LOCUS       In1007                 15936 bp    DNA     linear   BCT 29-SEP-2020
DEFINITION  Escherichia coli.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; gamma subdivision; Enterobacteriaceae;
            Escherichia.
REFERENCE   1  (bases 1 to 15936)
  AUTHORS   Zhou,D.
  TITLE     Complete sequence of In1007
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 15936)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2020) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            Beijing, Beijing 100071, China
FEATURES             Location/Qualifiers
     source          1..15936
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:562"
     repeat_region   1..25
                     /gene="IRi_In1007"
     misc_feature    complement(203..1084)
                     /gene="truncated intI1"
                     /product="Truncated Integrase"
     CDS             1246..1845
                     /gene="aacA4cr"
                     /codon_start=1
                     /transl_table=11
                     /product="Fluoroquinolone acetylating
                     aminoglycoside-(6')-N-acetyltransferase AAC(6')-Ib-CR"
                     /translation="MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSH
                     IVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGR
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRA
                     IRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA"
     misc_recomb     1840..1911
                     /gene="attC_aacA4cr"
     CDS             1976..2806
                     /gene="blaOXA-1"
                     /codon_start=1
                     /transl_table=11
                     /product="Class D beta-lactamase OXA-1"
                     /translation="MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCF
                     LLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGM
                     EIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLT
                     EAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGA
                     GFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL
                     "
     misc_recomb     2826..2915
                     /gene="attC_blaOXA-1"
     CDS             2944..3576
                     /gene="catB3"
                     /codon_start=1
                     /transl_table=11
                     /product="Type B-3 chloramphenicol O-acetyltransferase
                     CatB3"
                     /translation="MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCA
                     RYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSAL
                     DAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVEPYAIVGGNPAKK
                     IKKRFTDEEISLLLEMEWWNWSLEKIKAAMPMLCSSNIVGLHKYWLEFAV"
     misc_recomb     3571..3630
                     /gene="attC_catB3"
     CDS             3661..4113
                     /gene="arr3"
                     /codon_start=1
                     /transl_table=11
                     /product="Rifampin ADP-ribosylating transferase"
                     /translation="MVKDWIPISHDNYKQVQGPFYHGTKANLAIGDLLTTGFISHFED
                     GRILKHIYFSALMEPAVWGAELAMSLSGLEGRGYIYIVEPTGPFEDDPNLTNKRFPGN
                     PTQSYRTCEPLRIVGVVEDWEGHPVELIRGMLDSLEDLKRRGLHVIED"
     misc_recomb     4120..4233
                     /gene="attC_arr3"
     misc_feature    4246..4671
                     /gene="truncated dfrA27"
                     /product="Truncated dihydrofolate reductase"
     misc_recomb     4601..4682
                     /gene="attC_truncated dfrA27"
     CDS             4785..5132
                     /gene="qacED1"
                     /codon_start=1
                     /transl_table=11
                     /product="Quarternary ammonium coumpounds resistance
