LOCUS       In1021                 14015 bp    DNA     linear       29-SEP-2020
DEFINITION  Klebsiella pneumoniae.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Unclassified.
REFERENCE   1  (bases 1 to 14015)
  AUTHORS   Zhou,D.
  TITLE     Complete sequence of In1021
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14015)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2020) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
FEATURES             Location/Qualifiers
     source          1..14015
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
     repeat_region   1..25
                     /gene="IRi_In1021"
     CDS             complement(203..1216)
                     /gene="intI1"
                     /codon_start=1
                     /product="Integrase"
                     /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVHWVRAF
                     IRFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQ
                     EIGRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDF
                     DHGTIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALER
                     KYPRAGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATP
                     HTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLT
                     SER"
     misc_recomb     1297..1359
                     /gene="attI1"
     CDS             1463..2062
                     /gene="aacA4cr"
                     /codon_start=1
                     /product="Aminoglycoside N(6')-acetyltransferase"
                     /translation="MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSH
                     IVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGR
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRA
                     IRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA"
     misc_recomb     2057..2128
                     /gene="attC_aacA4cr"
     CDS             2159..2611
                     /gene="arr-3"
                     /codon_start=1
                     /product="Rifampin ADP-ribosyltransferase"
                     /translation="MVKDWIPISHDNYKQVQGPFYHGTKANLAIGDLLTTGFISHFED
                     GRILKHIYFSALMEPAVWGAELAMSLSGLEGRGYIYIVEPTGPFEDDPNLTNKRFPGN
                     PTQSYRTCEPLRIVGVVEDWEGHPVELIRGMLDSLEDLKRRGLHVIED"
     misc_recomb     2618..2731
                     /gene="attC_arr-3"
     CDS             2744..3217
                     /gene="dfrA27"
                     /codon_start=1
                     /product="Dihydrofolate reductase"
                     /translation="-
                     KISLMAAKARNGVIGCGSDIPWNAKGEQLLFKAITYNQWLLVGRKTFEAMGALPNRKY
                     AVVSRSGSVATNDDVVVFPSIEAAMRELKTLTNHVVVSGGGEIYKSLIAHADTLHIST
                     IDSEPEGNVFFPEIPKEFNVVFEQEFHSNINYRYQIWQRG"
     misc_recomb     3212..3293
                     /gene="attC_dfrA27"
     CDS             3398..4243
                     /gene="aadA16"
                     /codon_start=1
                     /product="Aminoglycoside 3'-adenyltransferase"
                     /translation="MSNAVPAEISVQLSQALNVIEHHLGSTLLAVHLYGSALDGGLKP
                     CSDIDLLVTVTAQLDETVRQALFVDFLEVSASPGQSEALRALEVTIVVYGDVVPWRYP
                     ARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKARQHSLALAGSAAEDFFNSVPES
                     DLFKALADTLKLWNSQPDWAGDERNVVLTLSRIWYSAATGKIAPKDVAANWVMERLPV
