LOCUS       Tn6296                 14494 bp    DNA     linear       29-SEP-2020
DEFINITION  Klebsiella pneumoniae.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Unclassified.
REFERENCE   1  (bases 1 to 14494)
  AUTHORS   Zhou,D.
  TITLE     Complete sequence of Tn6296
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14494)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2020) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
FEATURES             Location/Qualifiers
     source          1..14494
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
     repeat_region   1..38
                     /gene="IRL_Tn6296"
     CDS             complement(34..3000)
                     /gene="tnpA"
                     /codon_start=1
                     /product="Tn6296 transposase"
                     /translation="MPRRLILSATERDTLLALPESQDDLIRYYTFNDSDLSLIRQRRG
                     DANRLGFAVQLCLLRYPGYALGTDSELPEPVILWVAKQVQAEPASWAKYGERDVTRRE
                     HAQELRTYLQLAPFGLSDFRALVRELTELAQQTDKGLLLAGQALESLRQKRRILPALS
                     VIDRACSEAIARANRRVYRALVEPLTDSHRAKLDELLKLKAGSSITWLTWLRQAPLKP
                     NSRHMLEHIERLKTFQLVDLPEGLGRHIHQNRLLKLAREGGQMTPKDLGKFEPQRRYA
                     TLAAVVLESTATVIDELVDLHDRILVKLFSGAKHKHQQQFQKQGKAINDKVRLYSRIG
                     QALLEAKESGSDPYAAIEAVIPWDEFTESVSEAELLARPEGFDHLHLVGENFATLRRY
                     TPALLEVLELRAAPAAQGVLAAVQTLREMNADNLRKVPADAPTAFIKPRWKPLVITPE
                     GLDRKFYEICALSELKNALRSGDIWVKGSRQFRDFDDYLLPAEKFAALKREQALPLAI
                     NPNSDQYLEERLQLLDEQLATVTRLAKDNELPDAILTESGLKITPLDAAVPDRAQALI
                     DQTSQLLPRIKITELLMDVDDWTGFSRHFTHLKDGAEAKDRTLLLSAILGDAINLGLT
                     KMAESSPGLTYAKLSWLQAWHIRDETYSAALAELVNHQYRHAFAAHWGDGTTSSSDGQ
                     RFRAGGRGESTGHVNPKYGSEPGRLFYTHISDQYAPFSTRVVNVGVRDSTYVLDGLLY
                     HESDLRIEEHYTDTAGFTDHVFALMHLLGFRFAPRIRDLGETKLYVPQGVQAYPTLRP
                     LIGGTLNIKHVRAHWDDILRLASSIKQGTVTASLMLRKLGSYPRQNGLAVALRELGRI
                     ERTLFILDWLQSVELRRRVHAGLNKGEARNSLARAVFFNRLGEIRDRSFEQQRYRASG
                     LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDYVWRQSR
                     RLEDGKFRPLRMPGKP"
     CDS             complement(3004..3564)
                     /gene="tnpR"
                     /codon_start=1
                     /product="Tn6296 resolvase"
                     /translation="-
                     QGHRIGYVRVSSFDQNPERQLEQTQVSKVFTDKASGKDTQRPQLEALLSFVREGDTVV
                     VHSMDRLARNLDDLRRLVQKLTQRGVRIEFLKEGLVFTGEDSPMANLMLSVMGAFAEF
                     ERALIRERQREGIALAKQRGAYRGRKKALSDEQAATLRQRATAGEPKAQLAREFNISR
                     ETLYQYLRTDD"
     misc_recomb     3631..3750
                     /gene="res"
     repeat_region   3919..3956
                     /gene="IRR-1_Tn6296"
     CDS             4013..4573
                     /gene="truncated repB"
                     /codon_start=1
                     /product="Truncated replication protein"
                     /translation="MRHLFWRLNFLLLSGATNSAQMYHEAAALSSELDTRWSYRSKEL
                     MTLYSKAKSYEAGERVEFGGKSFAPLYTPKNDTLINLFQISQQEQEQLKTIISTDEAQ
                     KRRRERDRLRDEERRRAAGQLEREAYEANSLSRQKPWEAMGMSRAKWYRLGKPSPQQN
                     SETSPSPITNGEASAVALQAARCKAV"
     CDS             4728..5123
                     /gene="orf396"
                     /codon_start=1
                     /product="Hypothetical protein"
