LOCUS       In1684                 16536 bp    DNA     linear       29-SEP-2020
DEFINITION  Leclercia adecarboxylate.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Leclercia adecarboxylate
  ORGANISM  Leclercia adecarboxylate
            Unclassified.
REFERENCE   1  (bases 1 to 16536)
  AUTHORS   Zhou,D.
  TITLE     Complete sequence of In1684
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 16536)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2020) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
FEATURES             Location/Qualifiers
     source          1..16536
                     /organism="Leclercia adecarboxylate"
                     /mol_type="genomic DNA"
     repeat_region   1..25
                     /gene="IRi_In1684"
     CDS             complement(203..1216)
                     /gene="intI1"
                     /codon_start=1
                     /product="IntI1 integrase"
                     /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVHWVRAF
                     IRFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQ
                     EIGRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDF
                     DHGTIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALER
                     KYPRAGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATP
                     HTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLT
                     SER"
     misc_recomb     1297..1359
                     /gene="attI1"
     CDS             1463..2062
                     /gene="aacA4"
                     /codon_start=1
                     /product="Aminoglycoside 6'-N-acetyltransferase"
                     /translation="MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSH
                     IVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGW
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRA
                     IRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA"
     misc_recomb     2057..2128
                     /gene="attC_aacA4"
     CDS             2193..3023
                     /gene="blaOXA-1"
                     /codon_start=1
                     /product="Class D beta-lactamase OXA-1"
                     /translation="MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCF
                     LLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGM
                     EIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLT
                     EAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGA
                     GFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL
                     "
     misc_recomb     3043..3132
                     /gene="attC_blaOXA-1"
     CDS             3161..3793
                     /gene="catB3"
                     /codon_start=1
                     /product="Chloramphenicol acetyltransferase"
                     /translation="MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCA
                     RYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSAL
                     DAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVEPYAIVGGNPAKK
                     IKKRFTDEEISLLLEMEWWNWSLEKIKAAMPMLCSSNIVGLHKYWLEFAV"
     misc_recomb     3788..3847
                     /gene="attC_catB3"
     CDS             3878..4330
                     /gene="arr3"
                     /codon_start=1
                     /product="Rifampin ADP-ribosyl transferase"
                     /translation="MVKDWIPISHDNYKQVQGPFYHGTKANLAIGDLLTTGFISHFED
                     GRILKHIYFSALMEPAVWGAELAMSLSGLEGRGYIYIVEPTGPFEDDPNLTNKRFPGN
                     PTQSYRTCEPLRIVGVVEDWEGHPVELIRGMLDSLEDLKRRGLHVIED"
     misc_recomb     4337..4450
                     /gene="attC_aar3"
     misc_feature    4553..4601
                     /gene="truncated qacED1-5'"
                     /product="Truncated quaternary ammonium compound
                     resistance protein, 5' fragment (pseudogene)"
     repeat_region   4596..4600
                     /gene="DR_Tn6320"