                     QHQPVLLEAQQAYLGQGMDCLASRADQLTAFIYFVKHEAASLLGSTPMMSNSSFKPTP
                     LRGAA"
     misc_recomb     4198..4257
                     /gene="attC_aadA16"
     CDS             4360..4707
                     /gene="qacED1"
                     /codon_start=1
                     /product="Quaternary ammonium compound resistance protein"
                     /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAF
                     YFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLAR
                     SPSWKSLRRPTPW"
     CDS             4701..5540
                     /gene="sul1"
                     /codon_start=1
                     /product="Dihydropteroate synthase"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDV
                     GPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLND
                     IQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSAL
                     RRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGAT
                     VGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGL
                     DHA"
     CDS             5945..7486
                     /gene="tnpA"
                     /codon_start=1
                     /product="ISCR1 Transposase"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASL
                     EAQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGAR
                     RMAESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIK
                     KAGYTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYD
                     ELNTLAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGP
                     QQGRKVFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPA
                     VSEKRLALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVF
                     APNSKHRVQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVC
                     EHCGGHVKVIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQ
                     SRLFD"
     misc_recomb     7698..7718
                     /gene="oriIS"
     misc_feature    complement(7719..8158)
                     /gene="truncated trpF"
                     /product="Truncated N-(5'-phosphoribosyl)anthranilate
                     isomerase (pseudogene)"
     CDS             complement(8163..8528)
                     /gene="bleMBL"
                     /codon_start=1
                     /product="Bleomycin resistance protein"
                     /translation="MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQ
                     LEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLR
                     IGYLIDPDCTLVRLIQNPD"
     CDS             complement(8532..9344)
                     /gene="blaNDM-3"
                     /codon_start=1
                     /product="Beta-lactamase NDM-3"
                     /translation="MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQ
                     RFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTNDQTAQIL
                     NWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHS
                     LTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSL
                     GNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"
     repeat_region   complement(9438..9463)
                     /gene="IRR_ISAba125"
     misc_feature    complement(9445..9588)
                     /gene="truncated tnpA"
                     /product="Truncated ISAba125 transposase"