                     /translation="-
                     ANLPGTGSSSTGWPSSDLDARRKSTRWPTYQAPAAARPGGQVQIWTPEGNQPGGQLTR
                     HRQQLDQVAHFVRTKSGDAMRNLGGNPPRLRDFFNVERAFSCHSRPFWPIILIKKTGH
                     PPRSIPENSDDPHS"
     CDS             5107..5385
                     /gene="orf279"
                     /codon_start=1
                     /product="Hypothetical protein"
                     /translation="MIHTANRTFHQLYREWIRERREHMHNVLTWERDRYGARLVGLFY
                     RYCKVANPFPRCTLNTRINYRAHAVNLPDWPARSLELNKMWLSWREKK"
     CDS             5496..5921
                     /gene="klcA"
                     /codon_start=1
                     /product="Antirestriction protein KlcA"
                     /translation="MMQTELNPLICSLVATPRRMAAMPRYVGRFYVVFESMLYQQMKG
                     LCREYRGAYWLMWELSNGGFYMAPGRRDEMLNIEAMNYFSGQMSADAAGITACLYLYS
                     HLSFHTEGADQERFSRLYHSLRDWACEHDEKEAILAAID"
     CDS             6250..6546
                     /gene="korC"
                     /codon_start=1
                     /product="Transcriptional repressor protein KorC"
                     /translation="MIRPETLRPFAEDWQAPTADEIKEVLELIRQRKGLSKPLSGVDV
                     ADLVGLPGERGSGKGTRTFRRWVSKTNPSPIAYGAWSILAHLAGFGAIWDADRD"
     misc_feature    6551..7531
                     /gene="truncated tnpA"
                     /product="Truncated ISKpn6 transposase"
     repeat_region   7684..7699
                     /gene="IRR_ISKpn6"
     CDS             complement(7781..8662)
                     /gene="blaKPC-2"
                     /codon_start=1
                     /product="Carbapenemase KPC-2"
                     /translation="MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSI
                     GVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALV
                     PWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFR
                     LDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNH
                     RIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAV
                     IAAAARLALEGLGVNGQ"
     repeat_region   complement(8734..8736)
                     /gene="DR_Tn6376"
     repeat_region   complement(8737..8774)
                     /gene="IRR_Tn6376"
     repeat_region   complement(8937..8942)
                     /gene="DR_ISKpn27"
     CDS             complement(8938..9918)
                     /gene="tnpA"
                     /codon_start=1
                     /product="ISKpn27 transposase"
                     /translation="MTQALHSQARTTHLIREEIRNSTLPQAELARMYNVTRQTIRKWQ
                     NRESPEDKSHAPNKMYTTLTPEQELIVVELRKTLLLPTDDLLAVTREFINPAVSRAGL
                     GRCLRRHGVSDLRNLVEQEGTAPATKKTFKDYEPGFVHIDIKYLPQMPDETARRYLFV
                     AIDRATRWVFIELYADQTDGSSGDFLNKVQQACPVKIVKLLTDNGSQFTDRFTAGGKK
                     KEPSGTHVFDRLCKQLGIEHRLIPPRHPQTNGMVERFNGRISDIVNQTRFGSAAELES
                     TLRNYVKIYNHSIPQRALQHKTPVQALKEWHEKRPELFRKRVYNQPGLDI"
     repeat_region   complement(8943..8971)
                     /gene="IRR_ISKpn27"
     repeat_region   complement(9994..10022)
                     /gene="IRL_ISKpn27"
     repeat_region   complement(10023..10028)
                     /gene="DR_ISKpn27"
     CDS             complement(10041..10598)
                     /gene="tnpR"
                     /codon_start=1
                     /product="Resolvase"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTD
                     REGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGD
                     MGQMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTG
                     ATEIAHQLSIARSTVYKILEDERAS"
     misc_recomb     complement(10603..10716)
                     /gene="res"
     CDS             10761..13766
                     /gene="tnpA"
                     /codon_start=1
                     /product="Transposase"
                     /translation="MPVDFLTTEQTESYGRFTGEPDELQLARYFHLDEADKEFIGKSR
                     GDHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTR
                     REHAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILP
                     GATTLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGP
                     VTISGPAFNEAIERWKTLNDFGLHADNLSTLPAVRLKNLARYAGMTSVFNIARMSPQK
                     RMAVLVAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALA
                     SACSYLLKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHEEMVEQYGRV
                     RRFLPHLLNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISRSWKRLVIN
                     KEKHITRRGYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRS
                     LGHPTDPQEAIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPD
                     SLKRLSKMISDLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMA
                     EACNIGLEPLIRSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGG
                     GEVASADGMRFVTPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDS
                     IFVLEGLLEQETGLNPTEIMTDTAGTSELVFGLFWLLGYQFSPRLADAGASVFWRMDH
                     DANYGVLNDIARGQSDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLT
                     QAIIEVGRINKTLYLLNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYT
                     DGQEDQLGALGLVTNAVVLWNTMYMQAALDHLRAQGETLNDEDIARLSPLCHGHINML
                     GHYSFTLAELVTKGHLRPLKEASEVENVA"
     repeat_region   complement(13762..13799)
                     /gene="IRL_Tn6376"
     repeat_region   complement(13800..13802)
                     /gene="DR_Tn6376"
     misc_feature    13829..14305
                     /gene="truncated mcp"
                     /product="Truncated methyl-accepting chemotaxis protein"
     repeat_region   14457..14494
                     /gene="IRR-2_Tn6296"
ORIGIN      
        1 ggggagcccg cagaattcgg aaaaaatcgt acgctaaggt tttccgggca tccgtaaggg
       61 ccgaaacttc ccgtcttcca gtctgcggct ctgccgccag acgtaatcgc cggttaggtt
      121 gatgtgctcc cagcccagcg gcgacaggaa ttgcagcagc tcgccgtcca ccggcttgcc
      181 ggcctcgacc aacccctggg tggcgcgttc caggtacacc gtgttccaca gcacgatagc
      241 cgccgtcacc aggttgaggc cgctggcccg gtagcgctgc tgctcgaagc tccgatccct
      301 gatttcccca aggcggttga agaacaccgc cctggccagc gagttgcgcg cctcaccttt
      361 gttcaggccg gcatgcacgc ggcggcgcag ttcaacactt tgcagccagt ccaggatgaa
      421 cagcgtgcgc tcgatccggc ccagctcgcg cagggccacg gccagtccgt tctggcgcgg
      481 gtagctgccg agcttgcgca gcatcagcga ggcggtgacg gtgccctgct tgatcgagct
      541 ggccaggcgc aggatgtcgt cccagtgggc acgcacgtgc ttgatgttca gggtgccgcc
      601 gatcagcggg cgcaacgtcg ggtaggcttg cacgccctgc ggcacgtaca gcttggtttc
      661 gccgaggtcg cggatgcgcg gcgcgaagcg gaagcctagc aggtgcatca gggcaaagac
      721 gtgatcggtg aagccggccg tgtcggtgta gtgctcctcg atccgcaggt cggactcgtg
      781 gtacagcagg ccgtcgagca cataggtgga atcgcggacg ccgacattca ccacgcgggt