                     protein"
                     /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAF
                     YFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLAR
                     SPSWKSLRRPTPW"
     CDS             5126..5965
                     /gene="sul1"
                     /codon_start=1
                     /transl_table=11
                     /product="Sulfonamide resistance protein"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDV
                     GPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLND
                     IQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSAL
                     RRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGAT
                     VGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGL
                     DHA"
     CDS             6370..7911
                     /gene="tnpA"
                     /codon_start=1
                     /transl_table=11
                     /product="tnpA for ISCR1"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASL
                     EAQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGAR
                     RMAESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIK
                     KAGYTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYD
                     ELNTLAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGP
                     QQGRKVFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPA
                     VSEKRLALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVF
                     APNSKHRVQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVC
                     EHCGGHVKVIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQ
                     SRLFD"
     misc_feature    complement(8089..8424)
                     /gene="truncated bleMBL"
                     /product="Truncated bleomycin resistance protein"
     repeat_region   8123..8143
                     /gene="oriIS"
     CDS             complement(8428..9240)
                     /gene="blaNDM-1"
                     /codon_start=1
                     /transl_table=11
                     /product="Beta-lactamase NDM-1"
                     /translation="MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQ
                     RFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQIL
                     NWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHS
                     LTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSL
                     GNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"
     repeat_region   complement(9334..9359)
                     /gene="IRR_ISAba125"
     misc_feature    complement(9341..9757)
                     /gene="truncated tnpA"
                     /product="Truncated ISAba125 transposase"
     misc_feature    9702..9944
                     /gene="truncated qacED1"
                     /product="Truncated quarternary ammonium coumpounds
                     resistance protein"
     CDS             9938..10777
                     /gene="sul1"
                     /codon_start=1
                     /transl_table=11
                     /product="Sulfonamide resistance protein"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDV
                     GPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLND
                     IQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSAL
                     RRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGAT
                     VGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGL
                     DHA"
     CDS             11182..12723
                     /gene="tnpA"
                     /codon_start=1
                     /transl_table=11
                     /product="tnpA for ISCR1"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASL
                     EAQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGAR
                     RMAESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIK
                     KAGYTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYD
                     ELNTLAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGP
                     QQGRKVFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPA
                     VSEKRLALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVF
                     APNSKHRVQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVC
                     EHCGGHVKVIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQ
                     SRLFD"
     repeat_region   12935..12955
                     /gene="oriIS"
     CDS             13033..13689
                     /gene="qnrA1"
                     /codon_start=1
                     /transl_table=11
                     /product="Quinolone resistance protein"
                     /translation="MDIIDKVFQQEDFSRQDLSDSRFRRCRFYQCDFSHCQLRDASFE
                     DCSFIESGAVEGCHFSYADLRDASFKACRLSLANFSGANCFGIEFRECDLKGANFSRA
                     RFYNQISHKMYFCSAYISGCNLAYANLSGQCLEKCELFENNWSNANLSGASLMGSDLS
                     RGTFSRDCWQQVNLRGCDLTFADLDGLDPRRVNLEGVKICAWQQEQLLEPLGVIVLPD
                     "
     repeat_region   13841..13854
                     /gene="IRL_IS26"
     CDS             13904..14608
                     /gene="tnpA"
                     /codon_start=1
                     /transl_table=11
                     /product="IS26 transposase"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDH
                     STIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTV
                     DFYLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDV
                     EHRQIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYY
                     GDPLGEMRLVSRVFEM"
     repeat_region   14647..14660
                     /gene="IRR_IS26"
     repeat_region   complement(14782..14806)
                     /gene="IRt_In1007"
     repeat_region   14905..14918
                     /gene="IRL_IS6100"
     CDS             14966..15730
                     /gene="tnpA"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6100 transposase"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDH
                     TTIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTID
                     FYLSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETA
                     HRQVKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQ
                     PGIRGEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
     repeat_region   15771..15784
                     /gene="IRR_IS6100"
     repeat_region   15912..15936
                     /gene="IRt_In1007"
ORIGIN      
        1 tgtcgttttc agaagacggc tgcactgaac gtcagaagcc gactgcacta tagcagcgga
       61 ggggttggat ccatcaggca acgacgggct gctgccggcc atcagcggac gcagggagga
      121 ctttccgcaa ccggccgttc gatgcggcac cgatggcctt cgcgcagggg tagtgaatcc
      181 gccaggattg acttgcgctg ccctacctct cactagtgag gggcggcagc gcatcaagcg
      241 gtgagcgcac tccggcaccg ccaactttca gcacatgcgt gtaaatcatc gtcgtagaga
      301 cgtcggaatg gccgagcaga tcctgcacgg ttcgaatgtc gtaaccgctg cggagcaagg
      361 ccgtcgcgaa cgagtggcgg agggtgtgcg gtgtggcggg cttcgtgatg cctgcttgtt
      421 ctacggcacg tttgaaggcg cgctgaaagg tctggtcata catgtgatgg cgacgcacga
      481 caccgctccg tggatcggtc gaatgcgtgt gctgcgcaaa aacccagaac cacggccagg
      541 aatgcccggc gcgcggatac ttccgctcaa gggcgtcggg aagcgcaacg ccgctgcggc
      601 cctcggcctg gtccttcagc caccatgccc gtgcacgcga cagctgctcg cgcaggctgg
      661 gtgccaagct ctcgggtaac atcaaggccc gatccttgga gcccttgccc tcccgcacga
      721 tgatcgtgcc gtgatcgaaa tccagatcct tgacccgcag ttgcaaaccc tcactgatcc