     misc_feature    9587..10000
                     /gene="truncated catB3"
                     /product="Truncated Chloramphenicol acetyltransferase"
     CDS             10085..10537
                     /gene="arr-3"
                     /codon_start=1
                     /product="Rifampin ADP-ribosyltransferase"
                     /translation="MVKDWIPISHDNYKQVQGPFYHGTKANLAIGDLLTTGFISHFED
                     GRILKHIYFSALMEPAVWGAELAMSLSGLEGRGYIYIVEPTGPFEDDPNLTNKRFPGN
                     PTQSYRTCEPLRIVGVVEDWEGHPVELIRGMLDSLEDLKRRGLHVIED"
     CDS             10760..11107
                     /gene="qacED1"
                     /codon_start=1
                     /product="Quaternary ammonium compound resistance protein"
                     /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAF
                     YFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLAR
                     SPSWKSLRRPTPW"
     CDS             11101..11940
                     /gene="sul1"
                     /codon_start=1
                     /product="Dihydropteroate synthase"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDV
                     GPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLND
                     IQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSAL
                     RRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGAT
                     VGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGL
                     DHA"
     misc_feature    12068..12245
                     /gene="truncated orf5"
                     /product="Truncated hypothetical protein (pseudogene)"
     repeat_region   12245..12282
                     /gene="IRL_chrA"
     CDS             12427..13632
                     /gene="chrA"
                     /codon_start=1
                     /product="Chromate transport protein"
                     /translation="MTNNPTDDSRPWSVFLIFLRLGLTSFGGPIAHLGYFRAEFVTRR
                     RWLSERSYADLVALCQFLPGPASSQVGIAVGLSRAGYSGALAAWAGFTLPSAIALILF
                     ALGISSYGDYVSQGALHGLKVVAVAVVAQAVWGMARNLCTDGLRVTIMAIATCVVLLV
                     PSAWGQVGVIAIAGIAGRLLFKPAKVVEHDPLPITVSHRAGVLWLSLFFVLLIGLPVL
                     AELMPSQTMAMVDSFYRVGSLVFGGGHVVLPLLQAEVVPSGWVNNESFLAGYGAAQAV
                     PGPLFTFAAFLGASMNTAPSGWIGGIVCLLAIFAPSFLLVVGSMPFWERLRRNTGIQA
                     ALAGINAAVVGLLLAALYQPVWTSAIFQPQDFGLALVALVALMFWKLPPWLVVLGSGA
                     AGWLLSVAL"
     CDS             13643..13948
                     /gene="orf98"
                     /codon_start=1
                     /product="PadR family transcriptional regulator"
                     /translation="MTDKDLYGGLIRLHILHHAAEEPVFGLGIIEELRRHGYEMSAGT
                     VYPMLHGLEKKGYLTSRHERTGRRERRVYDITEQGRTALADAKTKVKELFGELVEGG"
     repeat_region   13991..14015
                     /gene="IRt_In1021"
ORIGIN      
        1 tgtcgttttc agaagacggc tgcactgaac gtcagaagcc gactgcacta tagcagcgga
       61 ggggttggat ccatcaggca acgacgggct gctgccggcc atcagcggac gcagggagga
      121 ctttccgcaa ccggccgttc gatgcggcac cgatggcctt cgcgcagggg tagtgaatcc
      181 gccaggattg acttgcgctg ccctacctct cactagtgag gggcggcagc gcatcaagcg
      241 gtgagcgcac tccggcaccg ccaactttca gcacatgcgt gtaaatcatc gtcgtagaga
      301 cgtcggaatg gccgagcaga tcctgcacgg ttcgaatgtc gtaaccgctg cggagcaagg
      361 ccgtcgcgaa cgagtggcgg agggtgtgcg gtgtggcggg cttcgtgatg cctgcttgtt
