LOCUS       In2-16                 15818 bp    DNA     linear       22-OCT-2020
DEFINITION  Providencia sp. 1709051003.
ACCESSION
VERSION
KEYWORDS    .
SOURCE      Providencia sp. 1709051003.
  ORGANISM  Providencia sp. 1709051003.
            Unclassified.
REFERENCE   1  (bases 1 to 15818)
  AUTHORS   Zhou,D.
  TITLE     Complete sequence of In2-16
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 15818)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: newbler v. 2.6
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..15818
                     /organism="Providencia sp. 1709051003."
                     /mol_type="genomic DNA"
     mobile_element  1..15818
                     /gene="In2-16"
                     /product="Class 1/2 integron: In2-16"
     misc_feature    complement(1..978)
                     /gene="intI2"
                     /product="Integrase"
     regulatory      1085..1112
                     /gene="Pc2A"
                     /product="Promoter Pc2A"
     regulatory      1085..1090
                     /gene="-35 region_Pc2A"
                     /product="-35 region of Pc2A"
     misc_recomb     1100..1162
                     /gene="attI2"
                     /product="attI2 site"
     regulatory      1107..1112
                     /gene="-10 region_Pc2A"
                     /product="-10 region of Pc2A"
     regulatory      1193..1220
                     /gene="Pc2B"
                     /product="Promoter Pc2B"
     regulatory      1193..1198
                     /gene="-35 region_Pc2B"
                     /product="-35 region of Pc2B"
     regulatory      1215..1220
                     /gene="-10 region_Pc2B"
                     /product="-10 region of Pc2B"
     CDS             1364..2209
                     /gene="lnu(F)"
                     /codon_start=1
                     /transl_table=11
                     /product="Lincosamide nucleotidyltransferase"
                     /translation="MLQQKMIERFKEACHEDARIIAALMFGSFAIGEGDEFSDIEFAV
                     FIQDDHFENFDQRSWLNAVSPVAAYFPDDFGHHTALFENGIRGEFHFMRKSDIPVIST
                     WQGYGWFPSLEEAVLLDRSGELSRYASALVGSPPKREGAPLVEGLVLNLISLMLFGAN
                     LLNRGEYARAWALLSKAHENLLKLVRLHEGATDHWPTPSRALEKDVSEDSYNRYLACT
                     GSAEPKALCVAYHETWKWSLELFRSVAGPLNIELPRIVIAQTKRLLNESATPHNKMLT
                     SEEEL"
     misc_recomb     2039..2044
                     /gene="truncated attC_lnu(F)"
                     /product="Truncated attC site for lnu(F)"
     CDS             2206..2679
                     /gene="dfrA1"
                     /codon_start=1
                     /transl_table=11
                     /product="Dihydrofolate reductase"
                     /translation="MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVG
                     RKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEI
                     YKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG"
     misc_recomb     2540..2545
                     /gene="truncated attC_dfrA1"
                     /product="Truncated attC site for dfrA1"
     CDS             2684..3487
                     /gene="aadA1a"
                     /codon_start=1
                     /transl_table=11
                     /product="Aminoglycoside 3''-nucleotidyltransferase"
                     /translation="MLNIMREAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDG
                     GLKPHSDIDLLVTVTVRLDETTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIP
                     WRYPAKRELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEELFDP
                     VPEQDLFEALNETLTLWNSPPDWAGDERNVVLTLSRIWYSAVTGKIAPKDVAADWAME
                     RLPAQYQPVILEARQAYLGQEEDRLASRADQLEEFVHYVKGEITKVVGK"
     misc_recomb     3355..3414
                     /gene="attC_aadA1a"
                     /product="attC site for aadA1a"
     CDS             3651..3998
                     /gene="qacED1"