     repeat_region   4601..4638
                     /gene="IRL_Tn6320"
     CDS             complement(4634..7639)
                     /gene="tnpA"
                     /codon_start=1
                     /product="Tn6320 transposase"
                     /translation="MPVDFLTTEQTESYGRFTGEPDELQLARYFHLDEADKEFIGKSR
                     GDHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTR
                     REHAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILP
                     GATTLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGP
                     VTISGPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQK
                     RMAVLVAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALA
                     SACSYLLKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHEEMVEQYGRV
                     RRFLPHLLNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISRSWKRLVIN
                     KEKHITRRGYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRS
                     LGHPTDPQEAIKSLGHQLDSRYRQVAARLCENEAVELDVSGPKPRLTISPLASLDEPD
                     SLKRLSKMISDLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMA
                     EACNIGLEPLIRSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGG
                     GEVASADGMRFVTPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDS
                     IFVLEGLLEQETGLNPTEIMTDTAGASELVFGLFWLLGYQFSPRLADAGASVFWRMDH
                     DADYGVLNDIARGQSDPRKIVLQWDEMIRTAGSLKLGKVQVSVLVRSLLKSERPSGLT
                     QAIIEVGRINKTLYLLNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYT
                     DGQEDQLGTLGLVTNAVVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINML
                     GHYSFTLAELVTKGHLRPLKEASEAENVA"
     misc_recomb     7684..7797
                     /gene="res"
     CDS             7803..8360
                     /gene="tnpR"
                     /codon_start=1
                     /product="Tn6320 resolvase"
                     /translation="MRLFGYARVSTSQQSLDLQVRALKDAGVKANRIFTDKASGSSTD
                     REGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGD
                     MGQMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTG
                     ATEIAHQLSIARSTVYKILEDERAS"
     CDS             8543..9403
                     /gene="blaTEM-1"
                     /codon_start=1
                     /product="Beta-lactamase TEM-1"
                     /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGY
                     IELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVE
                     YSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRL
                     DRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPL
                     LRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIA
                     EIGASLIKHW"
     repeat_region   9631..9644
                     /gene="IRR-2_ISEcp1"
     CDS             9662..10138
                     /gene="orf477"
                     /codon_start=1
                     /product="Orf477 protein"
                     /translation="MKQITMSDMQQQSAAAVQSPRLRAHRNFHPELSDSVQRLAIAME
                     PGTYVRPHRHPHTFELLLPLRGRFVVLNFDDRGTVTHRAILGETCTVLEMAAGTWHAV
                     LSLDTGGIIFEVKHGGYQPVAADDYAHWAPAEGEPGTTELMAWYAQAQVGDSTFAV"
     CDS             complement(10185..11060)
                     /gene="blaCTX-M-3"
                     /codon_start=1
                     /product="Beta-lactamase CTX-M-3"
                     /translation="MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQS
                     GGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKK
                     SDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGD
                     ETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNT
                     TGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESR
                     RDVLASAAKIVTDGL"
     repeat_region   complement(11188..11201)
                     /gene="IRR-1_ISEcp1"
     CDS             complement(11395..12657)