      781 gcatgcccgt tccatacaga agctgggcga acaaacgatg ctcgccttcc agaaaaccga
      841 ggatgcgaac cacttcatcc ggggtcagca ccaccggcaa gcgccgcgac ggccgaggtc
      901 ttccgatctc ctgaagccag ggcagatccg tgcacagcac cttgccgtag aagaacagca
      961 aggccgccaa tgcctgacga tgcgtggaga ccgaaacctt gcgctcgttc gccagccagg
     1021 acagaaatgc ctcgacttcg ctgctgccca aggttgccgg gtgacgcaca ccgtggaaac
     1081 ggatgaaggc acgaacccag tggacataag cctgttcggt tggtaagctg taaagttaga
     1141 tgcactaagc acataattgc tcacagccaa actatcaggt caagtctgct tttattattt
     1201 ttaagcgtgc ataataagcc ctacacaaat tgggagttag acatcatgag caacgcaaaa
     1261 acaaagttag gcatcacaaa gtacagcatc gtgaccaaca gcaacgattc cgtcacactg
     1321 cgcctcatga ctgagcatga ccttgcgatg ctctatgagt ggctaaatcg atctcatatc
     1381 gtcgagtggt ggggcggaga agaagcacgc ccgacacttg ctgacgtaca ggaacagtac
     1441 ttgccaagcg ttttagcgca agagtccgtc actccataca ttgcaatgct gaatggagag
     1501 ccgattgggt atgcccagtc gtacgttgct cttggaagcg gggacggaag gtgggaagaa
     1561 gaaaccgatc caggagtacg cggaatagac cagttactgg cgaatgcatc acaactgggc
     1621 aaaggcttgg gaaccaagct ggttcgagct ctggttgagt tgctgttcaa tgatcccgag
     1681 gtcaccaaga tccaaacgga cccgtcgccg agcaacttgc gagcgatccg atgctacgag
     1741 aaagcggggt ttgagaggca aggtaccgta accaccccat atggtccagc cgtgtacatg
     1801 gttcaaacac gccaggcatt cgagcgaaca cgcagtgatg cctaaccctt ccatcgaggg
     1861 ggacgtccaa gggctggcgc ccttggccgc ccctcatgtc aaacgttggg cgaacccgga
     1921 gcctcattaa ttgttagccg ttaaaattaa gccctttacc aaaccaatac ttattatgaa
     1981 aaacacaata catatcaact tcgctatttt tttaataatt gcaaatatta tctacagcag
     2041 cgccagtgca tcaacagata tctctactgt tgcatctcca ttatttgaag gaactgaagg
     2101 ttgtttttta ctttacgatg catccacaaa cgctgaaatt gctcaattca ataaagcaaa
     2161 gtgtgcaacg caaatggcac cagattcaac tttcaagatc gcattatcac ttatggcatt
     2221 tgatgcggaa ataatagatc agaaaaccat attcaaatgg gataaaaccc ccaaaggaat
     2281 ggagatctgg aacagcaatc atacaccaaa gacgtggatg caattttctg ttgtttgggt
     2341 ttcgcaagaa ataacccaaa aaattggatt aaataaaatc aagaattatc tcaaagattt
     2401 tgattatgga aatcaagact tctctggaga taaagaaaga aacaacggat taacagaagc
     2461 atggctcgaa agtagcttaa aaatttcacc agaagaacaa attcaattcc tgcgtaaaat
     2521 tattaatcac aatctcccag ttaaaaactc agccatagaa aacaccatag agaacatgta
     2581 tctacaagat ctggataata gtacaaaact gtatgggaaa actggtgcag gattcacagc
     2641 aaatagaacc ttacaaaacg gatggtttga agggtttatt ataagcaaat caggacataa
     2701 atatgttttt gtgtccgcac ttacaggaaa cttggggtcg aatttaacat caagcataaa
     2761 agccaagaaa aatgcgatca ccattctaaa cacactaaat ttataaaaaa tctaatggca
     2821 aaatcgccca acccttcaat caagtcggga cggccaaaag caagcttttg gctcccctcg
     2881 ctggcgctcg gcgcccctta tttcaaacgt tagacggcaa agtcacagac cgcgggatct
     2941 cttatgacca actactttga tagccccttc aaaggcaagc tgctttctga gcaagtgaag
     3001 aaccccaata tcaaagttgg gcggtacagc tattactctg gctactatca tgggcactca
     3061 ttcgatgact gcgcacggta tctgtttccg gaccgtgatg acgttgataa gttgatcatc
     3121 ggtagtttct gctctatcgg gagtggggct tcctttatca tggctggcaa tcaggggcat
     3181 cggtacgact gggcatcatc tttcccgttc ttttatatgc aggaagaacc tgcattctca
     3241 agcgcactcg atgccttcca aaaagcaggt aatactgtca ttggcaatga cgtttggatc
     3301 ggctctgagg caatggtcat gcccggaatc aagatcgggc acggtgcggt gataggcagc
     3361 cgctcgttgg tgacaaaaga tgtggagcct tacgctatcg ttggcggcaa tcccgctaag
     3421 aagattaaga aacgcttcac cgatgaggaa atttcattgc ttctggagat ggagtggtgg
     3481 aattggtcac tggagaagat caaagcggca atgcccatgc tgtgctcgtc taatattgtt
     3541 ggcctgcaca agtattggct cgagtttgcc gtctaacaat tcaatcaagc cgatgccgct
     3601 tcgcggcacg gcttatttca ggcgttatgc agccaaatcc caacaattaa gggtcttaaa
     3661 atggtaaaag attggattcc catctctcat gataattaca agcaggtgca aggaccgttc
     3721 tatcatggaa ccaaagccaa tttggcgatt ggtgacttgc taaccacagg gttcatctct