      841 gctgaacggc gcgtactggt cggagatatg ggtatagaac agccgtcccg gctcgctacc
      901 gtacttcggg ttgacgtgcc cggtgctctc gccccggcca cccgcgcgga agcgctggcc
      961 atcggaggat gaggtcgtgc cgtcgcccca gtgggcggca aaggcgtggc gatactggtg
     1021 gttgaccagc tcggccaagg ccgccgaata ggtttcgtcg cggatgtgcc aggcttgcag
     1081 ccaggacagc ttggcgtagg tcaggccggg gctcgactcg gccatcttgg tcagcccgag
     1141 gttgatcgca tcaccgagga ttgcggacag cagcaacgtc ctgtctttgg cctcggcccc
     1201 gtccttcaag tgggtgaagt ggcggctgaa gcccgtccag tcgtccacgt ccatcagcag
     1261 ttcggtgatc ttgatgcgcg gcagtaactg gctggtttgg tcgatcagcg cctgcgcccg
     1321 atccggcacc gccgcatcca gcggggtgat tttcagccct gactcggtga ggatggcatc
     1381 gggcagctcg ttgtccttgg ccaggcgggt gacggtggcc aactgctcgt ccagcagctg
     1441 caaacgctct tccaggtact ggtcgctgtt cgggttgatc gccaggggca gggcctgctc
     1501 gcgcttgagt gcggcgaact tctcggccgg cagcaggtag tcgtcgaagt cgcggaactg
     1561 ccgcgagccc ttgacccaga tgtcgccgga gcgcagggcg ttcttcagct cggacagggc
     1621 gcagatttcg tagaatttcc ggtcgaggcc ttccggggtg atcaccagcg gcttccagcg
     1681 cggcttgatg aaggccgtgg gtgcatcggc cggcaccttg cgcaggttgt cggcgttcat
     1741 ctcacgcagg gtctgcacgg ctgccagcac gccttgcgcg gccggcgcgg cgcgcagttc
     1801 cagcacctcc agcaaggccg gcgtgtaacg gcgcagggtg gcgaagttct cgccgaccag
     1861 gtgcaggtgg tcgaagcctt ccggccgggc cagcagctcg gcctcgctga cgctctcggt
     1921 gaactcgtcc cagggaatca ccgcctcgat ggcggcatag gggtcgctgc cgctttcctt
     1981 cgcttccagc agcgcctggc cgatcctgga gtacaggcgc accttgtcgt tgatcgcctt
     2041 gccctgcttc tggaactgct gctgatgctt gtgcttcgcg ccgctgaaca gcttgaccag
     2101 gatgcggtca tgcagatcga ccagctcatc gatcacggtc gcggtgctct ccagcaccac
     2161 ggcggccagg gtcgcgtagc ggcgctgcgg ctcgaactta ccgaggtctt tgggcgtcat
     2221 ctgcccaccc tcgcgggcca gcttgagcag gcggttctgg tggatgtgcc ggcccaggcc
     2281 ttcgggcaag tccaccaact gaaatgtctt cagccgctcg atgtgttcca gcatgtgccg
     2341 agagttgggt ttcagcggtg cctggcgcag ccaggtcaac caggtgatgc tgctgccggc
     2401 cttgagcttc aacagctcgt ccagcttggc ccgatgcgag tccgtgagtg gttcgaccag
     2461 ggcgcggtag acccgccgat tggctcgcgc aatggcttcc gagcaggccc ggtcaatcac
     2521 gctcagcgcc ggcaggatgc gtcgtttctg ccgtaggctc tccagggcct gaccggccag
     2581 cagcaagcct ttgtcggtct gctgggccag ctcggttagc tcgcgcacca gggcgcggaa
     2641 gtcggacagg ccgaacgggg ccagttgcag gtaggtgcgc agttcctggg catgctcgcg
     2701 acgggtcacg tcgcgctcgc cgtactttgc ccagctcgcc ggctcggcct ggacttgctt
     2761 cgccacccac aggatgaccg gctcgggcag ctcgctgtcg gttcccagcg cgtaaccggg
     2821 gtagcgcagc aggcagagct gcacggcgaa gccgaggcgg ttggcgtcgc cgcgtcgctg
     2881 gcggatcagc gacaggtcgg agtcgttgaa ggtgtagtag cggatcaggt catcctggct
     2941 ttccggcagc gcaagcaggg tgtcccgctc cgtggccgag aggatcaagc gacgcggcat
     3001 gtgtcagtcg tccgtgcgga ggtactggta gagggtttcc cggctgatgt tgaactcgcg
     3061 ggcaagctgc gccttgggct cgccggccgt cgctcgctgc cgcagggtag cagcctgctc
     3121 atcggacagg gctttcttgc ggccccggta cgcgccacgc tgcttggcca aggcgatgcc
     3181 ctcacgctgc cgctcgcgga tcagggcgcg ctcgaactca gcgaaggccc ccatcaccga
     3241 cagcatcagg ttggccatcg gcgagtcctc gccagtgaac accaggccct ccttcaggaa
     3301 ctcgatgcgc acgccgcgct gagtcagctt ctgtaccaag cgacgcaggt catcgaggtt
     3361 gcgggccagc cgatccatgc tgtgcaccac cactgtatcg ccttcgcgga cgaagctcag
     3421 cagcgcttcg agctgggggc gctgggtgtc cttgcccgat gccttgtcgg tgaacacctt
     3481 gctcacctgg gtttgttcca gctggcgttc cgggttctgg tcaaagctgc tgacccggac
     3541 gtagccgatg cggtgcccct gcacgatgtc tccttggttg aaggcggctt aagtgcactt