                     /gene="tnpA"
                     /codon_start=1
                     /product="ISEcp1 transposase"
                     /translation="MINKIDFKAKNLTSNAGLFLLLENAKSNGIFDFIENDLVFDNDS
                     TNKIKMNHIKTMLCGHFIGIDKLERLKLLQNDPLVNEFDISVKEPETVSRFLGNFNFK
                     TTQMFRDINFKVFKKLLTKSKLTSITIDIDSSVINVEGHQEGASKGYNPKKLGNRCYN
                     IQFAFCDELKAYVTGFVRSGNTYTANGAAEMIKEIVANIKSDDLEILFRMDSGYFDEK
                     IIETIESLGCKYLIKAKSYSTLTSQATNSSIVFVKGEEGRETTELYTKLVKWEKDRRF
                     VVSRVLKPEKERAQLSLLEGSEYDYFFFVTNTTLLSEKVVIYYEKRGNAENYIKEAKY
                     DMAVGHLLLKSFWANEAVFQMMMLSYNLFLLFKFDSLDSSEYRQQIKTFRLKYVFLAA
                     KIIKTARYVIMKLSENYPYKGVYEKCLV"
     repeat_region   complement(12830..12843)
                     /gene="IRL_ISEcp1"
     repeat_region   12935..12972
                     /gene="IRR_Tn6320"
     misc_feature    12973..13277
                     /gene="truncated qacED1-3'"
                     /product="Truncated quaternary ammonium compound
                     resistance protein, 3' fragment (pseudogene)"
     repeat_region   12973..12977
                     /gene="DR_Tn6320"
     CDS             13271..14110
                     /gene="sul1"
                     /codon_start=1
                     /product="Dihydropteroate synthase"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDV
                     GPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLND
                     IQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSAL
                     RRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGAT
                     VGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGL
                     DHA"
     CDS             14238..14738
                     /gene="orf5"
                     /codon_start=1
                     /product="Putative acetyltransferase"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARI
                     DRTFAETFVLRSELLVASCSDGIVGCCTLSAEDPEFWPDALKGEAAYLHKLAVRRTHA
                     GRGVSSALIEACRHAARTQGCAKLRLDCHPNLRGLYERLGFTHVDTFNPGWDPTFIAE
                     RLELEI"
     CDS             14762..15049
                     /gene="orf6"
                     /codon_start=1
                     /product="Hypothetical protein"
                     /translation="MSGWDGPVASRSLAVRPRCLGCARGCRYPPLPSSTLDNAAAVIA
                     ADARAGLFGPVRLARPSACLGEISGGRINGGASPPFVRVKAEDSSLKNIRL"
     repeat_region   complement(15061..15085)
                     /gene="IRt_In1684"
     repeat_region   15184..15197
                     /gene="IRL_IS6100"
     CDS             15245..16009
                     /gene="tnpA"
                     /codon_start=1
                     /product="IS6100 transposase"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDH
                     TTIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTID
                     FYLSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETA
                     HRQVKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQ
                     PGIRGEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
     repeat_region   16050..16063
                     /gene="IRR_IS6100"
     misc_feature    16064..16330
                     /gene="truncated tnpA"
                     /product="Truncated IS6100 transposase (pseudogene)"
     repeat_region   16371..16384
                     /gene="IRR_IS6100"
     repeat_region   16512..16536
                     /gene="IRt_In1684"
ORIGIN      
        1 tgtcgttttc agaagacggc tgcactgaac gtcagaagcc gactgcacta tagcagcgga
       61 ggggttggat ccatcaggca acgacgggct gctgccggcc atcagcggac gcagggagga
      121 ctttccgcaa ccggccgttc gatgcggcac cgatggcctt cgcgcagggg tagtgaatcc
      181 gccaggattg acttgcgctg ccctacctct cactagtgag gggcggcagc gcatcaagcg
      241 gtgagcgcac tccggcaccg ccaactttca gcacatgcgt gtaaatcatc gtcgtagaga
      301 cgtcggaatg gccgagcaga tcctgcacgg ttcgaatgtc gtaaccgctg cggagcaagg
      361 ccgtcgcgaa cgagtggcgg agggtgtgcg gtgtggcggg cttcgtgatg cctgcttgtt