     3781 catttcgagg acggtcgtat tcttaagcac atctactttt cagccttgat ggagccagca
     3841 gtttggggag ctgaacttgc tatgtcactg tctggcctcg agggtcgcgg ctacatatac
     3901 atagttgagc caacaggacc gttcgaagac gatccgaatc ttacgaacaa aagatttccc
     3961 ggtaatccaa cacagtccta tagaacctgc gaacccttga gaattgttgg cgttgttgaa
     4021 gactgggagg ggcatcctgt tgaattaata aggggaatgt tggattcgtt ggaggactta
     4081 aagcgccgtg gtttacacgt cattgaagac tagtcctttg cataacaaag ccatcaaacc
     4141 ggacgccaga gattccgcgc ctgttgcgca tggcttcgcc attttatgcg caataggcgc
     4201 gccaccctgt cgccgtttat ggcggcgtta acccaaagga gtatcgtgaa aatatcacta
     4261 atggctgcaa aagcaagaaa tggggttatt ggctgcggct cggatatccc gtggaacgct
     4321 aaaggtgagc agctgctttt taaagcaata acttacaatc aatggctctt agtcggccgt
     4381 aaaacatttg aggcaatggg ggctctccca aatagaaagt atgcagttgt cagccgctca
     4441 ggatcggtag ctactaacga tgatgtggtt gtgtttccat ctatagaagc agcaatgagg
     4501 gagcaatgtt ttctttccgg aaatccccaa agagttcaat gtggtgttcg agcaggaatt
     4561 tcattcaaat ataaattatc gctatcaaat ctggcaaagg ggttaaccat ccaagccatc
     4621 ggacacattt tgcttcgctg cgctcaaaac gcaaaatgtg ccgctgctta gcggcgttag
     4681 atgcactaag cacataattg ctcacagcca aactatcagg tcaagtctgc ttttattatt
     4741 tttaagcgtg cataataagc cctacacaaa ttgggagata tatcatgaaa ggctggcttt
     4801 ttcttgttat cgcaatagtt ggcgaagtaa tcgcaacatc cgcattaaaa tctagcgagg
     4861 gctttactaa gcttgcccct tccgccgttg tcataatcgg ttatggcatc gcattttatt
     4921 ttctttctct ggttctgaaa tccatccctg tcggtgttgc ttatgcagtc tggtcgggac
     4981 tcggcgtcgt cataattaca gccattgcct ggttgcttca tgggcaaaag cttgatgcgt
     5041 ggggctttgt aggtatgggg ctcataattg ctgccttttt gctcgcccga tccccatcgt
     5101 ggaagtcgct gcggaggccg acgccatggt gacggtgttc ggcattctga atctcaccga
     5161 ggactccttc ttcgatgaga gccggcggct agaccccgcc ggcgctgtca ccgcggcgat
     5221 cgaaatgctg cgagtcggat cagacgtcgt ggatgtcgga ccggccgcca gccatccgga
     5281 cgcgaggcct gtatcgccgg ccgatgagat cagacgtatt gcgccgctct tagacgccct
     5341 gtccgatcag atgcaccgtg tttcaatcga cagcttccaa ccggaaaccc agcgctatgc
     5401 gctcaagcgc ggcgtgggct acctgaacga tatccaagga tttcctgacc ctgcgctcta
     5461 tcccgatatt gctgaggcgg actgcaggct ggtggttatg cactcagcgc agcgggatgg
     5521 catcgccacc cgcaccggtc accttcgacc cgaagacgcg ctcgacgaga ttgtgcggtt
     5581 cttcgaggcg cgggtttccg ccttgcgacg gagcggggtc gctgccgacc ggctcatcct
     5641 cgatccgggg atgggatttt tcttgagccc cgcaccggaa acatcgctgc acgtgctgtc
     5701 gaaccttcaa aagctgaagt cggcgttggg gcttccgcta ttggtctcgg tgtcgcggaa
     5761 atccttcttg ggcgccaccg ttggccttcc tgtaaaggat ctgggtccag cgagccttgc
     5821 ggcggaactt cacgcgatcg gcaatggcgc tgactacgtc cgcacccacg cgcctggaga
     5881 tctgcgaagc gcaatcacct tctcggaaac cctcgcgaaa tttcgcagtc gcgacgccag
     5941 agaccgaggg ttagatcatg cctagcattc accttccggc cgcccgctaa atatctcctt
     6001 ttgggttgtt aataaaacat ccaataagtt gactgtgcgt gaaaaagaaa gttttgtgtg
     6061 atggcgttga agatcgcacc gttaagctct tatgtgggat ggtgcagagc tcgacgacta
     6121 ccgataaaac gcaaccgccg caaacagaca agaaaaagcc ccaactgata acagttgggg
     6181 cttcagtatt gtgattggtg gagcaatagc accctgaacc caaaaccttc tcgctcaacc
     6241 ggtagtggct gataacaact cgtgagggct attgcgggtt aagcatttag cgatgtctag
     6301 ggccagactg gacgtctgaa cgcaagccgc tgatactgta cataaccaca gtatcagcgg
     6361 aggataccca tgtcgctggc aaggaacgcc acggcgagtc aatcgcccac tcaaacaaac
     6421 ggttacgaac gccaccaacc cgaccagacg ctgctctacc agctggttga gcagcactac
     6481 ccagccttca aagcctcact cgaagcccaa ggtcaacacc tgcctcgcta catccaacaa
     6541 gaattcaacg acctcctcca atgtggccgt ctggagtatg gtttcatgcg ggttcgctgc
     6601 gaggattgtc atcacgagcg tctggtcgcc ttcagctgta aacgacgcgg cttttgccct
     6661 agctgcggtg cccgccggat ggccgagagt gcggcgctgc tgatagacga agtcttcccc
     6721 aaggagccca ttcgccagtg ggtgctcagc tttcctttcc agctacgctt tttgctggct
     6781 cgccatcccc agctgatggg ccaggtcttg agtatcgtct atcgtacact ctcaactcat
