcgcgggcg caaggtgaac
     9841 tggctcgcgc cgaggcgcag ctgttccagg ctcaggcgat ggttcgccgt tacgaaccac
     9901 tggtgaagat cgacgccgtc agccagcagg atttcgacaa cgccatggcc gctctgcaga
     9961 gcgcccaggc cgacaagcgc tcggcccagg ccaatgtcga aactgcccgc ctggacctgg
    10021 gttatgccga ggttcgcgcc cccatcgccg ggcgtatcgg tcgcgcccag gtcaccgaag
    10081 gggctctggt aggccagggc gaagccacgc tgctggcacg tatccagcaa ctcgatccgg
    10141 tgtacgccga cttcacccag cctgctgccg atgccctgcg cctgcgcgcg gcaatcgccg
    10201 agggcaaggt tgccggtgcg agcgaccagc cgctgtcgct gcgtgtcgac ggtaccgata
    10261 tcgagcgcaa gggcacgctg ctgttcaccg atatctcggt ggatcgcagc accgggcaga
    10321 tcgccctgcg aggccagttc gacaaccccg agggcgtgct gctgccgggt atgtacgtgc
    10381 gtgtgcgcac gccgcagggg ctcaaccaga acgccatcct ggtgccgcaa cgtgccgtgc
    10441 agcgttcggc tgacggccag gccagcgtga tgctgctggg cgagggcgat accgtcgagg
    10501 tgcgccaggt cactactggc gccatgcaag gctcgcgctg gcagatcagc gagggcctgc
    10561 aggccggcga caaggtgatc accagctcgc tggcggctat ccgtccgggc gccaaggtca
    10621 tcccacgcga gcaaggcgcc gccgaaaaag ctccacagtc ccaagcccag taagccggag
    10681 aaccattcat gcccctgttt ttcatccgac gccccaattt tgcctgggta gtcgccctgt
    10741 tcatctcgct aggtggcctg ctggtcattc cgttcctgcc ggtggcacag taccccaacg
    10801 tggcgccgcc gcagattacc gtgaccgcca cctatcccgg cgcctcggcg caggtgctga
    10861 ccgactcggt gaccagcgtc atcgaggaag aactcaacgg cgccaagaac ctgctgtact
    10921 tcgagtccac cagcaacgcc aacggcatag ccgagatcac cgtcaccttc cagccgggga
    10981 ccgaccccga actggcccag gtcgacgtgc agaaccgtct gaagaaggcc gaggcgcgca
    11041 tgccgcaggc cgtgctgacc ctcggcatcc agaccgagca ggccaccgcc ggctttctgc
    11101 tgatctattc gctgcgctac aaggatggcg acaagaacgc caacaccacg gcactggcgg
    11161 actacgcggt acgtaacgtc aacaacgaga ttcgccgtct gcccggtgtc ggcaagctgc
    11221 agttcttcga ctccgaagcc gccatgcgcg tgtggatcga cccgcagaaa ctggtcggtt
    11281 acggcctgtc catcgacgac gtcaacaacg ccatccgcac ccagaacgtg caggtgccgg
    11341 ccggcgcctt cggcagcacg ccgggctcca gcgagcagga gctgaccgcg acgctgaccg
    11401 tcaagggcac cctggacaac cccgaggaat tcgccgccat cgtgctgcgt gccaaccagg
    11461 acggctcgcg cctgaccctg ggcgacgtgg cacgcatcga ggtcggcagc caggactaca
    11521 acttcggctc gcgccaggac ggcaagcccg ccgttgccgc cgccgtgcag ctgtcgcccg
    11581 gtgccaacgc gatccagacc gccgaggcgg tcaagcagcg tctgaccgag ctgtcggcca
    11641 acttcccgga caacgtcgag ttctccgtgc cgtacgacac ctcgcgcttc gtcgacgtgg
    11701 ccatcgacaa ggtcatcatg accctcatcg aggccatggt gctggtgttc ctggtgatgt