      421 ctacggcacg tttgaaggcg cgctgaaagg tctggtcata catgtgatgg cgacgcacga
      481 caccgctccg tggatcggtc gaatgcgtgt gctgcgcaaa aacccagaac cacggccagg
      541 aatgcccggc gcgcggatac ttccgctcaa gggcgtcggg aagcgcaacg ccgctgcggc
      601 cctcggcctg gtccttcagc caccatgccc gtgcacgcga cagctgctcg cgcaggctgg
      661 gtgccaagct ctcgggtaac atcaaggccc gatccttgga gcccttgccc tcccgcacga
      721 tgatcgtgcc gtgatcgaaa tccagatcct tgacccgcag ttgcaaaccc tcactgatcc
      781 gcatgcccgt tccatacaga agctgggcga acaaacgatg ctcgccttcc agaaaaccga
      841 ggatgcgaac cacttcatcc ggggtcagca ccaccggcaa gcgccgcgac ggccgaggtc
      901 ttccgatctc ctgaagccag ggcagatccg tgcacagcac cttgccgtag aagaacagca
      961 aggccgccaa tgcctgacga tgcgtggaga ccgaaacctt gcgctcgttc gccagccagg
     1021 acagaaatgc ctcgacttcg ctgctgccca aggttgccgg gtgacgcaca ccgtggaaac
     1081 ggatgaaggc acgaacccag tggacataag cctgttcggt tcgtaagctg taatgcaagt
     1141 agcgtatgcg ctcacgcaac tggtccagaa ccttgaccga acgcagcggt ggtaacggcg
     1201 cagtggcggt tttcatggct tgttatgact gtttttttgt acagtctatg cctcgggcat
     1261 ccaagcagca agcgcgttac gccgtgggtc gatgtttgat gttatggagc agcaacgatg
     1321 ttacgcagca gggcagtcgc cctaaaacaa agttagatgc actaagcaca taattgctca
     1381 cagccaaact atcaggtcaa gtctgctttt attattttta agcgtgcata ataagcccta
     1441 cacaaattgg gagttagaca tcatgagcaa cgcaaaaaca aagttaggca tcacaaagta
     1501 cagcatcgtg accaacagca acgattccgt cacactgcgc ctcatgactg agcatgacct
     1561 tgcgatgctc tatgagtggc taaatcgatc tcatatcgtc gagtggtggg gcggagaaga
     1621 agcacgcccg acacttgctg acgtacagga acagtacttg ccaagcgttt tagcgcaaga
     1681 gtccgtcact ccatacattg caatgctgaa tggagagccg attgggtatg cccagtcgta
     1741 cgttgctctt ggaagcgggg acggatggtg ggaagaagaa accgatccag gagtacgcgg
     1801 aatagaccag ttactggcga atgcatcaca actgggcaaa ggcttgggaa ccaagctggt
     1861 tcgagctctg gttgagttgc tgttcaatga tcccgaggtc accaagatcc aaacggaccc
     1921 gtcgccgagc aacttgcgag cgatccgatg ctacgagaaa gcggggtttg agaggcaagg
     1981 taccgtaacc accccagatg gtccagccgt gtacatggtt caaacacgcc aggcattcga
     2041 gcgaacacgc agtgatgcct aacccttcca tcgaggggga cgtccaaggg ctggcgccct
     2101 tggccgcccc tcatgtcaaa cgttgggcga acccggagcc tcattaattg ttagccgtta
     2161 aaattaagcc ctttaccaaa ccaatactta ttatgaaaaa cacaatacat atcaacttcg
     2221 ctattttttt aataattgca aatattatct acagcagcgc cagtgcatca acagatatct
     2281 ctactgttgc atctccatta tttgaaggaa ctgaaggttg ttttttactt tacgatgcat
     2341 ccacaaacgc tgaaattgct caattcaata aagcaaagtg tgcaacgcaa atggcaccag
     2401 attcaacttt caagatcgca ttatcactta tggcatttga tgcggaaata atagatcaga
     2461 aaaccatatt caaatgggat aaaaccccca aaggaatgga gatctggaac agcaatcata
     2521 caccaaagac gtggatgcaa ttttctgttg tttgggtttc gcaagaaata acccaaaaaa
     2581 ttggattaaa taaaatcaag aattatctca aagattttga ttatggaaat caagacttct
     2641 ctggagataa agaaagaaac aacggattaa cagaagcatg gctcgaaagt agcttaaaaa
     2701 tttcaccaga agaacaaatt caattcctgc gtaaaattat taatcacaat ctcccagtta
     2761 aaaactcagc catagaaaac accatagaga acatgtatct acaagatctg gataatagta
     2821 caaaactgta tgggaaaact ggtgcaggat tcacagcaaa tagaacctta caaaacggat
     2881 ggtttgaagg gtttattata agcaaatcag gacataaata tgtttttgtg tccgcactta
     2941 caggaaactt ggggtcgaat ttaacatcaa gcataaaagc caagaaaaat gcgatcacca
     3001 ttctaaacac actaaattta taaaaaatct aatggcaaaa tcgcccaacc cttcaatcaa
     3061 gtcgggacgg ccaaaagcaa gcttttggct cccctcgctg gcgctcggcg ccccttattt
     3121 caaacgttag acggcaaagt cacagaccgc gggatctctt atgaccaact actttgatag
     3181 ccccttcaaa ggcaagctgc tttctgagca agtgaagaac cccaatatca aagttgggcg
     3241 gtacagctat tactctggct actatcatgg gcactcattc gatgactgcg cacggtatct
     3301 gtttccggac cgtgatgacg ttgataagtt gatcatcggt agtttctgct ctatcgggag
     3361 tggggcttcc tttatcatgg ctggcaatca ggggcatcgg tacgactggg catcatcttt
     3421 cccgttcttt tatatgcagg aagaacctgc attctcaagc gcactcgatg ccttccaaaa
     3481 agcaggtaat actgtcattg gcaatgacgt ttggatcggc tctgaggcaa tggtcatgcc
     3541 cggaatcaag atcgggcacg gtgcggtgat aggcagccgc tcgttggtga caaaagatgt