     3601 tctgttccgt tgtgcctcaa agcccatttc tgtcaggctg aaatctataa ccttcgcggg
     3661 catgtgtcaa aaaatgggaa agcagactct attctgacga agcggcgcgg ccctgcctga
     3721 catcaagtta gggtatagcc tagattgaca tgcgcgatgc aacccttaac ttgcttgcac
     3781 ctatcgtttc catgctagct ttatcgtaac gctaaggaag ctctgaaaaa gcccatgttt
     3841 cgcgaaatca ccgctctgta acccgcatgg ttgctgggat gcatttctcg agcgggggct
     3901 ttttcagacc ttccttagct tagcgtacga ttttttccga attctgcggt tccccctgga
     3961 agacctacgc aagttgggcc agctcagagg tggaatcaac gaaggcgagc gaatgaggca
     4021 tcttttctgg cgtcttaact ttctccttct ctccggggca acaaacagcg cccagatgta
     4081 ccatgaggcc gccgctcttt cctccgagct ggatactcgt tggtcttacc gctccaaaga
     4141 gcttatgacg ctctacagca aggcgaaatc ctatgaggct ggggaacgtg tcgagttcgg
     4201 cggaaagtcg tttgcaccgc tatacacgcc caaaaacgac acgctgatca acctattcca
     4261 gatctcacag caagaacaag agcaactgaa gacgattatc agcactgacg aggctcagaa
     4321 gcgccgcaga gagcgcgata gactgcgtga tgaagaacgt cgccgcgccg ctggccagct
     4381 tgagcgtgaa gcctatgaag ccaactcatt gagcaggcaa aagccctggg aagctatggg
     4441 catgagccgg gctaaatggt atcgcctggg caagccttca cctcaacaaa acagtgagac
     4501 aagtccctcc cctattacta atggcgaagc ctcagcggtt gcccttcagg cggccaggtg
     4561 taaagccgtt tagatggcta tttcaaagtg agtgagattt cgtaacggat ggcagcccta
     4621 gaggctgctt tcttttgagg ggttagcagg cgtatagcca tgctggatct cagtctatca
     4681 ctacctgctt aatattccac ctttagatcc ggcagcagtt cgaccaggtg gccaacttac
     4741 caggcaccgg cagcagctcg accgggtggc caagttcaga tctggacgcc agaaggaaat
     4801 caaccaggtg gccaacttac caggcaccgg cagcagctcg accaggtggc caagttcaga
     4861 tctggacgcc agaaggaaat caaccaggtg gccaactcac caggcatcgg cagcagctcg
     4921 accaggtggc ccatttcgta cgtacgaaat caggcgacgc tatgcgaaat cttggcggca
     4981 atcccccgcg actacgtgat ttttttaacg tagagcgcgc tttttcttgc catagtaggc
     5041 cattttggcc tataatctta attaagaaga ccgggcaccc gccacggtca ataccggaga
     5101 actccgatga tccacacagc taaccgcacc tttcaccaac tctatcgaga atggatacgc
     5161 gaacgccgcg agcatatgca caacgttttg acctgggagc gtgatcgtta cggtgctcgc
     5221 ctcgtcggtc tgttttatcg ttactgcaag gtggccaacc cctttccccg ttgcactctg
     5281 aatactcgga tcaactaccg cgcccatgcg gtgaatctgc cagattggcc agcccgcagc
     5341 ctggagctga ataaaatgtg gctcagttgg agagaaaaaa agtaggccga tttggcctat
     5401 tttttattgt acccgcttga cacaataggc caaaatggcc tattatatat ctcagaaggc
     5461 cgggcacccg ccacggtcaa taccggagaa ctccgatgat gcaaacagaa cttaatcccc
     5521 tgatctgctc cctggtcgcc acccctcgcc gtatggctgc aatgccccgc tatgtaggcc
     5581 gtttctatgt ggttttcgag tcgatgcttt accagcaaat gaaagggctc tgccgcgagt
     5641 atcgcggggc ttattggctt atgtgggagc tgtcgaacgg cggcttttat atggctcctg
     5701 ggcgtcgtga tgaaatgctg aacatcgagg ccatgaacta ctttagtggc caaatgagcg
     5761 ccgatgctgc cgggattacc gcttgcctct acctctatag ccatctgtca tttcacacag
     5821 aaggcgctga ccaggagcgg ttttcaaggc tgtatcacag cttgcgggat tgggcttgtg
     5881 agcatgacga aaaagaggcc atcttggccg caatagacta gcaacagaaa gccccggtga
     5941 tggccggggc tcttaaagga ggtgcatagg tagaaaaaga aatggtgccc ctggtatggc
     6001 tgcaaccaat cacaggggct ttcaccggtc aatttgagga taaacgcgat gaatacggat
     6061 attgtatcac ttgcaaaaca cattggcgac gctctgacgg cccgccgccc cgttcatatg
     6121 ccgcgcatga agatgcggga gcttggcttg ctcttgattg aactgaaggc gtatcgggag
     6181 gccgccgcga ccgttaccca ttgataaaaa agccccggca ttgaccgggg ctatttgagg
     6241 atttatcgca tgattagacc tgaaacgctt aggccgttcg ctgaagattg gcaggctcca