      421 ctacggcacg tttgaaggcg cgctgaaagg tctggtcata catgtgatgg cgacgcacga
      481 caccgctccg tggatcggtc gaatgcgtgt gctgcgcaaa aacccagaac cacggccagg
      541 aatgcccggc gcgcggatac ttccgctcaa gggcgtcggg aagcgcaacg ccgctgcggc
      601 cctcggcctg gtccttcagc caccatgccc gtgcacgcga cagctgctcg cgcaggctgg
      661 gtgccaagct ctcgggtaac atcaaggccc gatccttgga gcccttgccc tcccgcacga
      721 tgatcgtgcc gtgatcgaaa tccagatcct tgacccgcag ttgcaaaccc tcactgatcc
      781 gcatgcccgt tccatacaga agctgggcga acaaacgatg ctcgccttcc agaaaaccga
      841 ggatgcgaac cacttcatcc ggggtcagca ccaccggcaa gcgccgcgac ggccgaggtc
      901 ttccgatctc ctgaagccag ggcagatccg tgcacagcac cttgccgtag aagaacagca
      961 aggccgccaa tgcctgacga tgcgtggaga ccgaaacctt gcgctcgttc gccagccagg
     1021 acagaaatgc ctcgacttcg ctgctgccca aggttgccgg gtgacgcaca ccgtggaaac
     1081 ggatgaaggc acgaacccag tggacataag cctgttcggt tcgtaagctg taatgcaagt
     1141 agcgtatgcg ctcacgcaac tggtccagaa ccttgaccga acgcagcggt ggtaacggcg
     1201 cagtggcggt tttcatggct tgttatgact gtttttttgt acagtctatg cctcgggcat
     1261 ccaagcagca agcgcgttac gccgtgggtc gatgtttgat gttatggagc agcaacgatg
     1321 ttacgcagca gggcagtcgc cctaaaacaa agttagatgc actaagcaca taattgctca
     1381 cagccaaact atcaggtcaa gtctgctttt attattttta agcgtgcata ataagcccta
     1441 cacaaattgg gagttagaca tcatgagcaa cgcaaaaaca aagttaggca tcacaaagta
     1501 cagcatcgtg accaacagca acgattccgt cacactgcgc ctcatgactg agcatgacct
     1561 tgcgatgctc tatgagtggc taaatcgatc tcatatcgtc gagtggtggg gcggagaaga
     1621 agcacgcccg acacttgctg acgtacagga acagtacttg ccaagcgttt tagcgcaaga
     1681 gtccgtcact ccatacattg caatgctgaa tggagagccg attgggtatg cccagtcgta
     1741 cgttgctctt ggaagcgggg acggacggtg ggaagaagaa accgatccag gagtacgcgg
     1801 aatagaccag ttactggcga atgcatcaca actgggcaaa ggcttgggaa ccaagctggt
     1861 tcgagctctg gttgagttgc tgttcaatga tcccgaggtc accaagatcc aaacggaccc
     1921 gtcgccgagc aacttgcgag cgatccgatg ctacgagaaa gcggggtttg agaggcaagg
     1981 taccgtaacc accccatatg gtccagccgt gtacatggtt caaacacgcc aggcattcga
     2041 gcgaacacgc agtgatgcct aacccttcca tcgaggggga cgtccaaggg ctggcgccct
     2101 tggccgcccc tcatgtcaaa cgttatgcag ccaaatccca acaattaagg gtcttaaaat
     2161 ggtaaaagat tggattccca tctctcatga taattacaag caggtgcaag gaccgttcta
     2221 tcatggaacc aaagccaatt tggcgattgg tgacttgcta accacagggt tcatctctca
     2281 tttcgaggac ggtcgtattc ttaagcacat ctacttttca gccttgatgg agccagcagt
     2341 ttggggagct gaacttgcta tgtcactgtc tggcctcgag ggtcgcggct acatatacat
     2401 agttgagcca acaggaccgt tcgaagacga tccgaatctt acgaacaaaa gatttcccgg
     2461 taatccaaca cagtcctata gaacctgcga acccttgaga attgttggcg ttgttgaaga
     2521 ctgggagggg catcctgttg aattaataag gggaatgttg gattcgttgg aggacttaaa
     2581 gcgccgtggt ttacacgtca ttgaagacta gtcctttgca taacaaagcc atcaaaccgg
     2641 acgccagaga ttccgcgcct gttgcgcatg gcttcgccat tttatgcgca ataggcgcgc
     2701 caccctgtcg ccgtttatgg cggcgttaac ccaaaggagt atcgtgaaaa tatcactaat
     2761 ggctgcaaaa gcaagaaatg gggttattgg ctgcggctcg gatatcccgt ggaacgctaa
     2821 aggtgagcag ctgcttttta aagcaataac ttacaatcaa tggctcttag tcggccgtaa
     2881 aacatttgag gcaatggggg ctctcccaaa tagaaagtat gcagttgtca gccgctcagg
     2941 atcggtagct actaacgatg atgtggttgt gtttccatct atagaagcag caatgaggga
     3001 gctaaagact cttacgaacc atgttgttgt ttctggtggt ggagagatct acaagagtct
     3061 gatcgcccat gccgacacgc tacatatctc gacaatagat tccgagccag agggcaatgt