     3601 ggagccttac gctatcgttg gcggcaatcc cgctaagaag attaagaaac gcttcaccga
     3661 tgaggaaatt tcattgcttc tggagatgga gtggtggaat tggtcactgg agaagatcaa
     3721 agcggcaatg cccatgctgt gctcgtctaa tattgttggc ctgcacaagt attggctcga
     3781 gtttgccgtc taacaattca atcaagccga tgccgcttcg cggcacggct tatttcaggc
     3841 gttatgcagc caaatcccaa caattaaggg tcttaaaatg gtaaaagatt ggattcccat
     3901 ctctcatgat aattacaagc aggtgcaagg accgttctat catggaacca aagccaattt
     3961 ggcgattggt gacttgctaa ccacagggtt catctctcat ttcgaggacg gtcgtattct
     4021 taagcacatc tacttttcag ccttgatgga gccagcagtt tggggagctg aacttgctat
     4081 gtcactgtct ggcctcgagg gtcgcggcta catatacata gttgagccaa caggaccgtt
     4141 cgaagacgat ccgaatctta cgaacaaaag atttcccggt aatccaacac agtcctatag
     4201 aacctgcgaa cccttgagaa ttgttggcgt tgttgaagac tgggaggggc atcctgttga
     4261 attaataagg ggaatgttgg attcgttgga ggacttaaag cgccgtggtt tacacgtcat
     4321 tgaagactag tcctttgcat aacaaagcca tcaaaccgga cgccagagat tccgcgcctg
     4381 ttgcgcatgg cttcgccatt ttatgcgcaa taggcgcgcc accctgtcgc cgtttatggc
     4441 ggcgttagat gcactaagca cataattgct cacagccaaa ctatcaggtc aagtctgctt
     4501 ttattatttt taagcgtgca taataagccc tacacaaatt gggagatata tcatgaaagg
     4561 ctggcttttt cttgttatcg caatagttgg cgaagtaatc ggggtctgac gctcagtgga
     4621 acgaaaactc acgttaagca acgttttctg cctctgacgc ctcttttaat ggtctcagat
     4681 gtcctttggt caccagttct gccagcgtga aggaataatg gccgagcata ttgatatgtc
     4741 cgtggcaaag cggggagagg cgtgcgatat cttcatcatt cagtgtttca ccctgcgccc
     4801 ggagatgatc cagggctgcc tgcatataaa tagtgttcca taacacgacg gcgttagtga
     4861 ccagccccag tgtgcccagt tgatcttcct gaccgtcggt atatcgtttt cttatctcac
     4921 ctttttgacc gtgacagatg gctctggcaa cggcatggcg actttctccc cgattaagct
     4981 gggtcagaat gcgccggcgg taatcttcat catcaatata attaagcaga tacagcgttt
     5041 tgttgatgcg ccccacttca atgattgcct gagtcagtcc ggaaggacgt tcacttttca
     5101 gcaatgaacg gaccagcact gaaacctgta ctttgcccag cttcagggag ccagcggtcc
     5161 ggatcatttc gtcccactga aggactattt ttcggggatc tgattgccct ctggcaatat
     5221 cattcagcac gccatagtcg gcatcatggt ccattcgcca gaaaaccgaa gcaccggcat
     5281 cagccaggcg tggagaaaac tggtatccca gcagccagaa aaggccaaag acaagttcgc
     5341 tggcacctgc tgtatcggtc ataatttcgg ttggattcag cccggtctcc tgttccagaa
     5401 gaccttccag cacaaagata gagtccctca gcgtccccgg tataacgatg ccatgaaagc
     5461 cggaatactg atcggacaca aagttgtacc aggtgatccc tctgttatta ccaaagtatt
     5521 tgcggttcgg tccggcattg attgttctga ctggcgtaac aaagcgcatt ccatctgcag
     5581 atgccacttc tcctccaccc catatctgtg ccagtggcag cgttgcctga aaatcaacca
     5641 gtctggcatt agcgctggtg atagtttcag cccgcagata gttcgctttt gtccagttca
     5701 gccggtgtcg ggtcagtgca ggaacatttg atctgatcag tggttccaga ccgatattgc
     5761 aggcttcagc catcagcacg gcgctgatgc tgacgggcag atcatcaact ctggcactgg
     5821 cttcactagc atggaaaaac tcatcagcaa atccggtatg ggcgttaatt tcgagcagca
     5881 actccgttaa atccaccgga gggagtagat cactgatcat tttgctcagt cgtttcagac
     5941 tgtccggctc atcaagactg gcgaggggag aaattgtcaa ccggggcttc gggccagaaa
     6001 catcgagttc gacagcctca ttttcgcaaa gacgtgcagc aacctgtctg taacgactat
     6061 caagctgatg acccagagat tttattgctt cctgcgggtc tgtcgggtgc cccaaagaac
     6121 gataaacctt aatccggttt gcctgccagt cagcaccctg tagtaatctt gcacgaggat
     6181 ctccccaccg gttactgccg gtaacgtaga catccctccg cctcagacta tcctgcagtt
     6241 tactgagaaa gcagagcgtg tatcccctgc gggtgatatg tttttccttg ttaatcacca
     6301 gccgtttcca tgaccgactg ataatttccg ttggtgcgtc gtcaaaaaac tgccgccgtg
     6361 agctgaactc ccggctgagg tagtcacagg cattcagagt ggtaaccccg gcaggtgcgg
     6421 atgaaaattt aacggtattc agcagatggg gcaggaaacg acgaacgcgc ccgtactgct
     6481 ccaccatttc ttcatgaaaa ttatcgtctg agggccgggc aatttcacgg acaagcgtga
     6541 tgatttcagc cagcttttgc cttgggatgt agctgaacac ctcagcacga atcgattcgt
     6601 ccggtgtttc ttctttcagc aggtacgaac atgcgctggc gagcgccaat gcagatttat
     6661 ccagatcctt cagcgagcgg agccgttttt tctgcccaat ctttctggcg tcacggatga
     6721 taacggccag catggcgtcc agaacgtcca atgcatcatc cagcgccagc gtttcccatg
     6781 caaggacaaa ggcaaccaga accgccatcc ttttctgcgg tgacatcctg gcaatattga