     6301 accgccgatg aaatcaaaga ggtgttggag ctgattaggc aacgaaaagg gcttagtaag
     6361 cctctcagtg gcgttgatgt cgctgatctc gttggtttgc ctggtgagag aggcagcgga
     6421 aagggaaccc gaaccttcag gcgttgggtg agcaaaacca accctagccc tattgcttat
     6481 ggtgcctggt ctatcttggc ccacctggca ggtttcgggg ctatatggga cgctgaccgg
     6541 gattgaaacc atgaccgaac ataaggccga acgtgctccc tggggagact tcccggcagt
     6601 agtgaggaac ggcgatctaa aggatctctc taaagaacct gaatacgaag ccgccaaaca
     6661 tggcgaccac aaggcgatga gctataagcg catgaagccg gccgaggacg aattgcattg
     6721 cgagatcaag gcgctgcttg atcgcgccaa ggctaccgac gaccaggagc gtaacgagcc
     6781 ggagctggac attcctgccg agatttctcg ccgcgagaag cgcctggagg cgatccaggc
     6841 ggcaaaggcg cgcctggaag cgcgccagcg tgaagcggac caggcccggg ggcgcagcga
     6901 agacgatggc cgccggcctc gccatccgga tggctcggac aagggcggtg gctcgtacaa
     6961 acgcgagttt ggtgtgccgg atgaccgtga tcaggaaagc ttcaccgatc cggacagccg
     7021 gatcatgaaa cacgccggtg gtggctccga gcagagctac aacgggtaca cagcggtcga
     7081 tgccgagcac cagatcatcg tggcggcgga gttgaccaac tgcgccgcgg acagtcaggc
     7141 gctgctgggc atgctggcag cagttcaggc caacaccgga gaaatgccgg cccagacgct
     7201 ggcggatgcg ggattccgta gtgaggctgt tctggcaaag gtcgccgatc accacggcga
     7261 tgtcatcgtt gccctcggcc gcgagggacg tgaagatgcc aaggtcaatg ccaagaccca
     7321 tccgcatacg gcggcgattg cggcgaaatt gaaaacggag caaggcgatg cagcttaccg
     7381 ccggcgcaag tcgatcgtgg aggctccgaa tggttggatc aaggcggtga tgggattgcg
     7441 tcagttcagc atgaggggcc tggacaaggt gcaagccgag tggaagctcg tctgcatggc
     7501 gctaaatctg aggcgaatgg cgtatctgtg agggcgaagg ttaaatgggg cggctcaaat
     7561 gcaccccagt cgtcataaca cgccgcgcgc cgcaagattg gtatccttgg cgccgacgcc
     7621 ttgccaattg cagagagcgc cgccgccatc gtcagtgctc tacagaaaac cggtcacacg
     7681 gctctgccgc gcagactcct agcctaaatg tgacagtggt tggtaatcca tgccgcccgc
     7741 aagggcggcg gtggtgggcc aatagatgat tttcagagcc ttactgcccg ttgacgccca
     7801 atccctcgag cgcgagtcta gccgcagcgg cgatgacggc ctcgctgtgc ttgtcatcct
     7861 tgttaggcgc ccgggtgtag acggccaaca caataggtgc gcgcccagtg ggccagacga
     7921 cggcatagtc atttgccgtg ccatacactc cgcaggttcc ggttttgtct ccgactgccc
     7981 agtctgccgg caccgccgcg cggatgcggt ggttgccggt cgtgtttccc tttagccaat
     8041 caacaaactg ctgccgctgc ggcgcagcca gtgcagagcc cagtgtcagt ttttgtaagc
     8101 tttccgtcac ggcgcgcggc gatgaggtat cgcgcgcatc gcctgggatg gcggagttca
     8161 gctccagctc ccagcggtcc agacggaacg tggtatcgcc gatagagcgc atgaaggccg
     8221 tcagcccggc cgggccgccc aactccttca gcaacaaatt ggcggcggcg ttatcactgt
     8281 attgcacggc ggccgcggac agctccgcca ccgtcatgcc tgttgtcaga tatttttccg
     8341 agatgggtga ccacggaacc agcgcatttt tgccgtaacg gatgggtgtg tccagcaagc
     8401 cggcctgctg ctggctgcga gccagcacag cggcagcaag aaagcccttg aatgagctgc
     8461 acagtgggaa gcgctcctca gcgcggtaac ttacagttgc gcctgagccg gtatccatcg
     8521 cgtacacacc gatggagccg ccaaagtcct gttcgagttt agcgaatggt tccgcgacga
     8581 ggttggtcag cgcggtggca gaaaagccag ccagcggcca tgagagacaa gacagcagaa
     8641 ctagacggcg atacagtgac atcaacgata ttccttgttt gaaggtggag ctaggtgtag
     8701 cggccggatg taatcaggcc gctacagctg ggattagggg tctgacgctc agtggaacga
     8761 aaactcacgt taagaagtca tttttcaata ttattgaagc atttatcagg gttattgtct
     8821 catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac
     8881 atttccccga aaagtgccac ctgacgtcta agaaaccatt attatcatga cattaaccta
     8941 tatgtcaaga cccggctggt tatacacgcg tttcctgaac aattcagggc gtttttcatg
     9001 ccattccttg agcgcctgaa cgggtgtttt gtgttggagc gcgcgttgcg gaatgctgtg