     3121 tttctttccg gaaatcccca aagagttcaa tgtggtgttc gagcaggaat ttcattcaaa
     3181 tataaattat cgctatcaaa tctggcaaag gggttaacca tccaagccat cggacacatt
     3241 ttgcttcgct gcgctcaaaa cgcaaaatgt gccgctgctt agcggcgtta gatgcactaa
     3301 gcacataatt gctcacagcc aaactatcag gtcaagtctg cttttattat ttttaagcgt
     3361 gcataataag ccctacacaa attgggagtt agacatcatg agcaacgcag tgcccgccga
     3421 gatttcggta cagctatcac aggcactcaa cgtcatcgag catcatctgg gatcgacgtt
     3481 gctggccgtg catttgtacg gctctgcact cgacggtggc ctgaagccat gcagtgatat
     3541 tgatttgctg gttactgtga ctgcacagct cgatgagact gtgcggcagg ctctgttcgt
     3601 agatttcctg gaagtttccg cttctcccgg ccaaagtgaa gctctccgtg ccttggaagt
     3661 taccatcgtc gtgtacggcg atgttgttcc ttggcgttat ccagccagac gggaactgca
     3721 attcggggag tggcagcgca aggacattct tgcgggcatc ttcgagcccg cgacaaccga
     3781 tgttgatctg gctattctgc taactaaagc aaggcaacac agccttgcct tggcaggttc
     3841 ggccgcggaa gatttcttca actcagtccc ggaaagcgat ctattcaaag cactggccga
     3901 caccttgaaa ctatggaact cacaaccgga ttgggcaggc gacgagcgga atgtagtgct
     3961 tactttgtct cgcatttggt acagcgcagc aaccggcaag atcgcgccga aggatgtagc
     4021 tgccaactgg gtaatggaac gcctgcccgt ccaacatcag cccgtgctgc ttgaagccca
     4081 gcaggcttac cttggacaag ggatggattg cttggcctca cgcgctgatc agttgactgc
     4141 gttcatttac tttgtgaagc acgaagccgc cagtctgctc ggctccacgc caatgatgtc
     4201 taacagttca ttcaagccga cgccgcttcg cggcgcagct taattcaggc gttagatgca
     4261 ctaagcacat aattgctcac agccaaacta tcaggtcaag tctgctttta ttatttttaa
     4321 gcgtgcataa taagccctac acaaattggg agatatatca tgaaaggctg gctttttctt
     4381 gttatcgcaa tagttggcga agtaatcgca acatccgcat taaaatctag cgagggcttt
     4441 actaagcttg ccccttccgc cgttgtcata atcggttatg gcatcgcatt ttattttctt
     4501 tctctggttc tgaaatccat ccctgtcggt gttgcttatg cagtctggtc gggactcggc
     4561 gtcgtcataa ttacagccat tgcctggttg cttcatgggc aaaagcttga tgcgtggggc
     4621 tttgtaggta tggggctcat aattgctgcc tttttgctcg cccgatcccc atcgtggaag
     4681 tcgctgcgga ggccgacgcc atggtgacgg tgttcggcat tctgaatctc accgaggact
     4741 ccttcttcga tgagagccgg cggctagacc ccgccggcgc tgtcaccgcg gcgatcgaaa
     4801 tgctgcgagt cggatcagac gtcgtggatg tcggaccggc cgccagccat ccggacgcga
     4861 ggcctgtatc gccggccgat gagatcagac gtattgcgcc gctcttagac gccctgtccg
     4921 atcagatgca ccgtgtttca atcgacagct tccaaccgga aacccagcgc tatgcgctca
     4981 agcgcggcgt gggctacctg aacgatatcc aaggatttcc tgaccctgcg ctctatcccg
     5041 atattgctga ggcggactgc aggctggtgg ttatgcactc agcgcagcgg gatggcatcg
     5101 ccacccgcac cggtcacctt cgacccgaag acgcgctcga cgagattgtg cggttcttcg
     5161 aggcgcgggt ttccgccttg cgacggagcg gggtcgctgc cgaccggctc atcctcgatc
     5221 cggggatggg atttttcttg agccccgcac cggaaacatc gctgcacgtg ctgtcgaacc
     5281 ttcaaaagct gaagtcggcg ttggggcttc cgctattggt ctcggtgtcg cggaaatcct
     5341 tcttgggcgc caccgttggc cttcctgtaa aggatctggg tccagcgagc cttgcggcgg
     5401 aacttcacgc gatcggcaat ggcgctgact acgtccgcac ccacgcgcct ggagatctgc
     5461 gaagcgcaat caccttctcg gaaaccctcg cgaaatttcg cagtcgcgac gccagagacc
     5521 gagggttaga tcatgcctag cattcacctt ccggccgccc gctaaatatc tccttttggg
     5581 ttgttaataa aacatccaat aagttgactg tgcgtgaaaa agaaagtttt gtgtgatggc
     5641 gttgaagatc gcaccgttaa gctcttatgt gggatggtgc agagctcgac gactaccgat
     5701 aaaacgcaac cgccgcaaac agacaagaaa aagccccaac tgataacagt tggggcttca
     5761 gtattgtgat tggtggagca atagcaccct gaacccaaaa ccttctcgct caaccggtag
     5821 tggctgataa caactcgtga gggctattgc gggttaagca tttagcgatg tctagggcca