     6841 ctgatcaaaa aagccggtta caccaaagcc tctgcacaaa ctggctcagt gactcttatc
     6901 caacgctttg gctccgcgct aaatctcaat gtccactacc acatgctgtt tctcgatggt
     6961 gtctatgccg aagatgacta tggcaagcaa cgcttccatc gtgtcaaggc acccacttac
     7021 gatgagctga atacgctcgc tcacaccctc agccatcgca tcgctcgctg catggaaaag
     7081 cgtgggattt tggagcgtga tgccgagaat acgtggttga cactggaaga gggcgaagac
     7141 gatacgctga ctcaattaca tggtgcttcg gttacgtatc gcattgccgt cggcccccag
     7201 caagggcgca aagtcttcac cctgcaaacc ttgccagggc gtgaggataa agccgactca
     7261 agcagtcgag tagccaacca tgctggtttc tcgctacacg ccggtgtgat ggccgaagcg
     7321 catcagcggg ataagcttga gcgcttgtgt cgctacatta gtcggccagc ggtttcagaa
     7381 aaacgtctgg cattaaccgc caatgggcag gtgcgttacg agctcaaaac tccgtaccgc
     7441 aatggcacca cccatgtgat cttcgagccg ctggacttca tcgccaaact cgctgcgttg
     7501 gtacctaagc cgcgagtcaa cctcacacgc ttccacggcg tctttgcacc gaacagcaaa
     7561 caccgagttc aagtaacacc cgccaagcgg ggcaagaagc ccgacaaatc ggaaggtctc
     7621 gatactaact ggcgtgacaa gagtcctgca gagcgccacc gcgccatgac ctggatgcaa
     7681 cgcctcaagc gagtcttcaa tattgatatt gaagtctgcg aacactgcgg cggtcacgtc
     7741 aaagtgattg ccagcatcga agatccgaag gtcattgagc agattctcaa gcatctgaaa
     7801 cagaaaacag ccaaggcgaa tgccgccaag cagcgtgagc tgccaccaga acgagcgccg
     7861 ccactgactc ccagcctgtt cgatccatca cagagtcgtc tctttgactg acgaccccaa
     7921 atccaacact gctcaacact gccaactttt aaacggggcg gtggggcagt ttgtatctct
     7981 cgagctatca ggctagagat tttaccgcca aatcgaacct tattagagcg gtttaggctg
     8041 gaccggcagt taaaattggg gcttgagcgg taaacgagtg agggaatttc aggtaagata
     8101 cttcggatga ggagcaaaaa ggtggtttat acttcctata cccggagctt tgaagcgcgg
     8161 ccagccggtg cttttttcct cggctcccgc cgcgttcacc aatgccacca tggcatcgag
     8221 atcatccaac cgcaggcaac agccgaacga gctcgtagct gggtcgaggt caggataggg
     8281 gaagaattcg agctgcaaac cgccgcgctg caggatcatc cagccgcgat ccttccaact
     8341 cgtcgcaaag cccagcttcg cataaaacgc ctctgtcaca tcgaaatcgc gcgatggcag
     8401 attgggggtg acgtggtcag ccatggctca gcgcagcttg tcggccatgc gggccgtatg
     8461 agtgattgcg gcgcggctat cgggggcgga atggctcatc acgatcatgc tggccttggg
     8521 gaacgccgca ccaaacgcgc gcgctgacgc ggcgtagtgc tcagtgtcgg catcaccgag
     8581 attgccgagc gacttggcct tgctgtcctt gatcaggcag ccaccaaaag cgatgtcggt
     8641 gccgtcgatc ccaacggtga tattgtcact ggtgtggccg gggccggggt aaaatacctt
     8701 gagcgggcca aagttgggcg cggttgctgg ttcgacccag ccattggcgg cgaaagtcag
     8761 gctgtgttgc gccgcaacca tcccctcttg cggggcaagc tggttcgaca acgcattggc
     8821 ataagtcgca atccccgccg catgcagcgc gtccataccg cccatcttgt cctgatgcgc
     8881 gtgagtcacc accgccagcg cgaccggcag gttgatctcc tgcttgatcc agttgaggat
     8941 ctgggcggtc tggtcatcgg tccaggcggt atcgaccacc agcacgcggc cgccatccct
     9001 gacgatcaaa ccgttggaag cgactgcccc gaaacccggc atgtcgagat aggaagtgtg
     9061 ctgccagaca ttcggtgcga gctggcggaa aaccagatcg ccaaaccgtt ggtcgccagt
     9121 ttccatttgc tggccaatcg tcgggcggat ttcaccgggc atgcacccgc tcagcatcaa
     9181 tgcagcggct aatgcggtgc tcagcttcgc gaccgggtgc ataatattgg gcaattccat
     9241 caagttttcc ttttattcag cattaaaaac cccgcaaatg cgaggcctag taaatagatg
     9301 atcttaattt ggttcactgt agcaaaaata tggggcgaat tcaaacatga ggtgcgacag
     9361 tttcaaaagc catatgataa tcaacaagct gagcaaattt ctctaatggt gtaagccaat
     9421 ctaacgcctt tctaggacga gtattcagtg acatggcaac ttgatttaaa taatgctgat
     9481 ctgcctgatt taaatcaatc cctttaggta aatattgcct aattaaacca ttcatatttt
     9541 cgcatgtgcc tttttgccag ggtgaatgtg ggtcacagaa atatacatct atgcctaaat
     9601 cttcttcgag tattttatgt tctgacatct cacgtccacg gtcataggtc aacgttttac
     9661 gcagttctgc aggtaaatat ttcagagctt cagttaaagc cttgcgcact gattctgcct
     9721 ttgcatcagg taatgttgct ctggttctga aatccatccc tgtcggtgtt gcttatgcag
     9781 tctggtcggg actcggcgtc gtcataatta cagccattgc ctggttgctt catgggcaaa
     9841 agcttgatgc gtggggcttt gtaggtatgg ggctcataat tgctgccttt ttgctcgccc