                     /codon_start=1
                     /transl_table=11
                     /product="Quarternary ammonium coumpounds resistance
                     protein"
                     /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAF
                     YFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLAR
                     SPSWKSLRRPTPW"
     CDS             3992..4831
                     /gene="sul1"
                     /codon_start=1
                     /transl_table=11
                     /product="Dihydropteroate synthase"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDV
                     GPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLND
                     IQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSAL
                     RRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGAT
                     VGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGL
                     DHA"
     mobile_element  complement(4856..7009)
                     /gene="ISCR1"
                     /product="Insertion sequence: ISCR1"
     CDS             5236..6777
                     /gene="tnpA"
                     /codon_start=1
                     /transl_table=11
                     /product="ISCR1 Transposase"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASL
                     EAQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGAR
                     RMAESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIK
                     KAGYTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYD
                     ELNTLAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGP
                     QQGRKVFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPA
                     VSEKRLALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVF
                     APNSKHRVQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVC
                     EHCGGHVKVIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQ
                     SRLFD"
     misc_recomb     6989..7009
                     /gene="oriIS"
                     /product="ISCR1 oriIS"
     misc_feature    7008..7845
                     /gene="truncated dsbD"
                     /product="Truncated oxidoreductase superfamily protein
                     (pseudogene)"
     CDS             complement(7856..8494)
                     /gene="trpF"
                     /codon_start=1
                     /transl_table=11
                     /product="N-(5'-phosphoribosyl)anthranilate isomerase"
                     /translation="MPAKIKICGISTPEALDATIAARADYAGLVFYPASPRAVTSNVA
                     GALTSRAAGQIAMVGLFVDADDAVIADALVAAKLNALQLHGSESPERVAQLRARFGKP
                     VWKALPVASASDVARAAAYAGAADLILFDAKTPKGALPGGMGLAFDWSLLAGYRGALP
                     WGLAGGLNPTNVAEAIARTGAPLVDTSSGVESAPGVKDTDKITNFAFAVRLA"
     CDS             complement(8499..8864)
                     /gene="bleMBL"
                     /codon_start=1
                     /transl_table=11
                     /product="Bleomycin resistance protein"
                     /translation="MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQ
                     LEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLR
                     IGYLIDPDCTLVRLIQNPD"
     CDS             complement(8868..9680)
                     /gene="blaNDM-1"
                     /codon_start=1
                     /transl_table=11
                     /product="Beta-lactamase NDM-1"
                     /translation="MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQ
                     RFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQIL
                     NWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHS
                     LTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSL
                     GNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"