    11761 tcctgttcct gcagaacgtg cgctacaccc tgatcccgtc catcgtcgtg ccggtgtgtc
    11821 tgcttggtac cctgaccttc atgtacctgc ttggcttctc ggtgaacatg atgaccatgt
    11881 tcggcatggt gctggccatc ggcatcttgg tggacgacgc catcgtggtg gtggagaacg
    11941 tcgagcggat catggccgag gaaggcctgg cgccggtgcc ggcgaccatc aaggcgatgg
    12001 ggcaggtgtc cggggcgatc atcggtatca ccctggttct gtcggcggtg ttcctgccgc
    12061 tggccttcat ggcgggttcg gtgggggtga tctaccagca gttctcgctg tcgctggcgg
    12121 tgtcgattct gttctcgggc tttctcgcgc tgaccttcac cccggcgctg tgcgccacgc
    12181 tgctcaagcc gattcctgta ggccatcacg agaagactgg cttcttcggc tggttcaacc
    12241 gcaagttcac cagcctgacc agccgctaca cgaagctcaa cgacaagctg gtgccgcgag
    12301 ccgggagggt gatgttcatc tacctgggcg tggtggtgct gatgggcttt ctctacatgc
    12361 gcctgccgga atccttcgtg ccggtggaag accagggtta catgatcgtc gacatccagc
    12421 tgccgcccgg cgccacccgt gagcgtacct cggccgctgg tggagagctg gagtcatttc
    12481 tgatggcccg cgaggccgtg cagacgacct tcctggtgct tggcttcagc ttctccggca
    12541 tgggcgagaa cgcggccatt gccttcccgc tgctcaagga ctggtccgag cgagattctt
    12601 cgcagtcgcc ggaagccgag tcggctgcgg tcaaccagca cttcgccaac ctcgatgacg
    12661 gcgcgatcat ggcggtgccg ccaccgccgg tcgaaggcct gggcaactcg ggtggtttcg
    12721 ccctgcgcct gcaggaccgc gccggccttg gccgcgatgc cctgttggca gcgcgcgatg
    12781 aagtgctggg caaggtcaac ggcaatccga agttcctcta cgccatgatg gaaggtctgg
    12841 ccgaggcgcc gcagctgcgc ctggtgatcg accgtgagca ggcgcgcacg ctgggagtca
    12901 gcttcgaagc gatcagcagc gcgctgtcca ctgcgttcgg ctcgtcggtg atcaacgact
    12961 tcgccaacgc cggccgccag cagcgcgtgg tggtacaggc cgaacaggcc gagcgcatga
    13021 caccggaaag cgtcctgcgc ctgcatgtgc ccaacgacag cggcagcctg gtaccgctga
    13081 gtgctttcgt caccacgagc tgggaagaag gcccggtgca ggtcgcgcgt tacaacggtt
    13141 acccgtcgat ccgcattgcc ggtgacgccg cgcccggcgt gagcactggc gaggcgatgc
    13201 tcgaactgga gcgcatcgct gccgagctgc ccgaaggtat cggttacgag tggaccgggc
    13261 tgtcgtatca ggagcgggtc gccagcgggc aggcgacgat gctgttcgcc ctggccatca
    13321 ccgtggtgtt cctgctgctg gtggcgctct acgagagctg ggcgatcccg ctgacggtga
    13381 tgctgatcgt gccggtcggc gcactcggcg cggtactggc ggtgactgct atcggcctgc
    13441 ccaacgacgt gtacttcaag gtcggcctga tcaccgtgat cggcctggcg gcgaagaacg
    13501 ccattctcat cgtcgagttc gccaaggacc tgtgggaaga cggctactcg ctgcgcgatg
    13561 ctgctgtcga agccgcgcgc ctgcgtttcc gcccgatcat catgacctcc atggcgttca
    13621 tgctcggcgt ggtgccgctg gccatcgcca ctggcgccgg cgctgcgagc cagcgcgcac
    13681 tgggcaccgg ggtgctgggc gggatgctca gcgcgaccat gctcggggtg atcttcgtgc