     5881 gactggacgt ctgaacgcaa gccgctgata ctgtacataa ccacagtatc agcggaggat
     5941 acccatgtcg ctggcaagga acgccacggc gagtcaatcg cccactcaaa caaacggtta
     6001 cgaacgccac caacccgacc agacgctgct ctaccagctg gttgagcagc actacccagc
     6061 cttcaaagcc tcactcgaag cccaaggtca acacctgcct cgctacatcc aacaagaatt
     6121 caacgacctc ctccaatgtg gccgtctgga gtatggtttc atgcgggttc gctgcgagga
     6181 ttgtcatcac gagcgtctgg tcgccttcag ctgtaaacga cgcggctttt gccctagctg
     6241 cggtgcccgc cggatggccg agagtgcggc gctgctgata gacgaagtct tccccaagga
     6301 gcccattcgc cagtgggtgc tcagctttcc tttccagcta cgctttttgc tggctcgcca
     6361 tccccagctg atgggccagg tcttgagtat cgtctatcgt acactctcaa ctcatctgat
     6421 caaaaaagcc ggttacacca aagcctctgc acaaactggc tcagtgactc ttatccaacg
     6481 ctttggctcc gcgctaaatc tcaatgtcca ctaccacatg ctgtttctcg atggtgtcta
     6541 tgccgaagat gactatggca agcaacgctt ccatcgtgtc aaggcaccca cttacgatga
     6601 gctgaatacg ctcgctcaca ccctcagcca tcgcatcgct cgctgcatgg aaaagcgtgg
     6661 gattttggag cgtgatgccg agaatacgtg gttgacactg gaagagggcg aagacgatac
     6721 gctgactcaa ttacatggtg cttcggttac gtatcgcatt gccgtcggcc cccagcaagg
     6781 gcgcaaagtc ttcaccctgc aaaccttgcc agggcgtgag gataaagccg actcaagcag
     6841 tcgagtagcc aaccatgctg gtttctcgct acacgccggt gtgatggccg aagcgcatca
     6901 gcgggataag cttgagcgct tgtgtcgcta cattagtcgg ccagcggttt cagaaaaacg
     6961 tctggcatta accgccaatg ggcaggtgcg ttacgagctc aaaactccgt accgcaatgg
     7021 caccacccat gtgatcttcg agccgctgga cttcatcgcc aaactcgctg cgttggtacc
     7081 taagccgcga gtcaacctca cacgcttcca cggcgtcttt gcaccgaaca gcaaacaccg
     7141 agttcaagta acacccgcca agcggggcaa gaagcccgac aaatcggaag gtctcgatac
     7201 taactggcgt gacaagagtc ctgcagagcg ccaccgcgcc atgacctgga tgcaacgcct
     7261 caagcgagtc ttcaatattg atattgaagt ctgcgaacac tgcggcggtc acgtcaaagt
     7321 gattgccagc atcgaagatc cgaaggtcat tgagcagatt ctcaagcatc tgaaacagaa
     7381 aacagccaag gcgaatgccg ccaagcagcg tgagctgcca ccagaacgag cgccgccact
     7441 gactcccagc ctgttcgatc catcacagag tcgtctcttt gactgacgac cccaaatcca
     7501 acactgctca acactgccaa cttttaaacg gggcggtggg gcagtttgta tctctcgagc
     7561 tatcaggcta gagattttac cgccaaatcg aaccttatta gagcggttta ggctggaccg
     7621 gcagttaaaa ttggggcttg agcggtaaac gagtgaggga atttcaggta agatacttcg
     7681 gatgaggagc aaaaaggtgg tttatacttc ctatacccaa cgccaacccc atgccgccgg
     7741 gcagcgcgcc tttgggggtc ttggcgtcga acaagatcaa gtccgccgcc ccggcatagg
     7801 ctgcggcgcg tgcgacatcg ctggcgctgg cgacgggcag cgccttccac accggcttgc
     7861 caaaccgcgc gcgcaactgg gccacgcgtt cgggcgattc cgaaccgtgc agctgcagcg
     7921 cgttcagctt ggctgccacc agtgcgtcgg cgatgacagc atcatccgca tcgacgaaca
     7981 aaccgaccat ggcgatctgg ccagctgcgc gcgatgtcaa agcgcccgcg acattcgacg
     8041 taaccgcacg gggcgacgct ggatagaaca ccaacccggc atagtccgcc cgcgccgcga
     8101 tggtcgcatc gagcgcctcg ggtgtgctga tcccgcaaat cttgattttc gcgggcatgc
     8161 ggtcagtcgg ggttctggat cagccgcacc agcgtgcagt cgggatcgat caggtagccg
     8221 atcctcaggc cgctcgcctc cagttgcgga gctttgaagc gcggccagcc ggtgcttttt
     8281 tcctcggctc ccgccgcgtt caccaatgcc accatggcat cgagatcatc caaccgcagg
     8341 caacagccga acgagctcgt agctgggtcg aggtcaggat aggggaagaa ttcgagctgc
     8401 aaaccgccgc gctgcaggat catccagccg cgatccttcc aactcgtcgc aaagcccagc
     8461 ttcgcataaa acgcctctgt cacatcgaaa tcgcgcgatg gcagattggg ggtgacgtgg
     8521 tcagccatgg ctcagcgcag cttgtcggcc atgcgggccg tatgagtgat tgcggcgcgg