     repeat_region   complement(9774..9799)
                     /gene="IRR_ISAba125"
                     /product="ISAba125 inverted repeat right"
     misc_feature    complement(9781..10164)
                     /gene="truncated tnpA"
                     /product="Truncated ISAba125 transposase (pseudogene)"
     misc_feature    10165..10485
                     /gene="truncated sul1"
                     /product="Truncated dihydropteroate synthase (pseudogene)"
     mobile_element  complement(10510..12663)
                     /gene="ISCR1"
                     /product="Insertion sequence: ISCR1"
     CDS             10890..12431
                     /gene="tnpA"
                     /codon_start=1
                     /transl_table=11
                     /product="ISCR1 Transposase"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASL
                     EAQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGAR
                     RMAESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIK
                     KAGYTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYD
                     ELNTLAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGP
                     QQGRKVFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPA
                     VSEKRLALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVF
                     APNSKHRVQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVC
                     EHCGGHVKVIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQ
                     SRLFD"
     misc_recomb     12643..12663
                     /gene="oriIS"
                     /product="ISCR1 oriIS"
     misc_feature    12662..13499
                     /gene="truncated dsbD"
                     /product="Truncated oxidoreductase superfamily protein
                     (pseudogene)"
     CDS             complement(13510..14148)
                     /gene="trpF"
                     /codon_start=1
                     /transl_table=11
                     /product="N-(5'-phosphoribosyl)anthranilate isomerase"
                     /translation="MPAKIKICGISTPEALDATIAARADYAGLVFYPASPRAVTSNVA
                     GALTSRAAGQIAMVGLFVDADDAVIADALVAAKLNALQLHGSESPERVAQLRARFGKP
                     VWKALPVASASDVARAAAYAGAADLILFDAKTPKGALPGGMGLAFDWSLLAGYRGALP
                     WGLAGGLNPTNVAEAIARTGAPLVDTSSGVESAPGVKDTDKITNFAFAVRLA"
     CDS             complement(14153..14518)
                     /gene="bleMBL"
                     /codon_start=1
                     /transl_table=11
                     /product="Bleomycin resistance protein"
                     /translation="MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQ
                     LEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLR
                     IGYLIDPDCTLVRLIQNPD"
     CDS             complement(14522..15334)
                     /gene="blaNDM-1"
                     /codon_start=1
                     /transl_table=11
                     /product="Beta-lactamase NDM-1"
                     /translation="MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQ
                     RFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQIL
                     NWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHS
                     LTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSL
                     GNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"
     repeat_region   complement(15428..15453)
                     /gene="IRR_ISAba125"
                     /product="ISAba125 inverted repeat right"
     misc_feature    complement(15435..15818)
                     /gene="truncated tnpA"
                     /product="Truncated ISAba125 transposase (pseudogene)"
BASE COUNT     3672 a   4382 c   4270 g   3494 t
ORIGIN
        1 ttactgattg ataagtagca tcagtccatc cgcaggactg gtggtgccgg caaaatgctg
       61 acccaacaca tgcgtataga tttgcgtggt cttaacatcg ttatgcccta agagttcttg