     6841 acaccgaagt cataccagca taacgtgcga gatttttcag gcgcacagcc gggagtgtac
     6901 tcaggttttc agcatgcagg ccaaaatcgt tcagagtttt ccagcgttca attgcttcat
     6961 taaacgccgg accactgatg gtcacagggc cctttttcag tgattccagt aaagacaggc
     7021 ggctgcaatc agttggcccc agcagcatct ccagctgtga acgctgttcg gctgacggta
     7081 tcagtgccag tttgttccac aggcgcaacg tcgccttttc ccttacctct gaaatcaacc
     7141 gggtcagcgt agtggctccg gggagaataa tacgatgttg cataagccac cctgtcgcca
     7201 gatcgaaaag caggccagga cgttcgttgc ttatccagct ccgggtatat aaaagacggg
     7261 taaggcgaaa tgtccagggc caggcaaatt cacgatactg atagtgctga cgtatcagcg
     7321 ctgcatgctc acggcgggta ttttccctct gaccgtattc tgcaagaacg gtgatatcac
     7381 gaatcccgag ctgtctggcg gtaaaatgcc ggacgccgga aggaatatga ttcatatcgg
     7441 tgaggaaggt gcccagaaaa cggacacatc caatttgcag ggcaatgccc agacggttgt
     7501 gatcacctct gctttttccg ataaattcct tgtctgcttc atcaaggtga aaatatcgtg
     7561 ccagctgaag ctcatccggt tcaccggtga atctgccata gctttcagtc tgctcagtgg
     7621 tcagaaagtc aacgggcata tcggcctccc tgcctgacgg gcatttagta acatttttgc
     7681 aaccgtacga aatgttataa attatcggac atcgtaaaac tgttacatta atatgtctat
     7741 taaatcgtaa atttgtaata atagacatga gttgtccgat attcgattta aggtacattt
     7801 ttatgcgact ttttggttac gctcgggtct caaccagtca gcagtctctt gatcttcagg
     7861 tcagagcact caaagacgca ggtgtgaaag caaaccgtat atttaccgat aaggcatccg
     7921 gcagttcaac agaccgggaa gggctggatt tgctgaggat gaaggtggag gaaggtgatg
     7981 tcattctggt taagaagctc gaccgtcttg gccgcgacac tgccgatatg atccaactga
     8041 taaaggaatt tgacgctcag ggcgtggcag tccggttcat tgatgacggg atcagtaccg
     8101 acggtgatat ggggcaaatg gtggtcacca tcctgtcggc tgtggcacag gctgaacgcc
     8161 ggaggatcct agaacgcacg aatgagggcc gacaggaagc aaagctgaaa ggaatcaaat
     8221 ttggccgcag gcgtaccgtg gacaggaacg tcgtgctgac gcttcatcag aagggcactg
     8281 gtgcaacgga aattgctcat cagctcagta ttgcccgctc cacggtttat aaaattcttg
     8341 aagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt
     8401 ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt
     8461 tttctaaata cattcaaata tgtatccgct catgagacaa taaccctggt aaatgcttca
     8521 ataatattga aaaaggaaga gtatgagtat tcaacatttt cgtgtcgccc ttattccctt
     8581 ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga
     8641 tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa
     8701 gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct
     8761 gctatgtggt gcggtattat cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat
     8821 acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga
     8881 tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgctgc
     8941 caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat
     9001 gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa
     9061 cgacgagcgt gacaccacga tgcctgcagc aatggcaaca acgttgcgca aactattaac
     9121 tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa
     9181 agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc
     9241 tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc
     9301 ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag
     9361 acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta
     9421 ctcatactga aataattggg gggtgattac caccgtaaat ttttcccaga cggtaaaaag
     9481 aattacagac ttttatcaac taaaaaagtg gcctgaatat cagcactacc gtcaatacca
     9541 tttcagtaaa tcaggatagg gaaaaattgg caaacccagt tcttcacttg ctctgcgggt
     9601 tctgtcaccc tgacgtcata cggtaatccc ccccaattca ttaatcgaca aggtcatcct
     9661 gatgaaacaa attaccatga gcgatatgca gcaacagagc gcagcggctg tgcaatcgcc
     9721 tcggctccgc gcgcaccgta atttccatcc agaattaagc gattcggtcc aacgtctggc
     9781 tattgccatg gaacctggga cctacgtgcg cccgcaccga caccctcaca ccttcgagct
     9841 actgttgcca ttaaggggtc gtttcgtggt gctgaatttt gacgatcggg gtaccgtcac
     9901 ccatcgggcg atattggggg aaacctgtac ggtgctggag atggccgcag gaacctggca
     9961 tgccgtgctg tcgctggata ccggtggcat aatttttgaa gtaaaacacg gtggctatca
    10021 acccgtggct gccgatgact atgcgcactg ggctccagcg gaaggagaac caggaaccac
    10081 ggagcttatg gcctggtatg cgcaagcgca ggtgggcgac agcacttttg ccgtctaagg