     8581 ctatcggggg cggaatggct catcacgatc atgctggcct tggggaacgc cgcaccaaac
     8641 gcgcgcgctg acgcggcgta gtgctcagtg tcggcatcac cgagattgcc gagcgacttg
     8701 gccttgctgt ccttgatcag gcagccacca aaagcgatgt cggtgccgtc gatcccaacg
     8761 gtgatattgt cactggtgtg gccggggccg gggtaaaata ccttgagcgg gccaaagttg
     8821 ggcgcggttg ctggttcgac ccagccattg gcggcgaaag tcaggctgtg ttgcgccgca
     8881 accatcccct cttgcggggc aagctggttc gacaacgcat tggcataagt cgcaatcccc
     8941 gccgcatgca gcgcgtccat accgcccatc ttgtcctgat gcgcgtgagt caccaccgcc
     9001 agcgcgaccg gcaggttgat ctcctgcttg atccagttga ggatctgggc ggtctggtca
     9061 ttggtccagg cggtatcgac caccagcacg cggccgccat ccctgacgat caaaccgttg
     9121 gaagcgactg ccccgaaacc cggcatgtcg agataggaag tgtgctgcca gacattcggt
     9181 gcgagctggc ggaaaaccag atcgccaaac cgttggtcgc cagtttccat ttgctggcca
     9241 atcgtcgggc ggatttcacc gggcatgcac ccgctcagca tcaatgcagc ggctaatgcg
     9301 gtgctcagct tcgcgaccgg gtgcataata ttgggcaatt ccatcaagtt ttccttttat
     9361 tcagcattaa aaaccccgca aatgcgaggc ctagtaaata gatgatctta atttggttca
     9421 ctgtagcaaa aatatggggc gaattcaaac atgaggtgcg acagtttcaa aagccatatg
     9481 ataatcaaca agctgagcaa atttctctaa tggtgtaagc caatctaacg cctttctagg
     9541 acgagtattc agtgacatgg caacttgatt taaataatgc tgatctgctg gcaatcaggg
     9601 gcatcggtac gactgggcat catctttccc gttcttttat atgcaggaag aacctgcatt
     9661 ctcaagcgca ctcgatgcct tccaaaaagc aggtaatact gtcattggca atgacgtttg
     9721 gatcggctct gaggcaatgg tcatgcccgg aatcaagatc gggcacggtg cggtgatagg
     9781 cagccgctcg ttggtgacaa aagatgtgga gccttacgct atcgttggcg gcaatcccgc
     9841 taagaagatt aagaaacgct tcaccgatga ggaaatttca ttgcttctgg agatggagtg
     9901 gtggaattgg tcactggaga agatcaaagc ggcaatgccc atgctgtgct cgtctaatat
     9961 tgttggcctg cacaagtatt ggctcgagtt tgccgtctaa caattcaatc aagccgatgc
    10021 cgcttcgcgg cacggcttat ttcaggcgtt atgcagccaa atcccaacaa ttaagggtct
    10081 taaaatggta aaagattgga ttcccatctc tcatgataat tacaagcagg tgcaaggacc
    10141 gttctatcat ggaaccaaag ccaatttggc gattggtgac ttgctaacca cagggttcat
    10201 ctctcatttc gaggacggtc gtattcttaa gcacatctac ttttcagcct tgatggagcc
    10261 agcagtttgg ggagctgaac ttgctatgtc actgtctggc ctcgagggtc gcggctacat
    10321 atacatagtt gagccaacag gaccgttcga agacgatccg aatcttacga acaaaagatt
    10381 tcccggtaat ccaacacagt cctatagaac ctgcgaaccc ttgagaattg ttggcgttgt
    10441 tgaagactgg gaggggcatc ctgttgaatt aataagggga atgttggatt cgttggagga
    10501 cttaaagcgc cgtggtttac acgtcattga agactagtcc tttgcataac aaagccatca
    10561 aaccggacgc cagagattcc gcgcctgttg cgcatggctt cgccatttta tgcgcaatag
    10621 gcgcgccacc ctgtcgccgt ttatggcggc gttagatgca ctaagcacat aattgctcac
    10681 agccaaacta tcaggtcaag tctgctttta ttatttttaa gcgtgcataa taagccctac
    10741 acaaattggg agatatatca tgaaaggctg gctttttctt gttatcgcaa tagttggcga
    10801 agtaatcgca acatccgcat taaaatctag cgagggcttt actaagcttg ccccttccgc
    10861 cgttgtcata atcggttatg gcatcgcatt ttattttctt tctctggttc tgaaatccat
    10921 ccctgtcggt gttgcttatg cagtctggtc gggactcggc gtcgtcataa ttacagccat
    10981 tgcctggttg cttcatgggc aaaagcttga tgcgtggggc tttgtaggta tggggctcat
    11041 aattgctgcc tttttgctcg cccgatcccc atcgtggaag tcgctgcgga ggccgacgcc
    11101 atggtgacgg tgttcggcat tctgaatctc accgaggact ccttcttcga tgagagccgg
    11161 cggctagacc ccgccggcgc tgtcaccgcg gcgatcgaaa tgctgcgagt cggatcagac
    11221 gtcgtggatg tcggaccggc cgccagccat ccggacgcga ggcctgtatc gccggccgat