      121 cacagtgcga atatcacgcc ccgcttgtaa tagatgcgta gcaaacgagt gacgaaatgt
      181 atgacaagtg acacgcttgc taacgatgcc tgctttttgt acggctgcct tcaatgcctt
      241 tcgcgcaacg gagtcatgca gatgatggcg gcataatttg ccgttatacg ggtggttgca
      301 gagcgtgctg gagggaaaga caaacatcca cgccgcttgt cgataagcag aagggtattt
      361 gtgatctaaa gcaaaaggca gcgatggccc tacgccttgt aagttgtcgt cttgctgaat
      421 aagccgcgct tgctcaatga gttattttat tgctgggatt aggcgcgtgg gcagtaggct
      481 gtttctgctt ttcccaccct taccgtcatg cacagtgatg cagccattat caaaatcaaa
      541 atctttaacc cgcaaacgca agcattcatt aatgcgcaaa cctgcaccat acagcagcgt
      601 aaaaataact tggttgcgag tatccataac ctgcaaaatg cgttgcactt catttgcaga
      661 gataacagag ggtagccgtc taggcttgct tgcagggata taatcaatat cgcccaacgg
      721 ctgttgtaaa aacctgttgt acaaaaaagc tagggcattt aaagcgattt tctgcgtgtt
      781 tatggctaca tgtctgctgt ttgctaagct ggataaaaac agcctgacct cttcactgcc
      841 catggtctga ggatgacgtt ttttgtgaaa cagaataaaa cgcttaatcc agtgcaggta
      901 agttttttca gttttcagcg cataaccttt ttgtcgcata tccgtgcgta tagaatttaa
      961 aaatggactg ttagacataa aacgctcctt gtcttgcaac tgtctgccta tacagcctat
     1021 tctagctggg atttaaaaaa gtgcctgttt tttacgccta gagatgcttg tttaccggta
     1081 gagttttaat ttaatgctaa ataaattaaa atgttatgag ttctttgggt gagataatgt
     1141 gcatcgtgca agcaggatag acggcatgca cgatttgtaa taacagagtg tcttgtattt
     1201 ttaaagaaag tctatttaat acaagtgatt atattaatta acggtaagca tcagcgggtg
     1261 acaaaacgag catgcttact aataaaatgt tgtgcgtaag aataaaacaa aagctgcgta
     1321 tacctttccg cagaatcagt ggcttcaaca aaaggatgtt tcaatgcttc agcagaaaat
     1381 gatcgaacgc ttcaaggaag cttgccatga ggatgcacga ataatcgcgg cgctgatgtt
     1441 cggctcattt gctatcggag agggtgacga gttctctgat atcgaatttg cagtgttcat
     1501 ccaggatgat cattttgaaa atttcgatca gcgctcgtgg cttaatgctg taagtccggt
     1561 tgcagcttac tttccggatg acttcggcca ccacaccgcg ctttttgaaa acggcattcg
     1621 cggtgaattc catttcatgc gaaaatcgga cataccggtc atttccactt ggcaaggcta
     1681 cgggtggttt ccctcgcttg aggaggctgt tttgttggac cgatcaggag agttgtcaag
     1741 gtacgcgagt gctctcgtgg gcagtccccc gaaacgtgaa ggcgcgccgc tggtggaagg
     1801 acttgtattg aacctcatca gcctgatgct ctttggggca aatcttttaa atcggggaga
     1861 gtatgctcgc gcctgggctt tgctcagcaa agcacatgaa aacttactca agttggttcg
     1921 cctccatgaa ggggcaacag accactggcc gacaccttca cgcgcgctcg aaaaggatgt
     1981 ctcggaggac tcgtataatc gctacctggc atgcacaggc agcgcggaac caaaagcact
     2041 atgtgtagcc tatcatgaaa cgtggaagtg gagtctcgaa ttgttcagga gtgtggctgg
     2101 acctctgaat atcgagcttc cgagaattgt aattgcgcag acaaaaaggt tgctaaatga
     2161 atctgcgacg ccgcacaata aaatgttaac ctctgaggaa gaattgtgaa actatcacta
     2221 atggtagcta tatcgaagaa tggagttatc gggaatggcc ctgatattcc atggagtgcc
     2281 aaaggtgaac agctcctgtt taaagctatt acctataacc aatggctgtt ggttggacgc
     2341 aagacttttg aatcaatggg agcattaccc aaccgaaagt atgcggtcgt aacacgttca
     2401 agttttacat ctgacaatga gaacgtattg atctttccat caattaaaga tgctttaacc
     2461 aacctaaaga aaataacgga tcatgtcatt gtttcaggtg gtggggagat atacaaaagc
     2521 ctgatcgatc aagtagatac actacatata tctacaatag acatcgagcc ggaaggtgat
     2581 gtttactttc ctgaaatccc cagcaatttt aggccagttt ttacccaaga cttcgcctct
     2641 aacataaatt atagttacca aatctggcaa aagggttaat aaaatgttaa acatcatgag
     2701 ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg
     2761 ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct
     2821 gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac
     2881 gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat
     2941 tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc
     3001 agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt
     3061 cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag
     3121 cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct
     3181 atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga
     3241 tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat
     3301 cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc
     3361 cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg
     3421 cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg
     3481 caaataatgt ctaacaattc gttcaagccg acgccgcttc gcggcgcggc ttaactcaag
     3541 cgttagatgc actaagcaca taattgctca cagccaaact atcaggtcaa gtctgctttt
     3601 attattttta agcgtgcata ataagcccta cacaaattgg gagatatatc atgaaaggct
     3661 ggctttttct tgttatcgca atagttggcg aagtaatcgc aacatccgca ttaaaatcta
     3721 gcgagggctt tactaagctt gccccttccg ccgttgtcat aatcggttat ggcatcgcat
     3781 tttattttct ttctctggtt ctgaaatcca tccctgtcgg tgttgcttat gcagtctggt
     3841 cgggactcgg cgtcgtcata attacagcca ttgcctggtt gcttcatggg caaaagcttg
     3901 atgcgtgggg ctttgtaggt atggggctca taattgctgc ctttttgctc gcccgatccc
     3961 catcgtggaa gtcgctgcgg aggccgacgc catggtgacg gtgttcggca ttctgaatct
     4021 caccgaggac tccttcttcg atgagagccg gcggctagac cccgccggcg ctgtcaccgc
     4081 ggcgatcgaa atgctgcgag tcggatcaga cgtcgtggat gtcggaccgg ccgccagcca
     4141 tccggacgcg aggcctgtat cgccggccga tgagatcaga cgtattgcgc cgctcttaga
     4201 cgccctgtcc gatcagatgc accgtgtttc aatcgacagc ttccaaccgg aaacccagcg
     4261 ctatgcgctc aagcgcggcg tgggctacct gaacgatatc caaggatttc ctgaccctgc
     4321 gctctatccc gatattgctg aggcggactg caggctggtg gttatgcact cagcgcagcg
     4381 ggatggcatc gccacccgca ccggtcacct tcgacccgaa gacgcgctcg acgagattgt
     4441 gcggttcttc gaggcgcggg tttccgcctt gcgacggagc ggggtcgctg ccgaccggct
     4501 catcctcgat ccggggatgg gatttttctt gagccccgca ccggaaacat cgctgcacgt
     4561 gctgtcgaac cttcaaaagc tgaagtcggc gttggggctt ccgctattgg tctcggtgtc
     4621 gcggaaatcc ttcttgggcg ccaccgttgg ccttcctgta aaggatctgg gtccagcgag
     4681 ccttgcggcg gaacttcacg cgatcggcaa tggcgctgac tacgtccgca cccacgcgcc
     4741 tggagatctg cgaagcgcaa tcaccttctc ggaaaccctc gcgaaatttc gcagtcgcga
     4801 cgccagagac cgagggttag atcatgccta gcattcacct tccggccgcc cgctaaatat
     4861 ctccttttgg gttgttaata aaacatccaa taagttgact gtgcgtgaaa aagaaagttt
     4921 tgtgtgatgg cgttgaagat cgcaccgtta agctcttatg tgggatggtg cagagctcga
     4981 cgactaccga taaaacgcaa ccgccgcaaa cagacaagaa aaagccccaa ctgataacag
     5041 ttggggcttc agtattgtga ttggtggagc aatagcaccc tgaacccaaa accttctcgc
     5101 tcaaccggta gtggctgata acaactcgtg agggctattg cgggttaagc atttagcgat
     5161 gtctagggcc agactggacg tctgaacgca agccgctgat actgtacata accacagtat
     5221 cagcggagga tacccatgtc gctggcaagg aacgccacgg cgagtcaatc gcccactcaa
     5281 acaaacggtt acgaacgcca ccaacccgac cagacgctgc tctaccagct ggttgagcag
     5341 cactacccag ccttcaaagc ctcactcgaa gcccaaggtc aacacctgcc tcgctacatc
     5401 caacaagaat tcaacgacct cctccaatgt ggccgtctgg agtatggttt catgcgggtt
     5461 cgctgcgagg attgtcatca cgagcgtctg gtcgccttca gctgtaaacg acgcggcttt
     5521 tgccctagct gcggtgcccg ccggatggcc gagagtgcgg cgctgctgat agacgaagtc
     5581 ttccccaagg agcccattcg ccagtgggtg ctcagctttc ctttccagct acgctttttg
     5641 ctggctcgcc atccccagct gatgggccag gtcttgagta tcgtctatcg tacactctca
     5701 actcatctga tcaaaaaagc cggttacacc aaagcctctg cacaaactgg ctcagtgact
     5761 cttatccaac gctttggctc cgcgctaaat ctcaatgtcc actaccacat gctgtttctc
     5821 gatggtgtct atgccgaaga tgactatggc aagcaacgct tccatcgtgt caaggcaccc
     5881 acttacgatg agctgaatac gctcgctcac accctcagcc atcgcatcgc tcgctgcatg
     5941 gaaaagcgtg ggattttgga gcgtgatgcc gagaatacgt ggttgacact ggaagagggc
     6001 gaagacgata cgctgactca attacatggt gcttcggtta cgtatcgcat tgccgtcggc
     6061 ccccagcaag ggcgcaaagt cttcaccctg caaaccttgc cagggcgtga ggataaagcc
     6121 gactcaagca gtcgagtagc caaccatgct ggtttctcgc tacacgccgg tgtgatggcc
     6181 gaagcgcatc agcgggataa gcttgagcgc ttgtgtcgct acattagtcg gccagcggtt
     6241 tcagaaaaac gtctggcatt aaccgccaat gggcaggtgc gttacgagct caaaactccg
     6301 taccgcaatg gcaccaccca tgtgatcttc gagccgctgg acttcatcgc caaactcgct
     6361 gcgttggtac ctaagccgcg agtcaacctc acacgcttcc acggcgtctt tgcaccgaac
     6421 agcaaacacc gagttcaagt aacacccgcc aagcggggca agaagcccga caaatcggaa