    13741 cgatcttctt cgtctgggtg ctgtcgctgc tgcgcaccaa acctcagcaa accgacaacc
    13801 atcccctgca taaagcggag taatgcgatg acctctcact tcatgctccg tcgcgctctg
    13861 ctgcccctgg ccatcgccgc cctggcgggt tgttcgctgg ccccgaccta cgagcgcccg
    13921 caggcaccgg tcgcgtcgca ctggcaagcc gccgacgcgg agggcgcccg tgcccaggcg
    13981 ctggactggc agaccttcat cgtcgatgcc gacttgcgcc gcgcggtgga tacggcgctg
    14041 agcaacaacc gcagcctgcg ccaggcgctg ctggatatcg aagctgcgcg tgcccagtac
    14101 cgcatccagc gtgctgatcg cctgccttcg atcaacgcca atgccagcgg caaccgccag
    14161 cgcctgcctg ccgatctgtc gcagaccggg cgctcggaag tgaccagcaa ctatcaggtc
    14221 ggcctcggcc tcgcggagta cgaagtcgac ctgttcggcc gcgtgcgcaa cctctccgag
    14281 gccgcgctgg agacctacct ggcgaccgag gaggcgaccc gtgccacgca gatcagcctg
    14341 gttgccgagg tcatccaggc ctacctgacc cgcgatggtg cgctacgccg catggccctg
    14401 gtcgaacaaa ccctggacag ccgcatggcc tcgctggagc tggtcagcca gcgccgtgca
    14461 gcgggggccg ccaccgccct ggattaccag gaagcggtcg gccttgccga acaggctagg
    14521 gccgagcgcg agagcaccga acgccagtta cgccaggcgg acaacgccct ggtcctgttg
    14581 ctcggcacgc cagatgccgc tcgcctgctg cccgcgacgc cccgcgacga cctgatggtg
    14641 ctgcaggaca tcgcccccgg caccagctcg gaactgatcg aacggcgccc ggacattctc
    14701 gccagcgagc accgcctcaa ggcgcgcaat gccgatatcg gtgcagctcg cgccgcgttc
    14761 tttccccgga tcagcctgac cggttcggtg ggcagctcca gtgccgagtt gtccggattg
    14821 ttcgatggcg gctcgcgggc ctggagcttt gccccgacgc tgtcgctgcc gatcttcgcc
    14881 ggtggccgca accgcgccaa cctggacctc gccgaagtgc gccaggacgc ggcggtggcc
    14941 gactacgaag gcaccatcca gaccgccttc cgcgaagtgg ccgatgccct ggccgccacc
    15001 gacaccctgc gccgcgagga ggctgcccgc caggctctgg ccggttccag cgaggctgcg
    15061 atggccctgg ctaaggcgcg ttacgagggc ggcgtggacg actacctgcg ttatcttgac
    15121 gcccagcgca gcacctttag caaccagacc acactaattc aaatcagcac ggaacggcag
    15181 attgcgctgg ttgacctgtt caggtctctg ggcggtggct ggggccaaac tgaaccgatg
    15241 gccgggatcg gcgctgagtg agcaaagcca ggagtcctgc atccgaagac cggactctgg
    15301 ctccatcacc ggtgagctac tggtcatcga cggggcaatc gtctgatcga gaataagact
    15361 gtctgacgac tggcaggcct atggattatt ggtggcagca gctaacggct ctataaagag
    15421 ctgcaaaaaa tcactgtaac gcatgattga ctgactgctt ctggccggtt tctgcctgtt
    15481 gcgtctctgc tgcccactgg ccaagtcgga tgcacgcggt ggtcagtacc aatgcaattg
    15541 actggtcaaa tgggtgcaat tgcgcaggta tggacttcaa gccccaattt cctggaaaag
    15601 aggttctttc tatggacatc cgacatcaga gattgagtag cggaatgtct gagctgaagt
    15661 catgtccatg gctgttcttc tttccttta
//