     9901 gatccccatc gtggaagtcg ctgcggaggc cgacgccatg gtgacggtgt tcggcattct
     9961 gaatctcacc gaggactcct tcttcgatga gagccggcgg ctagaccccg ccggcgctgt
    10021 caccgcggcg atcgaaatgc tgcgagtcgg atcagacgtc gtggatgtcg gaccggccgc
    10081 cagccatccg gacgcgaggc ctgtatcgcc ggccgatgag atcagacgta ttgcgccgct
    10141 cttagacgcc ctgtccgatc agatgcaccg tgtttcaatc gacagcttcc aaccggaaac
    10201 ccagcgctat gcgctcaagc gcggcgtggg ctacctgaac gatatccaag gatttcctga
    10261 ccctgcgctc tatcccgata ttgctgaggc ggactgcagg ctggtggtta tgcactcagc
    10321 gcagcgggat ggcatcgcca cccgcaccgg tcaccttcga cccgaagacg cgctcgacga
    10381 gattgtgcgg ttcttcgagg cgcgggtttc cgccttgcga cggagcgggg tcgctgccga
    10441 ccggctcatc ctcgatccgg ggatgggatt tttcttgagc cccgcaccgg aaacatcgct
    10501 gcacgtgctg tcgaaccttc aaaagctgaa gtcggcgttg gggcttccgc tattggtctc
    10561 ggtgtcgcgg aaatccttct tgggcgccac cgttggcctt cctgtaaagg atctgggtcc
    10621 agcgagcctt gcggcggaac ttcacgcgat cggcaatggc gctgactacg tccgcaccca
    10681 cgcgcctgga gatctgcgaa gcgcaatcac cttctcggaa accctcgcga aatttcgcag
    10741 tcgcgacgcc agagaccgag ggttagatca tgcctagcat tcaccttccg gccgcccgct
    10801 aaatatctcc ttttgggttg ttaataaaac atccaataag ttgactgtgc gtgaaaaaga
    10861 aagttttgtg tgatggcgtt gaagatcgca ccgttaagct cttatgtggg atggtgcaga
    10921 gctcgacgac taccgataaa acgcaaccgc cgcaaacaga caagaaaaag ccccaactga
    10981 taacagttgg ggcttcagta ttgtgattgg tggagcaata gcaccctgaa cccaaaacct
    11041 tctcgctcaa ccggtagtgg ctgataacaa ctcgtgaggg ctattgcggg ttaagcattt
    11101 agcgatgtct agggccagac tggacgtctg aacgcaagcc gctgatactg tacataacca
    11161 cagtatcagc ggaggatacc catgtcgctg gcaaggaacg ccacggcgag tcaatcgccc
    11221 actcaaacaa acggttacga acgccaccaa cccgaccaga cgctgctcta ccagctggtt
    11281 gagcagcact acccagcctt caaagcctca ctcgaagccc aaggtcaaca cctgcctcgc
    11341 tacatccaac aagaattcaa cgacctcctc caatgtggcc gtctggagta tggtttcatg
    11401 cgggttcgct gcgaggattg tcatcacgag cgtctggtcg ccttcagctg taaacgacgc
    11461 ggcttttgcc ctagctgcgg tgcccgccgg atggccgaga gtgcggcgct gctgatagac
    11521 gaagtcttcc ccaaggagcc cattcgccag tgggtgctca gctttccttt ccagctacgc
    11581 tttttgctgg ctcgccatcc ccagctgatg ggccaggtct tgagtatcgt ctatcgtaca
    11641 ctctcaactc atctgatcaa aaaagccggt tacaccaaag cctctgcaca aactggctca
    11701 gtgactctta tccaacgctt tggctccgcg ctaaatctca atgtccacta ccacatgctg
    11761 tttctcgatg gtgtctatgc cgaagatgac tatggcaagc aacgcttcca tcgtgtcaag
    11821 gcacccactt acgatgagct gaatacgctc gctcacaccc tcagccatcg catcgctcgc
    11881 tgcatggaaa agcgtgggat tttggagcgt gatgccgaga atacgtggtt gacactggaa
    11941 gagggcgaag acgatacgct gactcaatta catggtgctt cggttacgta tcgcattgcc
    12001 gtcggccccc agcaagggcg caaagtcttc accctgcaaa ccttgccagg gcgtgaggat
    12061 aaagccgact caagcagtcg agtagccaac catgctggtt tctcgctaca cgccggtgtg
    12121 atggccgaag cgcatcagcg ggataagctt gagcgcttgt gtcgctacat tagtcggcca
    12181 gcggtttcag aaaaacgtct ggcattaacc gccaatgggc aggtgcgtta cgagctcaaa
    12241 actccgtacc gcaatggcac cacccatgtg atcttcgagc cgctggactt catcgccaaa
    12301 ctcgctgcgt tggtacctaa gccgcgagtc aacctcacac gcttccacgg cgtctttgca
    12361 ccgaacagca aacaccgagt tcaagtaaca cccgccaagc ggggcaagaa gcccgacaaa
    12421 tcggaaggtc tcgatactaa ctggcgtgac aagagtcctg cagagcgcca ccgcgccatg
    12481 acctggatgc aacgcctcaa gcgagtcttc aatattgata ttgaagtctg cgaacactgc
    12541 ggcggtcacg tcaaagtgat tgccagcatc gaagatccga aggtcattga gcagattctc
    12601 aagcatctga aacagaaaac agccaaggcg aatgccgcca agcagcgtga gctgccacca
    12661 gaacgagcgc cgccactgac tcccagcctg ttcgatccat cacagagtcg tctctttgac
    12721 tgacgacccc aaatccaaca ctgctcaaca ctgccaactt ttaaacgggg cggtggggca
    12781 gtttgtatct ctcgagctat caggctagag attttaccgc caaatcgaac cttattagag
    12841 cggtttaggc tggaccggca gttaaaattg gggcttgagc ggtaaacgag tgagggaatt