     6481 ggtctcgata ctaactggcg tgacaagagt cctgcagagc gccaccgcgc catgacctgg
     6541 atgcaacgcc tcaagcgagt cttcaatatt gatattgaag tctgcgaaca ctgcggcggt
     6601 cacgtcaaag tgattgccag catcgaagat ccgaaggtca ttgagcagat tctcaagcat
     6661 ctgaaacaga aaacagccaa ggcgaatgcc gccaagcagc gtgagctgcc accagaacga
     6721 gcgccgccac tgactcccag cctgttcgat ccatcacaga gtcgtctctt tgactgacga
     6781 ccccaaatcc aacactgctc aacactgcca acttttaaac ggggcggtgg ggcagtttgt
     6841 atctctcgag ctatcaggct agagatttta ccgccaaatc gaaccttatt agagcggttt
     6901 aggctggacc ggcagttaaa attggggctt gagcggtaaa cgagtgaggg aatttcaggt
     6961 aagatacttc ggatgaggag caaaaaggtg gtttatactt cctatacccg gcaccgcacc
     7021 tcggtcaagg ccgatgccgc cttcaccggc gcgaccatgg cgctgccgaa gggcaaggcc
     7081 taccgcgacg aattcttcgg cgacgtcgaa acctaccgca aggaattgct cggcaccctc
     7141 accggcacgc ccgcggccgg cgcgagcgcg accaccctga ccgtgaagta ccagggctgc
     7201 gccgatgccg gcgtgtgcta cccgccgcag acccgcaccc tgaaggtcgc gttgccgggc
     7261 gaagcgggcg ctggcggctt cggctgtaag gcgcgcgggc tgcatgatta tgtcgtcaag
     7321 aacggctctg ccgatcatcc caacgccgag gtgaaattcg cactgggtga tgtggtcaac
     7381 accatgatcg gctgcactaa tggtgaaacg atcatgctgt gccacgacac ctcgctgccg
     7441 cgcccctatt ctctcggctt tcgggtgcaa ggcaccgagg ggctgtggat ggacgtcaac
     7501 aagtcgatct atctggaggg caagagccca cagccgcacc gctgggagcc tgccgagggc
     7561 tggtttgcga aatacgatca cccgctatgg aaacgctacg ccgatctggc ggcaggggcc
     7621 gggcatggcg ggatggactg gttcgtgatc cacgcttttg tcgaggcgct gaaggccaag
     7681 gccccgatgc caatcgacat ttacgacgcg ctggcctgga gcgcgatcac gcctctgtcg
     7741 gaacaatcga ttgctgaggg caatcgcacg ttagattttc ccgacttcac ccgagggcag
     7801 tggcgcaccc gcaagccgat ctttgcgctg aacgacgcct attgatcgac gcgatttagg
     7861 ccaagcgcac cgcaaaggcg aaattggtaa tcttgtcggt atccttgacg cccggcgcgc
     7921 tttcgacgcc gctggaggta tcgaccagcg gcgctccggt gcgcgcaatc gcctcggcaa
     7981 cattcgtcgg atttagcccg cctgccagcc cccacggcaa ggcaccgcga tatccggcca
     8041 gcagcgacca gtcgaacgcc aaccccatgc cgccgggcag cgcgcctttg ggggtcttgg
     8101 cgtcgaacaa gatcaagtcc gccgccccgg cataggctgc ggcgcgtgcg acatcgctgg
     8161 cgctggcgac gggcagcgcc ttccacaccg gcttgccaaa ccgcgcgcgc aactgggcca
     8221 cgcgttcggg cgattccgaa ccgtgcagct gcagcgcgtt cagcttggct gccaccagtg
     8281 cgtcggcgat gacagcatca tccgcatcga cgaacaaacc gaccatggcg atctggccag
     8341 ctgcgcgcga tgtcaaagcg cccgcgacat tcgacgtaac cgcacggggc gacgctggat
     8401 agaacaccaa cccggcatag tccgcccgcg ccgcgatggt cgcatcgagc gcctcgggtg
     8461 tgctgatccc gcaaatcttg attttcgcgg gcatgcggtc agtcggggtt ctggatcagc
     8521 cgcaccagcg tgcagtcggg atcgatcagg tagccgatcc tcaggccgct cgcctccagt
     8581 tgcggagctt tgaagcgcgg ccagccggtg cttttttcct cggctcccgc cgcgttcacc
     8641 aatgccacca tggcatcgag atcatccaac cgcaggcaac agccgaacga gctcgtagct
     8701 gggtcgaggt caggataggg gaagaattcg agctgcaaac cgccgcgctg caggatcatc
     8761 cagccgcgat ccttccaact cgtcgcaaag cccagcttcg cataaaacgc ctctgtcaca
     8821 tcgaaatcgc gcgatggcag attgggggtg acgtggtcag ccatggctca gcgcagcttg
     8881 tcggccatgc gggccgtatg agtgattgcg gcgcggctat cgggggcgga atggctcatc
     8941 acgatcatgc tggccttggg gaacgccgca ccaaacgcgc gcgctgacgc ggcgtagtgc
     9001 tcagtgtcgg catcaccgag attgccgagc gacttggcct tgctgtcctt gatcaggcag
     9061 ccaccaaaag cgatgtcggt gccgtcgatc ccaacggtga tattgtcact ggtgtggccg
     9121 gggccggggt aaaatacctt gagcgggcca aagttgggcg cggttgctgg ttcgacccag
     9181 ccattggcgg cgaaagtcag gctgtgttgc gccgcaacca tcccctcttg cggggcaagc
     9241 tggttcgaca acgcattggc ataagtcgca atccccgccg catgcagcgc gtccataccg
     9301 cccatcttgt cctgatgcgc gtgagtcacc accgccagcg cgaccggcag gttgatctcc
     9361 tgcttgatcc agttgaggat ctgggcggtc tggtcatcgg tccaggcggt atcgaccacc
     9421 agcacgcggc cgccatccct gacgatcaaa ccgttggaag cgactgcccc gaaacccggc
     9481 atgtcgagat aggaagtgtg ctgccagaca ttcggtgcga gctggcggaa aaccagatcg
     9541 ccaaaccgtt ggtcgccagt ttccatttgc tggccaatcg tcgggcggat ttcaccgggc