    10141 cgataaacaa aaacggaatg agtttcccca ttccgtttcc gctattacaa accgtcggtg
    10201 acgattttag ccgccgacgc taatacatcg cgacggcttt ctgccttagg ttgaggctgg
    10261 gtgaagtaag tgaccagaat cagcggcgca cgatcttttg gccagatcac cgcgatatcg
    10321 ttggtggtgc catagtcacc gctgccggtt ttatccccca caacccagga agcaggcagt
    10381 ccagcctgaa tgctcgctgc accggtggta ttgcctttca tccatgtcac cagctgcgcc
    10441 cgttggctgt cgcccaatgc tttacccagc gtcagattcc gcagagtttg cgccattgcc
    10501 cgaggtgaag tggtatcacg cggatcgccc ggaatggcgg tgtttaacgt cggctcggta
    10561 cggtcgagac ggaacgtttc gtctcccagc tgtcgggcga acgcggtgac gctagccggg
    10621 ccgccaacgt gagcaatcag cttattcatc gccacgttat cgctgtactg tagcgcggcc
    10681 gcgctaagct cagccagtga catcgtccca ttgacgtgct tttccgcaat cggattatag
    10741 ttaacaaggt cagatttttt gatctcaact cgctgattta acagattcgg ttcgctttca
    10801 cttttcttca gcaccgcggc cgcggccatc actttactgg tgctgcacat cgcaaagcgc
    10861 tcatcagcac gataaagtat ttgcgaatta tctgctgtgt taatcaatgc cacacccagt
    10921 ctgcctcccg actgccgctc taattcggca agtttttgct gtacgtccgc cgtttgcgca
    10981 tacagcggca cacttcctaa caacagcgtg acggttgccg tcgccatcag cgtgaactgg
    11041 cgcagtgatt ttttaaccat gggattcctt attctggaag agacgaaata acaacaacat
    11101 gaatagtcaa tattttacct gaagcgagcc acaacgcgtc cgattttatg cttccgaaag
    11161 gcaaatacgg acgtcgccag aatgaaacct aaattccacg tgtgtttttt attagcttca
    11221 aaaatcacta tttcacgaag aatttagact gcttctcaca cattgtaaca ttatttacaa
    11281 ccacctttca atcatttttg ataaatcatt gatttcatct ttgctgcaat gatacttaat
    11341 aaactctgca agttatccac agagcaacac tcaattttat tgatgatatt cttattatac
    11401 cagacatttt tcatacactc ccttgtacgg atagttttcc gacaacttca tgattacata
    11461 tcttgcggtt ttgattattt ttgctgcaag aaatacatac ttcaaacgaa aggtctttat
    11521 ttgctgtctg tattctgaag agtccaagga atcaaacttg aacaacaaaa ataggttata
    11581 tgaaagcatc atcatttgaa acacggcttc attcgcccaa aatgacttta gcaagagatg
    11641 acccaccgcc atgtcgtatt tggcttcttt gatatagttt tcagcattac cacgcttttc
    11701 atagtatata actacttttt cagaaagcaa ggtagtattt gttacaaaga aaaagtagtc
    11761 gtattcggaa ccttctaaaa gtgataattg tgctctttct ttttctggtt tcagtacgcg
    11821 agatacgaca aatcttctgt ctttttccca tttaactaat tttgtataca gttctgtagt
    11881 ttctctacct tcttctcctt taacgaatac aattgatgaa ttcgttgctt gtgaggtgag
    11941 tgtagaataa cttttggctt taattaaata tttgcatcca agagattcta tcgtttcgat
    12001 aattttttca tcaaagtagc cactatccat tcgaaataaa atttctaaat cgtctgattt
    12061 gatgttagca acaatttctt tgatcatttc cgcagcaccg tttgcagtgt aagtattgcc
    12121 acttcttaca aatccggtaa catatgcttt taattcgtcg caaaatgcaa attggatatt
    12181 gtagcatcgg tttcccagtt tcttaggatt atatcctttt gacgcacctt cttgatgacc
    12241 ttctacgtta attacactac tatcaatatc aatcgtaatg gatgtcaatt tacttttagt
    12301 gagcagtttt ttaaagactt taaaattaat gtctctaaac atttgggttg tcttgaagtt
    12361 gaagtttcct agaaaccgtg acactgtttc aggttctttt acggaaatat caaactcgtt
    12421 gacgagggga tcattttgaa gtagctttag acgttctaac ttatcaatgc caatgaagtg
    12481 accgcagagc atggtcttta tatgattcat cttgatttta tttgttgagt cattatcaaa
    12541 tacgaggtca ttttcaataa aatcaaaaat cccattgctt tttgcattct caaggagcag
    12601 aaaaagacct gcatttgatg ttagattctt agctttgaaa tcaattttat taatcataat
    12661 tagaacccct ttttactact tttcttacta ttattttacc atatatcgag tcataaaagc
    12721 tgataattta acatattttt gagcactttt ctttcaccca atgggtgaaa gctgaatttc
    12781 gaaggaatgc atatttatca aggctttgat tatgcttttt gaagtactga cgtagaatct
    12841 aggtcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg
    12901 aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga
    12961 gcgtcagacc cctaatcgca acatccgcat taaaatctag cgagggcttt actaagcttg
    13021 ccccttccgc cgttgtcata atcggttatg gcatcgcatt ttattttctt tctctggttc
    13081 tgaaatccat ccctgtcggt gttgcttatg cagtctggtc gggactcggc gtcgtcataa
    13141 ttacagccat tgcctggttg cttcatgggc aaaagcttga tgcgtggggc tttgtaggta
    13201 tggggctcat aattgctgcc tttttgctcg cccgatcccc atcgtggaag tcgctgcgga
    13261 ggccgacgcc atggtgacgg tgttcggcat tctgaatctc accgaggact ccttcttcga