     9061 gttgtagatc ttgacgtaat tgcgcagcgt cgattccagt tcggcagctg aaccaaaacg
     9121 ggtctggttg acgatgtcgc tgatacgacc gttgaagcgc tccaccatgc cgttggtctg
     9181 cggatgacga ggcgggatga gccggtgctc gatgccgagc tgcttgcaca ggcggtcgaa
     9241 cacgtgtgtg ccgctgggtt ccttcttctt gccgccagcc gtgaagcggt cggtgaactg
     9301 gctgccgttg tcggtcagaa gcttgacgat cttgacggga caggcttgct ggactttgtt
     9361 gaggaagtcg ccactgctgc catcggtctg gtcggcatag agctcgatga agacccagcg
     9421 cgtagcacgg tcgatggcaa cgaagagata gcgccttgcc gtctcgtcgg gcatctgcgg
     9481 caggtacttg atgtcgatgt gcacaaagcc cggctcgtag tccttgaagg tctttttcgt
     9541 ggcgggcgca gtgccttcct gctcgaccag gttacgtaga tccgagacac cgtggcggcg
     9601 caggcaacgt cccaggccgg cacgcgagac ggctggattg atgaactcgc gcgtgaccgc
     9661 cagcaggtcg tccgtgggca gcagcaacgt cttgcgcagc tccaccacga tgagctcctg
     9721 ctcgggcgtg agcgtcgtgt acatcttgtt cggcgcatgc gacttgtctt caggagactc
     9781 gcggttttgc cactttcgga tggtttggcg ggtgacgttg tacatcctgg ccagttcggc
     9841 ctgcgggagc gtcgagttcc tgatttcctc acggatcagg tgggtagtac gggcttggct
     9901 gtgcagtgcc tgggtcatcg agttgccagt gaagagtcgg attggaacag tgtacgcaaa
     9961 acgtgtctgg ccttgaagag cggccagcta cgcatgggta catgatccca cgagtccaga
    10021 cacctataaa aataggcgta tcacgaggcc ctttcgtctt caagaatttt ataaaccgtg
    10081 gagcgggcaa tactgagctg atgagcaatt tccgttgcac cagtgccctt ctgatgaagc
    10141 gtcagcacga cgttcctgtc cacggtacgc ctgcggccaa atttgattcc tttcagcttt
    10201 gcttcctgtc ggccctcatt cgtgcgctct aggatcctcc ggcgttcagc ttgtgccaca
    10261 gccgacagga tggtgaccac catttgcccc atatcaccgt cggtactgat cccgtcgtca
    10321 ataaaccgaa ccgcgacacc ctgagcatca aactctttta tcagttggat catgtcggcg
    10381 gtgtcgcggc caagacggtc gagcttcttc accagaatga catcaccttc ctccaccttc
    10441 atcctcagca aatccagccc ttcccgatct gttgaactgc cggatgcctt gtcggtaaag
    10501 atgcggttag cttttacccc tgcatctttg agcgctctga tctgaatatc gagggactgc
    10561 tggctggttg agacccgcgc ataaccaaaa attcgcataa aatgtacctt aaatcgaata
    10621 tcagacacga tgtgtctatt atgccaaaat gacgatttaa tggacactca aacgaagccg
    10681 ttttactatg tctgataatt tataacattt cggacggttg caaaaatgtt actaaatgcc
    10741 cgtcaggcag ggaggccgat atgcccgttg actttctgac cactgagcag actgaaagct
    10801 atggcagatt caccggtgaa ccggatgagc ttcagctggc acgatatttt catcttgatg
    10861 aagcagacaa ggaatttatc ggaaaaagca gaggtgatca caaccgtctg ggcattgccc
    10921 tgcaaattgg atgtgtccgt tttctgggca ccttcctcac cgatatgaat catattcctt
    10981 ccggcgtccg gcattttacc gccagacagc tcgggattcg tgatatcacc gttcttgcag
    11041 aatacggtca gagggaaaat acccgccgtg agcatgcagc gctgatacgt cagcactatc
    11101 agtatcgtga atttgcctgg ccctggacat ttcgccttac ccgtctttta tatacccgga
    11161 gctggataag caacgaacgt cctggcctgc ttttcgatct ggcgacaggg tggcttatgc
    11221 aacatcgtat tattctcccc ggagccacta cgctgacccg gttgatttca gaggtaaggg
    11281 aaaaggcgac gttgcgcctg tggaacaaac tggcactgat accgtcagcc gaacaacgtt
    11341 cacagctgga gatgctgctg gggccaactg attgcagccg cctgtcttta ctggaatcac
    11401 tgaaaaaagg ccctgtgacc atcagtggcc cggcgtttaa tgaagcaatt gaacgctgga
    11461 aaactctgaa cgattttggc ttgcatgctg acaacctgag tacactcccg gctgtgcgcc
    11521 tgaaaaatct cgcacgttat gctggtatga cttcggtgtt caatattgcc aggatgtcac
    11581 cgcagaaaag gatggcggtt ctggttgcct ttgtccttgc atgggaaacg ctggcgttgg
    11641 atgatgcact ggacgttctg gacgccatgc tggccgttat catccgtgac gccagaaaga
    11701 ttgggcagaa aaaacggctc cgctcgctga aggatctgga taaatctgca ttggcgctcg