     9601 atgcacccgc tcagcatcaa tgcagcggct aatgcggtgc tcagcttcgc gaccgggtgc
     9661 ataatattgg gcaattccat caagttttcc ttttattcag cattaaaaac cccgcaaatg
     9721 cgaggcctag taaatagatg atcttaattt ggttcactgt agcaaaaata tggggcgaat
     9781 tcaaacatga ggtgcgacag tttcaaaagc catatgataa tcaacaagct gagcaaattt
     9841 ctctaatggt gtaagccaat ctaacgcctt tctaggacga gtattcagtg acatggcaac
     9901 ttgatttaaa taatgctgat ctgcctgatt taaatcaatc cctttaggta aatattgcct
     9961 aattaaacca ttcatatttt cgcatgtgcc tttttgccag ggtgaatgtg ggtcacagaa
    10021 atatacatct atgcctaaat cttcttcgag tattttatgt tctgacatct cacgtccacg
    10081 gtcataggtc aacgttttac gcagttctgc aggtaaatat ttcagagctt cagttaaagc
    10141 cttgcgcact gattctgcct ttgcccgggg atgggatttt tcttgagccc cgcaccggaa
    10201 acatcgctgc acgtgctgtc gaaccttcaa aagctgaagt cggcgttggg gcttccgcta
    10261 ttggtctcgg tgtcgcggaa atccttcttg ggcgccaccg ttggccttcc tgtaaaggat
    10321 ctgggtccag cgagccttgc ggcggaactt cacgcgatcg gcaatggcgc tgactacgtc
    10381 cgcacccacg cgcctggaga tctgcgaagc gcaatcacct tctcggaaac cctcgcgaaa
    10441 tttcgcagtc gcgacgccag agaccgaggg ttagatcatg cctagcattc accttccggc
    10501 cgcccgctaa atatctcctt ttgggttgtt aataaaacat ccaataagtt gactgtgcgt
    10561 gaaaaagaaa gttttgtgtg atggcgttga agatcgcacc gttaagctct tatgtgggat
    10621 ggtgcagagc tcgacgacta ccgataaaac gcaaccgccg caaacagaca agaaaaagcc
    10681 ccaactgata acagttgggg cttcagtatt gtgattggtg gagcaatagc accctgaacc
    10741 caaaacctta tcgctcaacc ggtagtggct gataacaact cgtgagggct attgcgggtt
    10801 aagcatttag cgatgtctag ggccagactg gacgtctgaa cgcaagccgc tgatactgta
    10861 cataaccaca gtatcagcgg aggataccca tgtcgctggc aaggaacgcc acggcgagtc
    10921 aatcgcccac tcaaacaaac ggttacgaac gccaccaacc cgaccagacg ctgctctacc
    10981 agctggttga gcagcactac ccagccttca aagcctcact cgaagcccaa ggtcaacacc
    11041 tgcctcgcta catccaacaa gaattcaacg acctcctcca atgtggccgt ctggagtatg
    11101 gtttcatgcg ggttcgctgc gaggattgtc atcacgagcg tctggtcgcc ttcagctgta
    11161 aacgacgcgg cttttgccct agctgcggtg cccgccggat ggccgagagt gcggcgctgc
    11221 tgatagacga agtcttcccc aaggagccca ttcgccagtg ggtgctcagc tttcctttcc
    11281 agctacgctt tttgctggct cgccatcccc agctgatggg ccaggtcttg agtatcgtct
    11341 atcgtacact ctcaactcat ctgatcaaaa aagccggtta caccaaagcc tctgcacaaa
    11401 ctggctcagt gactcttatc caacgctttg gctccgcgct aaatctcaat gtccactacc
    11461 acatgctgtt tctcgatggt gtctatgccg aagatgacta tggcaagcaa cgcttccatc
    11521 gtgtcaaggc acccacttac gatgagctga atacgctcgc tcacaccctc agccatcgca
    11581 tcgctcgctg catggaaaag cgtgggattt tggagcgtga tgccgagaat acgtggttga
    11641 cactggaaga gggcgaagac gatacgctga ctcaattaca tggtgcttcg gttacgtatc
    11701 gcattgccgt cggcccccag caagggcgca aagtcttcac cctgcaaacc ttgccagggc
    11761 gtgaggataa agccgactca agcagtcgag tagccaacca tgctggtttc tcgctacacg
    11821 ccggtgtgat ggccgaagcg catcagcggg ataagcttga gcgcttgtgt cgctacatta
    11881 gtcggccagc ggtttcagaa aaacgtctgg cattaaccgc caatgggcag gtgcgttacg
    11941 agctcaaaac tccgtaccgc aatggcacca cccatgtgat cttcgagccg ctggacttca
    12001 tcgccaaact cgctgcgttg gtacctaagc cgcgagtcaa cctcacacgc ttccacggcg
    12061 tctttgcacc gaacagcaaa caccgagttc aagtaacacc cgccaagcgg ggcaagaagc
    12121 ccgacaaatc ggaaggtctc gatactaact ggcgtgacaa gagtcctgca gagcgccacc
    12181 gcgccatgac ctggatgcaa cgcctcaagc gagtcttcaa tattgatatt gaagtctgcg
    12241 aacactgcgg cggtcacgtc aaagtgattg ccagcatcga agatccgaag gtcattgagc
    12301 agattctcaa gcatctgaaa cagaaaacag ccaaggcgaa tgccgccaag cagcgtgagc
    12361 tgccaccaga acgagcgccg ccactgactc ccagcctgtt cgatccatca cagagtcgtc
    12421 tctttgactg acgaccccaa atccaacact gctcaacact gccaactttt aaacggggcg
    12481 gtggggcagt ttgtatctct cgagctatca ggctagagat tttaccgcca aatcgaacct
    12541 tattagagcg gtttaggctg gaccggcagt taaaattggg gcttgagcgg taaacgagtg
    12601 agggaatttc aggtaagata cttcggatga ggagcaaaaa ggtggtttat acttcctata
    12661 cccggcaccg cacctcggtc aaggccgatg ccgccttcac cggcgcgacc atggcgctgc