    12901 tcaggtaaga tacttcggat gaggagcaaa aaggtggttt atacttccta tacccccaac
    12961 aaaccccatg cttgcctgca taggcagagc tagcaaagag agttagcgcc ctccctggtt
    13021 aaaggaagcc gtatggatat tattgataaa gtttttcagc aagaggattt ctcacgccag
    13081 gatttgagcg acagccgttt tcgccgctgc cgcttttatc agtgtgactt cagccattgc
    13141 cagctaaggg atgccagttt cgaggattgc agtttcattg aaagcggcgc cgtcgaaggg
    13201 tgccacttca gctatgccga tctgcgcgat gccagtttca aggcctgccg cctgtctttg
    13261 gccaatttca gcggtgccaa ctgctttggc atagagttca gggagtgcga tctcaagggt
    13321 gccaattttt cccgggcccg tttttacaat caaatcagcc ataagatgta cttctgctcg
    13381 gcttatatct caggctgcaa cctggcctat gccaatttga gcggccaatg cctggaaaag
    13441 tgcgagctgt ttgaaaacaa ctggagcaat gccaacctca gcggcgcttc cttgatgggc
    13501 tccgacctca gccgcggcac cttctcccgc gactgctggc aacaggtaaa cctgcggggc
    13561 tgtgacctga cctttgccga tctggatggg ctcgacccca gacgggtcaa cctcgaaggg
    13621 gtcaagatct gtgcctggca gcaggagcaa ctgctggaac ccttgggagt catagtgctg
    13681 ccggattagt tcaaaggcag actcaagcga caagcgggca aatatcactt gagttcccgc
    13741 ttgcaacagg gcagattcag ctatagcaga gcataaccgc cgaaatgccg ttttctctgc
    13801 tgtcgcagcc ggcgttatac cttcccttaa aaggaggcat ggcactgttg caaatagtcg
    13861 gtggtgataa acttatcatc cccttttgct gatggagctg cacatgaacc cattcaaagg
    13921 ccggcatttt cagcgtgaca tcattctgtg ggccgtacgc tggtactgca aatacggcat
    13981 cagttaccgt gagctgcagg agatgctggc tgaacgcgga gtgaatgtcg atcactccac
    14041 gatttaccgc tgggttcagc gttatgcgcc tgaaatggaa aaacggctgc gctggtactg
    14101 gcgtaaccct tccgatcttt gcccgtggca catggatgaa acctacgtga aggtcaatgg
    14161 ccgctgggcg tatctgtacc gggccgtcga cagccggggc cgcactgtcg atttttatct
    14221 ctcctcccgt cgtaacagca aagctgcata ccggtttctg ggtaaaatcc tcaacaacgt
    14281 gaagaagtgg cagatcccgc gattcatcaa cacggataaa gcgcccgcct atggtcgcgc
    14341 gcttgctctg ctcaaacgcg aaggccggtg cccgtctgac gttgaacacc gacagattaa
    14401 gtaccggaac aacgtgattg aatgcgatca tggcaaactg aaacggataa tcggcgccac
    14461 gctgggattt aaatccatga agacggctta cgccaccatc aaaggtattg aggtgatgcg
    14521 tgcactacgc aaaggccagg cctcagcatt ttattatggt gatcccctgg gcgaaatgcg
    14581 cctggtaagc agagtttttg aaatgtaagg cctttgaata agacaaaagg ctgcctcatc
    14641 gctaactttg caacagtgcc cttcagcctg cctgggcgag atctccggcg gacggattaa
    14701 cggcggagct tcgccgcctt tcgtgcgtgt gaaggccgaa gatagttctc tcaaaaacat
    14761 ccgtttatga gagataccaa atgtcatttt cagaagacga ctgcaccagt tgattgggcg
    14821 taatggctgt tgtgcagcca gctcctgaca gttcaatatc agaagtgatc tgcaccaatc
    14881 tcgactatgc tcaatactcg tgtgggctct gttgcaaaaa tcgtgaagct tgagcatgct
    14941 tggcggagat tggacggacg gaacgatgac ggatttcaag tggcgccatt tccagggtga
    15001 tgtgatcctg tgggcggtgc gctggtattg tcgctatccg atcagctatc gcgaccttga
    15061 ggaaatgctg gcggaacgcg gcatttcggt cgaccatacg acgatctatc gctgggtcca
    15121 gtgctacgcc ccggagatgg agaagcggct gcgctggttc tggcggcgtg gctttgatcc
    15181 gagctggcgc ctggatgaaa cctacgtcaa ggtgcggggc aagtggacct acctgtaccg
    15241 ggcagtcgac aagcggggcg acacgatcga tttctacctg tcgccgaccc gcagcgccaa
    15301 ggcagcgaag cggttcctgg gcaaggccct gcgaggcctg aagcactggg aaaagcctgc
    15361 cacgctcaat accgacaaag cgccgagcta tggtgcagcg atcaccgaat tgaagcgcga
    15421 aggaaagctg gaccgggaga cggcccaccg gcaggtgaag tatctcaata acgtgatcga
    15481 ggccgatcac ggaaagctca agatactgat caagccggtg cgcggtttca aatcgatccc
    15541 cacggcctat gccacgatca agggattcga agtcatgcga gccctgcgca aaggacaggc
    15601 tcgcccctgg tgcctgcagc ccggcatcag gggcgaggtg cgccttgtgg agagagcttt
    15661 tggcattggg ccctcggcgc tgacggaggc catgggcatg ctcaaccacc atttcgcagc
    15721 agccgcctga tcggcgcaga gcgacagcct acctctgact gccgccaatc tttgcaacag
    15781 agcctccgtc gccatgctca cctcgctttg gtgcacacga gtattgagca tagtcgagat
    15841 tggtgcagat cacttctgat attgaactgt caggagctgg ctgcacaaca gccattacgc
    15901 ccaatcaact ggtgcagtcg tcttctgaaa atgaca
//