    13321 tgagagccgg cggctagacc ccgccggcgc tgtcaccgcg gcgatcgaaa tgctgcgagt
    13381 cggatcagac gtcgtggatg tcggaccggc cgccagccat ccggacgcga ggcctgtatc
    13441 gccggccgat gagatcagac gtattgcgcc gctcttagac gccctgtccg atcagatgca
    13501 ccgtgtttca atcgacagct tccaaccgga aacccagcgc tatgcgctca agcgcggcgt
    13561 gggctacctg aacgatatcc aaggatttcc tgaccctgcg ctctatcccg atattgctga
    13621 ggcggactgc aggctggtgg ttatgcactc agcgcagcgg gatggcatcg ccacccgcac
    13681 cggtcacctt cgacccgaag acgcgctcga cgagattgtg cggttcttcg aggcgcgggt
    13741 ttccgccttg cgacggagcg gggtcgctgc cgaccggctc atcctcgatc cggggatggg
    13801 atttttcttg agccccgcac cggaaacatc gctgcacgtg ctgtcgaacc ttcaaaagct
    13861 gaagtcggcg ttggggcttc cgctattggt ctcggtgtcg cggaaatcct tcttgggcgc
    13921 caccgttggc cttcctgtaa aggatctggg tccagcgagc cttgcggcgg aacttcacgc
    13981 gatcggcaat ggcgctgact acgtccgcac ccacgcgcct ggagatctgc gaagcgcaat
    14041 caccttctcg gaaaccctcg cgaaatttcg cagtcgcgac gccagagacc gagggttaga
    14101 tcatgcctag cattcacctt ccggccgccc gctagcggac cctggtcagg ttccgcgaag
    14161 gtgggcgcag acatgctggg ctcgtcagga tcaaactgca ctatgaggcg gcggttcata
    14221 ccgcgccagg ggagcgaatg gacagcgagg agcctccgaa cgttcgggtc gcctgctcgg
    14281 gtgatatcga cgaggttgtg cggctgatgc acgacgctgc ggcgtggatg tccgccaagg
    14341 gaacgcccgc ctgggacgtc gcgcggatcg accggacatt cgcggagacc ttcgtcctga
    14401 gatccgagct cctagtcgcg agttgcagcg acggcatcgt cggctgttgc accttgtcgg
    14461 ccgaggatcc cgagttctgg cccgacgccc tcaaggggga ggccgcatat ctgcacaagc
    14521 tcgcggtgcg acggacacat gcgggccggg gtgtcagctc cgcgctgatc gaggcttgcc
    14581 gccatgccgc gcgaacgcag gggtgcgcca agctgcggct cgactgccac ccgaacctgc
    14641 gtggcctata cgagcggctc ggattcaccc acgtcgacac tttcaatccc ggctgggatc
    14701 caaccttcat cgcagaacgc ctagaactcg aaatctaacg tccgttcggg catcgaggtc
    14761 catgtcgggg tgggacgggc ccgtggcttc aagatcactt gcagtccgac cgcgatgtct
    14821 tggttgcgcg agaggttgtc gatatcctcc acttccatca tcaaccctgg ataatgccgc
    14881 cgccgtcatc gccgccgacg cccgtgccgg gcttttcggg cctgtcaggc ttgctcggcc
    14941 ttcagcctgc ctgggcgaga tctccggcgg acggattaac ggcggagctt cgccgccttt
    15001 cgtgcgtgtg aaggccgaag atagttctct caaaaacatc cgtttatgag agataccaaa
    15061 tgtcattttc agaagacgac tgcaccagtt gattgggcgt aatggctgtt gtgcagccag
    15121 ctcctgacag ttcaatatca gaagtgatct gcaccaatct cgactatgct caatactcgt
    15181 gtgggctctg ttgcaaaaat cgtgaagctt gagcatgctt ggcggagatt ggacggacgg
    15241 aacgatgacg gatttcaagt ggcgccattt ccagggtgat gtgatcctgt gggcggtgcg
    15301 ctggtattgt cgctatccga tcagctatcg cgaccttgag gaaatgctgg cggaacgcgg
    15361 catttcggtc gaccatacga cgatctatcg ctgggtccag tgctacgccc cggagatgga
    15421 gaagcggctg cgctggttct ggcggcgtgg ctttgatccg agctggcgcc tggatgaaac
    15481 ctacgtcaag gtgcggggca agtggaccta cctgtaccgg gcagtcgaca agcggggcga
    15541 cacgatcgat ttctacctgt cgccgacccg cagcgccaag gcagcgaagc ggttcctggg
    15601 caaggccctg cgaggcctga agcactggga aaagcctgcc acgctcaata ccgacaaagc
    15661 gccgagctat ggtgcagcga tcaccgaatt gaagcgcgaa ggaaagctgg accgggagac
    15721 ggcccaccgg caggtgaagt atctcaataa cgtgatcgag gccgatcacg gaaagctcaa
    15781 gatactgatc aagccggtgc gcggtttcaa atcgatcccc acggcctatg ccacgatcaa
    15841 gggattcgaa gtcatgcgag ccctgcgcaa aggacaggct cgcccctggt gcctgcagcc
    15901 cggcatcagg ggcgaggtgc gccttgtgga gagagctttt ggcattgggc cctcggcgct
    15961 gacggaggcc atgggcatgc tcaaccacca tttcgcagca gccgcctgat cggcgcagag
    16021 cgacagccta cctctgactg ccgccaatct ttgcaacaga gccctcaata acgtgatcga
    16081 ggccgatcac ggaaagctca agatactgat caagccggtg cgcggtttca aatcgatccc
    16141 cacggcctat gccacgatca agggattcga agtcatgcga gccctgcgca aaggacaggc
    16201 tcgcccctgg tgcctgcagc ccggcatcag gggcgaggtg cgccttgtgg agagagcttt
    16261 tggcattggg ccctcggcgc tgacggaggc catgggcatg ctcaaccacc atttcgcagc
    16321 agccgcctga tcggcgcaga gcgacagcct acctctgact gccgccaatc tttgcaacag
    16381 agcctccgtc gccatgctca cctcgctttg gtgcacacga gtattgagca tagtcgagat
    16441 tggtgcagat cacttctgat attgaactgt caggagctgg ctgcacaaca gccattacgc
    16501 ccaatcaact ggtgcagtcg tcttctgaaa atgaca
//