    11281 gagatcagac gtattgcgcc gctcttagac gccctgtccg atcagatgca ccgtgtttca
    11341 atcgacagct tccaaccgga aacccagcgc tatgcgctca agcgcggcgt gggctacctg
    11401 aacgatatcc aaggatttcc tgaccctgcg ctctatcccg atattgctga ggcggactgc
    11461 aggctggtgg ttatgcactc agcgcagcgg gatggcatcg ccacccgcac cggtcacctt
    11521 cgacccgaag acgcgctcga cgagattgtg cggttcttcg aggcgcgggt ttccgccttg
    11581 cgacggagcg gggtcgctgc cgaccggctc atcctcgatc cggggatggg atttttcttg
    11641 agccccgcac cggaaacatc gctgcacgtg ctgtcgaacc ttcaaaagct gaagtcggcg
    11701 ttggggcttc cgctattggt ctcggtgtcg cggaaatcct tcttgggcgc caccgttggc
    11761 cttcctgtaa aggatctggg tccagcgagc cttgcggcgg aacttcacgc gatcggcaat
    11821 ggcgctgact acgtccgcac ccacgcgcct ggagatctgc gaagcgcaat caccttctcg
    11881 gaaaccctcg cgaaatttcg cagtcgcgac gccagagacc gagggttaga tcatgcctag
    11941 cattcacctt ccggccgccc gctagcggac cctggtcagg ttccgcgaag gtgggcgcag
    12001 acatgctggg ctcgtcagga tcaaactgca ctatgaggcg gcggttcata ccgcgccagg
    12061 ggagcgaatg gacagcgagg agcctccgaa cgttcgggtc gcctgctcgg gtgatatcga
    12121 cgaggttgtg cggctgatgc acgacgctgc ggcgtggatg tccgccaagg gaacgcccgc
    12181 ctgggacgtc gcgcggatcg accggacatt cgcggagacc ttcgtcctga gatccgagct
    12241 cctagggatc gcctcagaaa acggaaaata aagcacgcta agccgtaagt aagcgtgctc
    12301 ctgtgaaagc cacagctaaa actgcgtagt acacatagag gtattttttt ctagatttat
    12361 atcgaatttc gttatcgaat ttcgcttatt attgatcaac tcgttgcaga tcatgaaggc
    12421 gaaagtatga cgaataaccc taccgatgac agcagaccat ggtcggtctt tcttattttt
    12481 ctgcggcttg gattgacatc ttttggcggc cccattgcgc acttgggcta cttccgcgcc
    12541 gaatttgtca cacggcggcg ctggctctcc gaacggagct atgctgactt ggtcgcgctt
    12601 tgtcagttct tgccagggcc tgcaagcagc caggtcggca tagcggtagg actgtctcgg
    12661 gctggataca gcggggcgct ggctgcttgg gctggcttca cgctgccgtc tgccatagcc
    12721 ttgatccttt ttgcgctcgg catctccagc tatggcgatt acgtctcgca gggcgcgttg
    12781 catggcttaa aagtggtggc tgtggccgtg gtcgctcaag cagtatgggg catggcgcgt
    12841 aacctatgca cggatgggct gcgagtcacc atcatggcaa ttgctacctg cgtcgtttta
    12901 cttgtgccgt ccgcgtgggg acaggttggc gtgattgcta tcgcaggcat cgcaggccgg
    12961 ttattgttca agccagcgaa agttgttgag catgaccccc tacctatcac ggtcagtcac
    13021 cgggccggcg tgctttggct ctcgctgttc tttgtcttgc tgattggcct gccggtgttg
    13081 gccgaactga tgccaagtca aaccatggca atggtggatt ccttctatcg tgtcggatca
    13141 ctggtgttcg gcggtggtca cgttgtgctg ccattactgc aagccgaagt ggtgccctcc
    13201 ggctgggtca acaatgaatc ctttctcgcg gggtacgggg cagctcaagc ggtgcccggc
    13261 cctttgttca cgttcgccgc gtttcttggt gcctcgatga acaccgcccc gtcgggctgg
    13321 atcggcggca ttgtgtgtct gctggctatc ttcgcgccct cgttcttgct ggtcgtcgga
    13381 tcaatgccat tttgggagcg tttgcgccgc aatacaggca tccaagctgc gctggccggg
    13441 atcaatgccg ctgtagtcgg cttgctgctg gccgcgctgt atcagcctgt atggactagc
    13501 gccatctttc agccgcaaga cttcggcttg gcattagttg cccttgtcgc acttatgttc
    13561 tggaagctcc cgccgtggct ggttgtcctc ggtagcggtg cagctgggtg gctgttgagc
    13621 gtcgctctgt gaggcacaaa aaatgactga caaagacctc tacggcggtt tgatccgcct
    13681 gcacatcctt caccatgcag ccgaggaacc tgtctttggg ctggggatca tcgaagagct
    13741 acgccgacac ggctacgaga tgagcgctgg caccgtgtac ccgatgctgc acggcctgga
    13801 aaaaaaaggc tatctgacct cacgccacga acgcaccggg cgacgtgaac ggcgtgttta
    13861 tgacatcact gaacaaggca gaactgcact tgctgatgcg aaaacaaagg tcaaggagct
    13921 gttcggagag ttggtagaag gtggttgagt ttttgcttct atgtcaggtt gagctatacc
    13981 ctaactggat tgtcattttc agaagacgac tgcac
//