    11761 ccagcgcatg ttcgtacctg ctgaaagaag aaacaccgga cgaatcgatt cgtgctgagg
    11821 tgttcagcta catccccagg caaaagctgg ctgaaatcat cacgcttgtc cgtgaaattg
    11881 cccggccctc agacgataat tttcatgaag aaatggtgga gcagtacggg cgcgttcgtc
    11941 gtttcctgcc ccatctgctg aataccgtta aattttcatc cgcacctgcc ggggttacca
    12001 ctctgaatgc ctgtgactac ctcagccggg agttcagctc acggcggcag ttttttgacg
    12061 acgcaccaac ggaaattatc agtcggtcat ggaaacggct ggtgattaac aaggaaaaac
    12121 atatcacccg caggggatac acgctctgct ttctcagtaa actgcaggat agtctgaggc
    12181 ggagggatgt ctacgttacc ggcagtaacc ggtggggaga tccccgagca agattactac
    12241 agggtgctga ctggcaggca aaccggatta aggtttatcg ttctctggga cacccgacag
    12301 acccgcagga agcaataaaa tctctgggtc atcagcttga tagtcgttac agacaggttg
    12361 ctgcacgtct tggcgaaaat gaggctgtcg aactcgatgt ttctggcccg aagccccggt
    12421 tgacaatttc tcccctcgcc agtcttgatg agccggacag tctgaaacga ctgagcaaaa
    12481 tgatcagtga tctgctccct ccggtggatt taacggagtt gctgctcgaa attaacgccc
    12541 ataccggatt tgctgatgag tttttccatg ctagtgaagc cagtgccaga gttgatgatc
    12601 tgcccgtcag catcagcgcc gtgctgatgg ctgaagcctg caatatcggt ctggaaccac
    12661 tgatcagatc aaatgttcct gcactgaccc gacaccggct gaactggaca aaagcgaact
    12721 atctgcgggc tgaaactatc accagcgcta atgccagact ggttgatttt caggcaacgc
    12781 tgccactggc acagatatgg ggtggcggag aagtggcatc tgcagatgga atgcgctttg
    12841 ttacgccagt cagaacaatc aatgccggac cgaaccgcaa atactttggt aataacagag
    12901 ggatcacctg gtacaacttt gtgtccgatc agtattccgg ctttcatggc atcgttatac
    12961 cggggacgct gagggactct atctttgtgc tggaaggcct tctggaacag gagaccgggc
    13021 tgaatccaac cgaaattatg accgatacag caggtaccag cgaacttgtc tttggccttt
    13081 tctggctgct gggataccag ttttctccac gcctggctga tgccggtgct tcggttttct
    13141 ggcgaatgga ccatgatgcc aactatggcg tgctgaatga tattgccaga gggcaatcag
    13201 atccccgaaa aatagtcctt cagtgggacg aaatgatccg gaccgctggc tccctgaaac
    13261 tgggcaaagt acaggcttca gtgctggtcc gttcattgct gaaaagtgaa cgtccttccg
    13321 gactgactca ggcaatcatt gaagtggggc gcatcaacaa aacgctgtat ctgcttaatt
    13381 atattgatga tgaagattac cgccggcgca ttctgaccca gcttaatcgg ggagaaagcc
    13441 gccatgccgt tgccagagcc atctgtcacg gtcaaaaagg tgagataaga aaacgatata
    13501 ccgacggtca ggaagatcaa ctgggcgcac tggggctggt cactaacgcc gtcgtgttat
    13561 ggaacactat gtatatgcag gcagccctgg atcatctccg ggcgcaaggt gaaacactga
    13621 atgatgaaga tatcgcacgc ctctccccgc tttgccacgg acatatcaat atgctcggcc
    13681 attattcctt cacgctggca gaactggtga ccaaaggaca tctgagacca ttaaaagagg
    13741 cgtcagaggt agaaaacgtt gcttaacgtg agttttcgtt ccactgagcg tcagacccct
    13801 tatacgaggg atcgccgagc aaacgaattt gttggcactc aacgcagcaa ttgaggccgc
    13861 gcgtgctggt gagcaggggc gtggttttgc tgttgtcgcc gatgaggttc gcagtcttgc
    13921 tgctcgcaca cagcaatcga caacggatat tcaaagcatg atcagcgctc tacaagagcg
    13981 agcgcaatcc gctgttacag tcatggagca aagtagtcgg caagcgcaca cgagtgtagc
    14041 tcacgcagag gaagcagcta cagctcttga tggaattggc caacgcgtta acgaaattac
    14101 cgacatgaac gcgcaaatag cgactgcggt cgagcagcag ggagcagtaa gtgaagacat
    14161 aaaccgcagt attatcaata tacgcgatgc tgctgatacc aatgtacaga ccgggcagaa
    14221 taatttgcaa agtgcgaaat ctgtcgctca gttaactagc gctctgagcg aactggcaaa
    14281 acagttttgg gaaaaacgag gataacgctt ttcagtatct cgacagggat aacttacttt
    14341 accatcggtt atccctttta gccgcacaaa ttttagccat ggcttttcag gaagtcaggg
    14401 ctatcagaat ggccttagaa agcctagtca aagagctgtc acgagaacac cgttagctta
    14461 gcgtacgatt ttttccgaat tctgcggttc cccc
//