    12721 cgaagggcaa ggcctaccgc gacgaattct tcggcgacgt cgaaacctac cgcaaggaat
    12781 tgctcggcac cctcaccggc acgcccgcgg ccggcgcgag cgcgaccacc ctgaccgtga
    12841 agtaccaggg ctgcgccgat gccggcgtgt gctacccgcc gcagacccgc accctgaagg
    12901 tcgcgttgcc gggcgaagcg ggcgctggcg gcttcggctg taaggcgcgc gggctgcatg
    12961 attatgtcgt caagaacggc tctgccgatc atcccaacgc cgaggtgaaa ttcgcactgg
    13021 gtgatgtggt caacaccatg atcggctgca ctaatggtga aacgatcatg ctgtgccacg
    13081 acacctcgct gccgcgcccc tattctctcg gctttcgggt gcaaggcacc gaggggctgt
    13141 ggatggacgt caacaagtcg atctatctgg agggcaagag cccacagccg caccgctggg
    13201 agcctgccga gggctggttt gcgaaatacg atcacccgct atggaaacgc tacgccgatc
    13261 tggcggcagg ggccgggcat ggcgggatgg actggttcgt gatccacgct tttgtcgagg
    13321 cgctgaaggc caaggccccg atgccaatcg acatttacga cgcgctggcc tggagcgcga
    13381 tcacgcctct gtcggaacaa tcgattgctg agggcaatcg cacgttagat tttcccgact
    13441 tcacccgagg gcagtggcgc acccgcaagc cgatctttgc gctgaacgac gcctattgat
    13501 cgacgcgatt taggccaagc gcaccgcaaa ggcgaaattg gtaatcttgt cggtatcctt
    13561 gacgcccggc gcgctttcga cgccgctgga ggtatcgacc agcggcgctc cggtgcgcgc
    13621 aatcgcctcg gcaacattcg tcggatttag cccgcctgcc agcccccacg gcaaggcacc
    13681 gcgatatccg gccagcagcg accagtcgaa cgccaacccc atgccgccgg gcagcgcgcc
    13741 tttgggggtc ttggcgtcga acaagatcaa gtccgccgcc ccggcatagg ctgcggcgcg
    13801 tgcgacatcg ctggcgctgg cgacgggcag cgccttccac accggcttgc caaaccgcgc
    13861 gcgcaactgg gccacgcgtt cgggcgattc cgaaccgtgc agctgcagcg cgttcagctt
    13921 ggctgccacc agtgcgtcgg cgatgacagc atcatccgca tcgacgaaca aaccgaccat
    13981 ggcgatctgg ccagctgcgc gcgatgtcaa agcgcccgcg acattcgacg taaccgcacg
    14041 gggcgacgct ggatagaaca ccaacccggc atagtccgcc cgcgccgcga tggtcgcatc
    14101 gagcgcctcg ggtgtgctga tcccgcaaat cttgattttc gcgggcatgc ggtcagtcgg
    14161 ggttctggat cagccgcacc agcgtgcagt cgggatcgat caggtagccg atcctcaggc
    14221 cgctcgcctc cagttgcgga gctttgaagc gcggccagcc ggtgcttttt tcctcggctc
    14281 ccgccgcgtt caccaatgcc accatggcat cgagatcatc caaccgcagg caacagccga
    14341 acgagctcgt agctgggtcg aggtcaggat aggggaagaa ttcgagctgc aaaccgccgc
    14401 gctgcaggat catccagccg cgatccttcc aactcgtcgc aaagcccagc ttcgcataaa
    14461 acgcctctgt cacatcgaaa tcgcgcgatg gcagattggg ggtgacgtgg tcagccatgg
    14521 ctcagcgcag cttgtcggcc atgcgggccg tatgagtgat tgcggcgcgg ctatcggggg
    14581 cggaatggct catcacgatc atgctggcct tggggaacgc cgcaccaaac gcgcgcgctg
    14641 acgcggcgta gtgctcagtg tcggcatcac cgagattgcc gagcgacttg gccttgctgt
    14701 ccttgatcag gcagccacca aaagcgatgt cggtgccgtc gatcccaacg gtgatattgt
    14761 cactggtgtg gccggggccg gggtaaaata ccttgagcgg gccaaagttg ggcgcggttg
    14821 ctggttcgac ccagccattg gcggcgaaag tcaggctgtg ttgcgccgca accatcccct
    14881 cttgcggggc aagctggttc gacaacgcat tggcataagt cgcaatcccc gccgcatgca
    14941 gcgcgtccat accgcccatc ttgtcctgat gcgcgtgagt caccaccgcc agcgcgaccg
    15001 gcaggttgat ctcctgcttg atccagttga ggatctgggc ggtctggtca tcggtccagg
    15061 cggtatcgac caccagcacg cggccgccat ccctgacgat caaaccgttg gaagcgactg
    15121 ccccgaaacc cggcatgtcg agataggaag tgtgctgcca gacattcggt gcgagctggc
    15181 ggaaaaccag atcgccaaac cgttggtcgc cagtttccat ttgctggcca atcgtcgggc
    15241 ggatttcacc gggcatgcac ccgctcagca tcaatgcagc ggctaatgcg gtgctcagct
    15301 tcgcgaccgg gtgcataata ttgggcaatt ccatcaagtt ttccttttat tcagcattaa
    15361 aaaccccgca aatgcgaggc ctagtaaata gatgatctta atttggttca ctgtagcaaa
    15421 aatatggggc gaattcaaac atgaggtgcg acagtttcaa aagccatatg ataatcaaca
    15481 agctgagcaa atttctctaa tggtgtaagc caatctaacg cctttctagg acgagtattc
    15541 agtgacatgg caacttgatt taaataatgc tgatctgcct gatttaaatc aatcccttta
    15601 ggtaaatatt gcctaattaa accattcata ttttcgcatg tgcctttttg ccagggtgaa
    15661 tgtgggtcac agaaatatac atctatgcct aaatcttctt cgagtatttt atgttctgac
    15721 atctcacgtc cacggtcata ggtcaacgtt ttacgcagtt ctgcaggtaa atatttcaga
    15781 gcttcagtta aagccttgcg cactgattct gcctttgc
//
